The Argentine Study Continues

January 20, 2010 – 1:16 pm

Mt. Aconcagua - study site, alt. 22,000 ft.

Benegas and Luke wait out the wind

Jacob, Robert Fry, Diane Van Deren, Luke Johnson

Update 2-5-10 — 4 p.m. Received this message from Dr. Bruce  Johnson:

At  18,000 ft the cold and winds picked up causing us to retreat back to base camp (14,000).

We are focusing on monitoring Diane and Willie Benegas (the elite climber-guide going with Diane-also North Face athlete) and working through our equipment.  It is not easy doing science without a laboratory, when temps are below zero, winds are high…   The goal with the first ascent is really to acclimatize everyone, particularly Diane for the speed ascent which is suppose to be on the 12th.  

For this we will set them up (Diane and Willie) with 3 devices, a nonin wrist ox, a body media device and a Hildago system.  We will also use the New Leaf system.  In all we will measure heart rate, respiration rate, core temperature, skin temperature, metabolic rate, oxygen saturation and gas exchange (oxygen consumption, carbon dioxide production, ventilation and end tidal CO2 and O2).  

We will instrument them on the 12th. The speed ascent will start around 4 p.m. and then they will go continuously up to the summit and down the other side of the mountain.

Luke will do some baseline measures with New Leaf and then ride a mule up to base camp to make some measures there and Paul will do a quick ascent around the other side of the mountain to capture measures at camp 2 and to check devices and may follow to the summit.  We will also have an altimeter and GPS to go with our system.

I am not sure our goal as a Mayo team is to get to the summit, it is really to do good science.

In the end we will have some great data on the folks from North Face and the newspaper executive from Argentina – Hector D’Amico – Editor and Chief of La Nacion.  A great man also writing about us.

All is well, testing is good. Most will try for another ascent on Monday.  – Bruce

Update 2-5/10 – 11 a.m. Received this message today from Diane Van Deren:

At base camp keep prayers for all this mt is massive  love you docs are working super hard di

Update: 2-4-10 — Waiting for word on location of the team. They appear to be near the top judging from the photos we’ve just received.

View from near 20,000 feet

High Altitude Camp, waiting out the winds

Diane Van Deren (R) and Dr. Bruce Johnson

Personal updates from Base Camp — (Willie and Kasha are other climbers who are involved with the project):

Update 1-30-10: Message from Diane:

Wow what a day! I was going to try and call but it’s either a phone call or a shower! Sorry, this girl needs a shower before we head up the mountain. So, what a day today I have to share with you. Mayo Clinic here and Willie going over our different training we need to be doing for speed attempt. Willie took me to 18000 ft today…all my oxygen saturation levels and heart rate etc are perfect today! Was really special because Mayo went over emergency meds I have etc. with Willie and how my wirng system is showing all signs. It really was so great to feel awesome climbing to 18000 feet! Willie knows people on the mt. and we did see some high altitude sickness. Med teams came for them quickly. When Willie and I got to 18000 feet at Camp Nido we had lunch with the med staff there and they will assist us on mt if emergency is needed for Willie and me. So great to meet the staff. It was stunning to be on top of the mt on a crystal clear blue sky day and you could see forever! I told Bruce and Luke that I think this is a glance of what heaven is going to be like. It was great to climb and feel in my element. No headache, no tightness of lungs etc. As we know there can be lows also but when it all comes together its wonderful! Tomorrow we will take gear to camp one and we will not have contact for maybe 6 7 8 days as it depends on weather conditions on the mt. No summitting today because of the winds. Well love to everyone and keep prayers for everyone…start the summit tomorrow xo Di

Update from Kasha Rigby – “As we bathe in the alpenglow of this evening we forget the storms of the last few nights. we are all at plaza de mulas, our basecamp, and feeling well. the weather has been predictably unstable – sunny and clear in the mornings but by mid day clouds building with electricity and rain. we had one clear night where we were able to identify the southern cross and watch a magical moonrise, but the last couple nights have been rain down lower and snow higher, mixed with gropple and hail. the infamous andean winds have luckily not hit us yet.

willie arrived this morning after running in from the highway in 3 hours – a journey that took us two days. we were starting to worry he might have to winter over in antarctica. he arrived feeling fresh, before those of us languishing on a rest day had even begun breakfast. he brings the news that weather should improve for at least the next 4 days giving us time to establish ourselves higher on the mountain.
in the meantime we eat and drink and rest. acclimitization and hydration are such critical pieces for success higher on the mountain. monitored by our mayo clinic doctors we have all become compulsively interested in our heart rates and blood/oxygen saturation. today we all weighed in and each have lost between 2-5 pounds and we have not even really started the climb. we have been going through a series of resting and step tests to see how our bodies react and recover

we are a formidable group – 22 now with willie, but moving together with an amazing efficiency that can only be attained with each member being highly conscious of working as a group. it is impressive to be with such skilled and professional individuals, each adding their unique perspective and experience.

tomorrow we take a load to camp one, a steep scree climb, and then come back to basecamp for one more night.
being here with diane and her team of mayo doctors/scientists is such a great honor. watching diane pace herself and the focus of the team is a treat and an inspiration!

Update 1-31-10: From Willie Benegas

we brought a load of hard gear, food and some tents to camp one yesterday, just over 16,000 feet. our group of 22 represents el salvador, argentina, chile, the us, uk, and venezuela so at this point many of the group are at a new high point with each step – for many their first real climb of a mountain. it brings a sweet freshness to our climb.

we have moved into a high pressure weather system with the full moon but with this comes evidence of winds up high. last night we were treated to a ridiculous sunset and then full moon rise over the ridge of aconcagua.

diane and willlie strike out ahead of the group each day and were headed out again early this morning while the rest of us sorted gear and rested at camp. on their accelerated acclimitazation program they went to over 18,000 ft today. kasha has held full yoga classes each afternoon with the the peak on one side and the crashing of seracs on the other – breathtaking surroundings in which to practice. damian is madly keeping things organized and flowing smoothly for our giant group with such mixed experience and objectives, we will run through another set of tests with the mayo doctors this afternoon.

and tomorrow we head up the mountain. our plan will be to set three camps on the mountain over 4 days and then head for the summit. with good luck and weather we hope to summit on on the 5th and be back in basecamp maybe that night or the next day. no dispatches while we are on the mountain but we will take heaps of pictures to share.

we are headed out! the winds of yesterday turned most people off the summit but look like they have settled down a wee bit. wish us luck!

More photos:

Base Camp

Uphill from here on out

Starting out -the first ascent

Update: 1/31/10 – The latest is that the initial climb has been successful thus far – but high winds have become an issue. Over the next six days they hope to complete the ascent. Diane notifies us via Twitter that her “numbers” are right where they should be. Team members are now going over equipment and reading for a second speed ascent, but that won’t happen for a while – until the first ascent is complete and participants rest. Dr. Bruce Johnson tells us some winds are approaching 90 mph.  Everyone doing well and in good spirits.

Update: 1/29/10 – More images from Argentina:

Luke and Hector discuss the ascent

The Mayo Research Team

Dr. Paul Anderson explains equipment to climbers

Update 1/28/10 – The team is making good progress, part way up the mountain. Below is an excerpt from a message from Dr. Bruce Johnson:

Limited (email) access here at base camp.  All is well, still strategizing with Damian, Willie, Diane and us.  Altitude is 4000-4500 meters.  Our team is many of The North Face South American Leadership, guides, porters, mules.  A rest day today, but about a 1000 m climb tomorrow. no more mules. We spend our time now acclimating and pushing gear up higher and higher to camp 1, 2, 3.  We have lots of footage, interview, etc.  We also have with us a high ranking executive of the largest newspaper in Argentina, La Nacion.  He did an interview with us today.  They all love Mayo Clinic!  There is much to learn in field studies, but so far so good.  Diane is doing extra training each day.  This has been a bad year for cerebral edema on the mountain, but not sure why at this point.  Possibly related to large changes in pressure.  Most of us have lost 3-5 lbs.

Dr. Bruce Johnson testing Diane at base camp prior to 1st ascent

the team heads for the mountain

Update 1/25/10 - The team has begun its trek up the mountain after doing some basic physiology tests with Diane at the base lodge. The team was without e-mail access for about a day and a half – details and photos are beginning to come in and we will share here through the day. All going well.

Update 1/23/10: A message from Dana Sparks, from Mayo Clinic Public Affairs, who is facilitating the film crew and communications from the scene:

Sun is shining and cooler temps this morning. Last night was a team dinner with over 20 climbers from all over the world! Diane said North Face has identified some of them to be stationed at different points on the mountain for safety, when she and Willie do the speed ascent. Everybody is loading gear into trucks right now for the trip to Penitentes where Dr. Johnson will do his orientation describing the research equipment and the teams plan to monitor Diane on the climbs. Our camera crew has more gear than the 3 climbers combined! We’re on the trail…will update soon and when we can get reception. Oh- I just asked Diane if she has a message and she asked for everyone to keep all the climbers in their prayers for a safe journey.

UPDATE 1-21

This latest text message from Diane Van Deren:

HEY GUYS MARC AND HEIDI ARRIVED ABOUT AN HOUR AGO WITH DAMIAN WHO WILL BE ONE OF OUR GUIDES ON THE THE MT. DAMIAN IS WILLIES BROTHER AND WAS JUST HELICOPTERED TO SOME OF THE CAMPS TO DROP OFF FOOD ETC FOR OUR FIRST GROUP HIS FACE IS VERY RED FORM THE WINDS ON THE MT. IT WAS A CLEAR DAY ON ACONCAGUA BUT THE WINDS CAN BE A CHALLENGE. SO FYI ROUND ONE  WE ARE MEETING TONIGHT AT 600 GO OVER DETAILS ETC . ITS HOT MAYBE 100 DEGREES TODAY. HEIDI SAID SHE PULLED  THE TEMP  UP ON HER BLACKBERRY.  SO THEY ARE HERE SAFELY OK  XOXOXOXOXOXO SEE THE MAYO GROUP TOMORROW  CANT WAIT   LOVE TO ALL <DI

Members of the Mayo research expedition to Argentina are beginning to arrive in country for this weekend’s launch of the ascent of the hemisphere’s highest point. Extreme athlete Diane Van Deren, the focus of Mayo’s science, sends this message from the southern continent:

Good Morning Argentina!  What a great way to start the morning and head out early with a small breeze and sunshine begging to rise.  It’s 70 degrees here this morning and coming from Colorado with a high of 40 degrees and snow…it’s a heat wave here!  I’m running in this huge park that’s miles in length and width and I got lost even though it’s not far from the hotel! Every time I asked for directions  the louder and more excited folks got! But I made it back…had a wonderful breakfast…what a treat to be here!  Leaving, now, for a trek around the city.  Yes, I have my map.  Adios!  Di

Watch Advancing the Science for more updates…you can also read more about Diane,  this Xtreme medicine research project and Mayo’s investigator Bruce Johnson on page B11 in today’s New York Times. Here is John Branch’s story “Medical Miracle Nears a Milepost” in the online Times.

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Sree Nair, M.D., Ph.D., Recognized by European Society of Nutrition and Metabolism

January 18, 2010 – 10:24 am

K. Sreekumaran Nair, M.D., Ph.D., will receive the Sir David Cuthbertson Medal and deliver the flagship Sir David Cuthbertson Lecture at the 32nd Congress of the European Society of Nutrition and Metabolism (ESPEN) in Nice, France, this September.

“I am honored to receive this award,” says Dr. Nair, an endocrinologist and active clinical investigator. “During my time at Mayo, I’ve been fortunate to have been surrounded by remarkable collaborators, research fellows and laboratory staff — without them, my research would not be possible.”

Research in Dr. Nair’s lab focuses on energy (mitochondria) and protein metabolism, and the pathophysiology of diabetes. Also of interest is the impact of aging on disease — why do certain conditions with genetic predispositions like diabetes, hyperlipidemia or sarcopenia generally appear only as people become older? Answering that question, says Dr. Nair, will teach us how to more effectively manage — and maybe even prevent — those diseases, and will enable people to better enjoy the last years of their lives.

Dr. Nair is co-principal investigator of the Mayo Clinic Center for Translational Science Activities (CTSA). Within the CTSA, he’s director of the Research Resources component and founding director of the Metabolomics Core. In 1999, Dr. Nair was recognized as the David H. Murdock–Dole Food Company Professor of Nutrition Science, and in 2005 was named a Mayo Clinic Distinguished Investigator.

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Major Grant for Alcohol Addiction Studies

January 14, 2010 – 1:25 pm

David Mrazek, M.D., Chair of Psychiatry and Psychology, recently received a $2.5 million grant from the National Institutes of Health to serve as the Program Director of the Mayo Clinic Center for Alcohol Addiction. The center will conduct pharmacogenomic and imaging studies designed to improve our understanding of the response of patients to pharmacological treatment of alcohol addiction.

“By using these additional funds to expand our DNA repository, our pilot study enrollment, and the interface between basic science and individualized treatment of addiction, we will be poised to successfully compete for funding for an additional five years,” says Dr. Mrazek.

The grant was a part of the American Recovery and Reinvestment Act and is intended to develop and implement critical research, stimulate future growth and to advance public health and health care delivery.

Dr. Mrazek became the Chair of the Board of the American Board of Psychiatry and Neurology in this month. The ABPN is a not-for-profit corporation dedicated to serving the public interest and the professions of psychiatry and neurology by promoting excellence in practice through certification and maintenance of certification processes.

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Mayo Clinic CTSA to Host Metabolomics Workshop in April

January 12, 2010 – 5:52 pm

The Mayo Clinic CTSA will host a metabolomics workshop at the Mayo Clinic campus in Rochester, Minn., on April 16. The workshop is aimed at translational science investigators, KL2 and other K-award scholars, and research fellows interested in this emerging field.

National and international visiting faculty, as well as Mayo Clinic faculty, will speak at the workshop. In addition to learning about metabolomics techniques and applications, attendees will have the opportunity to network with colleagues and tour Mayo’s metabolomics facilities. Also outlined will be the novel analytical tools at the Mayo CTSA’s Metabolomics Core.

Metabolomics deals with the measurement of small molecules in biological systems. These small molecule “metabolites,” when examined in healthy and diseased states, can offer insight into metabolic status and biological changes in an organism. Metabolomics has the potential to detect diseases and their progression, monitor response to therapy, and highlight targets for drug design.

For more information and to register, visit the CTSA’s metabolomics workshop Web site.

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Mayo’s Argentine Research Expedition

January 11, 2010 – 4:44 pm

It’s extreme science about extreme athletes and explorers. People who climb mountains – or run up them – provide a great example of what the human body can do. Understanding their physiology in unusual environments will help researchers to understand better how the body works when it’s under the stress of disease and illness.

Cardiology researcher Bruce Johnson, Ph.D., will set up remote monitoring equipment at base camp at Aconcagua — the second highest mountain range in the world — to track vitals on Diane Van Deren, the ultra runner who is scheduled to run up and down the mountain — twice.

Dr. Johnson is no stranger to studying folks in unusual places. He spent part of last year at the South Pole, collecting data on people who work there. In addition to studying Diane, he will also be testing a range of technology that may one day be used to monitor patients remotely. All of this is aimed at improving the ways Mayo can improve patient care for a variety of conditions, both on and off our campuses.

Dr. Bruce Johnson and colleagues at the South Pole

Stay tuned to this blog for updates on this research project as it happens – including posts directly from the scene. For those on Twitter, our hash tag for the project will be  #Xmedicine.

Diane Van Deren

Diane Van Deren and one of her many mountains

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Mayo Investigator Honored for Contributions to Nutrition Research

January 7, 2010 – 1:25 pm

Mayo Clinic nephrologist Rajiv Kumar, M.D., has been honored by the American Society for Nutrition. The Society has announced that Dr. Kumar will receive the E.V. McCollum Award in April at the Experimental Biology 2010 Meeting in Anaheim, California.  The award is presented to, “a clinical investigator who is perceived as a major creative force, actively generating new concepts in nutrition and personally seeing to the execution of studies testing the validity of these concepts.”  The award is named for the pioneering biochemist and vitamin researcher from the University of Wisconsin.

“I am particularly honored to receive this award because it comes from my peers and because it honors the accomplishments of Dr. McCollum, one of the founding leaders in nutrition research,” says Dr. Kumar.

Dr. Kumar has conducted extensive research on phosphate and vitamin D and their impact on health and disease, specifically as they relate to osteoporosis and renal conditions. His work focuses on the regulation of phosphate metabolism, vitamin D and its mechanism of action and the related genetic and proteomic factors involved.

In addition to his primary appointment in nephrology, Dr. Kumar also holds appointments in biochemistry/molecular biology and endocrinology.

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Discovery’s Edge — 2 issues at once

December 22, 2009 – 3:44 pm

We didn’t plan it this way, but because the print edition of Mayo’s research magazine appears twice a year and the online version is quarterly, we have the neat situation of publishing twice the number of science stories this season. Here is the rundown for the online features:

Deep Brain Stimulation – It Boggles the Mind
How a Mayo research team of physicians, scientists and engineers are extending treatments for neurological conditions.

Osteoporosis in Men
Brittle bones, breaks and complications – it happens to men as well and in some cases, with more severe results.

Combat Injuries – Regenerating the Nerves
From the battlefield to the laboratory, Mayo researchers are spearheading nerve regeneration research to help combat vets.

Multiple Myeloma and the Genome
A collaborative and team approach aimed at one of the worst types of cancer.

The Spotlight marks the anniversary of Mayo researchers’ role in the fight against tuberculosis in the 1940s.

Our print issue, which we will send you at no cost if you subscribe, includes 30 pages of full color art and images about Mayo research teams and related news. To subscribe to either the print or online version (or both)  go to the Discovery’s Edge home page.

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Mayo Researchers at Breast Cancer Conference

December 14, 2009 – 12:55 pm

Mayo Clinic’s breast cancer research came in for extra attention recently at the American Association for Cancer Research conference in San Antonio, Texas. Among others, Edith Perez, M.D., conducted a variety of media interviews in addition to her regular presentations on herceptin research. James Ingle, M.D. was also on hand and was featured in an AACR video interview on aromatase inhibitors as adjuvant therapy, that can be viewed here.

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Rochester Epidemiology Project

December 4, 2009 – 12:40 pm

The Rochester Epidemiology Project (aka one of Minnesota’s and the United States’ best, yet hardly noticed, medical resources) is trying to raise its visibility. What is the REP? Probably the largest and oldest  population-based medical consortium in the country. Researchers have been answering medical trend questions, characterizing frequencies of diseases and conditions, and tracking key data for, yes, generations now. It’s been called Rochester’s best guarded secret — though no one has purposely been trying to keep it so. Now, with the launch of a new web site, we hope its legend looms a bit larger.

The overview on the site is typically modest, I think, when it says the REP is one of the few places in the world to do population-based medical research.  It’s one of the top places and one of the most respected. It is the largest of its kind in the nation (did I say that already?) and I suspect if they listed all the research papers generated over the years (instead of just the last few), the site would have to be expanded. Its origins go back to the 1960s, though some of the data go back even further. Congratulations to the REP and the Rochester area community.

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Translational Research’s New Interface

November 19, 2009 – 12:32 pm

Mayo Clinic’s just launched its new and improved “front door” for translational research. The Center for Translational Science Activities at Mayo has launched its new and enhanced web site. Why is that so important? Much of what the CTSAs do is to make medical research relevant to the needs of their communities. This site goes far to help that effort as well as to interface with people who are interested in going into translational research as a career.

Mayo Clinic was one of the first institutions awarded a CTSA grant by NIH — $72 million — to bring research findings into medical practice so they directly impact patients and communities. If you’ve not looked at what Mayo’s CTSA is up to, I urge you to take the opportunity. The CTSA is the integrated model of medical research for the future, breaking down the institutional “silos” in traditional medical centers. At Mayo, we welcome the concept, as integration of research, education and practice has always been part of what we are.

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