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Mayo Clinic Medical Science Blog

Jul 31, 2009 · Leave a Reply

Cocaine Update-Journal cover article

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Just learned that Yang Gao and Dr. Steve Brimijoin of Mayo have the cover article in JPET this month: Transduction of cocaine hydrolase by striatal neurons and non-neural cells after local delivery of viral vector, page 449. This is a continuation of the work that was originally funded by the Minnesota Partnership for Biotechnology and Medical Genomics in which they found an antidote to cocaine poisoning. In these new findings they report a much longer effect for their described approach - at least two months, with lesser effects for up to a year. Now the way is clear for behavioral studies to see if this can be useful in withdrawal in addition to toxicity treatment. Long-term outcome may be a cocaine vaccine.

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