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2 days ago · Research News Roundup--July 2017 (2)

Welcome to the second issue of the Mayo Clinic Research News Roundup. These columns reprise research news releases from the past month, and link readers to those articles, as well as related resources.

Thank you for your continued support of Mayo Clinic Research!

July 16-31, 2017

Besides its original campus in Rochester, Minnesota, this July Mayo Clinic School of Medicine – Arizona Campus opened its doors to an inaugural class of 50 first-year students. The total student body in Arizona will mushroom to 200 when the full four-year program finishes implementation in 2020. The school’s Florida campus is launching third-year and fourth-year programs, with hopes of expanding its Florida campus to a full four-year program in a few short years.

Mayo Clinic’s national medical school model enables students to receive the same learning experiences in basic and clinical sciences at their home campus, but travel among campuses for career exploration, research opportunities, clinical rotations and clerkships across multiple specialties.

Sudden cardiac death, and episodes of fainting and seizures from long QT syndrome are significantly lower than previously thought when patients are diagnosed and treated at a specialty center dedicated to the treatment of genetic heart rhythm diseases, according to Mayo Clinic research published in the Journal of the American College of Cardiology. This is one of the largest studies of long QT syndrome patients – people who have an inherited heart rhythm condition that can potentially cause fast and chaotic heartbeats – evaluated and treated at a single center to analyze these outcomes.


Find research feature stories, videos and news on Discovery’s Edge, Mayo Clinic’s online research magazine.

Cancer-related stories of hope and healing can be found in Forefront, the online version of Mayo Clinic Cancer Center‘s magazine.

Mayo Clinic Radio‘s 1-minute and in-depth discussions of research and practical patient information can be found online or via your local radio station.

Much of our content is available in Spanish as well.

Tue, Aug 1 8:00am · Research News Roundup--July 2017 (1)

We’re trying out a new idea on the blog – the Mayo Clinic Research News Roundup. These columns will reprise research news releases from the past month, and link readers to those articles, as well as related resources.

Thank you for your continued support of Mayo Clinic Research!

July 1-15, 2017

July 14, Mayo Clinic and nference launched a startup company for drug development that will be powered by clinical expertise and artificial intelligence (AI). The company, named Qrativ(pronounced cure-a-tiv) will combine nference’s AI-driven knowledge synthesis platform with Mayo Clinic’s medical expertise and clinical data. Qrativ seeks to discover and develop treatments for diseases with unmet medical need. This effort is being boosted by an $8.3 million Series A financing supported by Matrix Capital Management, Matrix Partners and Mayo Clinic. Qrativ’s initial focus will be on rare diseases and highly targeted patient populations.

More than 4 in 5 opioid prescriptions given after surgery over a recent two-year period at Mayo Clinic exceeded guidelines now in the works, the clinic’s researchers have found. The research, published July 13 in the Annals of Surgery, also highlights a significant difference in opioid prescribing among Mayo Clinic’s Arizona, Florida and Rochester campuses, and within specific surgical procedures. The team of physicians and scientists expect their results will improve care for Mayo Clinic patients and help shape national policy and health care guidelines.

In a new study published in Prosthetics and Orthotics International, Mayo Clinic researchers describe the direct medical costs of falls in adults with a transfemoral amputation. In this type of amputation, the leg is amputated above the knee. This work “provides a comparison for policymakers when evaluating the value of more expensive … technologies,” say the authors.

For patients with diabetes, one reason for hospitalization and unplanned hospital readmission is severe dysglycemia (uncontrolled hyperglycemia – high blood sugar, or hypoglycemia – low blood sugar), says new research published in the Journal of General Internal Medicine.

Mayo Clinic is pleased to announce the launch of Mayo Clinic Proceedings: Innovations, Quality & Outcomes. An open-access, online medical research journal, Mayo Clinic Proceedings: Innovations, Quality & Outcomes is dedicated to “building upon innovations in research, advancing the quality of medical and surgical care, and promoting optimal patient outcomes.”

People with the movement disorder Parkinson’s disease have a much higher risk of the skin cancer melanoma, and vice versa, a Mayo Clinic study finds. While further research is needed into the connection, physicians treating one disease should be vigilant for signs of the other and counsel those patients about risk, the authors say. The findings are published in Mayo Clinic Proceedings.


Find research feature stories, videos and news on Discovery’s Edge, Mayo Clinic’s online research magazine.

Cancer-related stories of hope and healing can be found in Forefront, the online version of Mayo Clinic Cancer Center‘s magazine.

Mayo Clinic Radio‘s 1-minute and in-depth discussions of research and practical patient information can be found online or via your local radio station.

Much of our content is available in Spanish as well.

Mon, Jul 31 8:00am · REGISTER NOW--Transform health care one moment at time

For a few days, you join a community of intensely curious peopleall of whom are eager to explore foundational questions that are otherwise sidelined in standard analyses of health care in the United States. Transform doesn’t shy away from any of it.  
– Lauren Taylor, Co-Author, The American Health Care Paradox, (past Transform speaker)

For ten years Transform has thrived on the expertise and energy of attendees from around the world. Participants influence the course of the conference with compelling questions during unpacking segments, expand the discussion during meet the speaker conversations, and share insights throughout the conference.

Attendees also play a vital role in breakout sessions at Transform. Facilitated by experts who are leading initiatives to make the transformation of health care possible, breakouts provide an opportunity to focus on strategies to address key questions, such as:

What’s Wrong?
By carefully identifying problems, considering all of those affected, and executing quick tests of change, health care teams can stop solution jumping and get to the real root of a problem.
Led by Diane Klein and Tracee Vetting Wolf
Mayo Clinic Center for Innovation

What Counts?
By understanding patient segments and choosing meaningful measures, health care providers can be equipped for new payment models and shape the future of how new models are adopted and used.
Led by Elizabeth Teisberg, Ph.D., and Scott Wallace
Value Institute for Health and Care, University of Texas Dell Medical School

What’s Broken?
Through a carefully designed process to understand imminent payment reform challenges, health care leaders can catalyze the development of a sustainable framework to transform clinical practice. This allows organizations to thrive, rather than merely react, in a risk-based environment.
Led by Robert Nesse, M.D., Lyell Jones Jr., M.D., Kathleen Harrington, John Poe, Allison Matthews, and David Derby
Mayo Clinic

What Matters?
The victories of social movements can provide insight into how people, health care organizations, and policymakers might work together to expand and invent ways of addressing what people and communities need.
Led by Jackie del Castillo and Halima Khan
Nesta Health Lab

We are at a critical moment: the transition to value-based payment, political and policy uncertainty, and challenges of affordability and access are impacting patients, providers, payers, communities, and systems. Transform 2017 will focus on the essential challenge of closing the gap between people and health.

Transform is the health care innovation conference that brings together change agents and decision makers addressing pivotal issues to boldly transform health care. Please join us September 27-29th at the Mayo Civic Center in Rochester, Minnesota.

Register Now!

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Tue, Jul 25 8:00am · New findings from Nursing Research

Everyone knows what nurses do – they care for patients, right?

While providing the best possible patient care is foremost on nurses’ minds at Mayo Clinic (and really, that of all our health care providers), nurses hold all sorts of roles. And some nurses are “doctors,” of the Ph.D. variety.

Linda L. Chlan, Ph.D., R.N., is the associate dean for nursing research at Mayo Clinic, in Rochester, Minnesota.

These nurse scientists form the core of Mayo’s Division of Nursing Research, led by Linda Chlan, R.N., Ph.D., associate dean for Nursing Research. In nursing, research answers important and puzzling clinical questions. Nursing researchers seek to identify and improve strategies and interventions that best  address patients’ needs. Knowledge from nursing research studies informs and guides nursing practice.

One recent study, led by Dr. Chlan, showed that anxiety can be reduced among ICU patients by enabling them to self-administer their own sedative medication. This study was published in the American Journal of Critical Care, and received extra attention across the health care community due to a news release issued by the journal.

Patient-administered sedative medication—just one of a wide range of topics for which Dr. Chlan and her colleagues are building the evidence base to improve patient experience, outcomes and costs.

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Mon, Jul 10 8:00am · Mayo Clinic Proceedings: Innovations, Quality & Outcomes

Mayo Clinic launched a new journal July 5, designed to focus on clinical innovations, quality improvement, and optimal outcomes, in medicine and surgery. Mayo Clinic Proceedings: Innovations, Quality & Outcomes provides new publication opportunities for pioneering and impactful clinical research on factors that affect contemporary health care delivery.

Editor-in-Chief Thomas Gerber, M.D., Ph.D., summarizes the inaugural issue.

The new journal covers a wider range of topics than the general/internal medicine-themed Mayo Clinic ProceedingsMayo Clinic Proceedings: Innovations, Quality & Outcomes is multidisciplinary in scope, too, with an emphasis on areas of medicine and surgery not currently covered by its parent journal.

About Mayo Clinic Proceedings: Innovations, Quality & Outcomes
Mayo Clinic Proceedings: Innovations, Quality & Outcomes(MCP:IQ&O) is an online-only, open access journal that—like its parent journal, Mayo Clinic Proceedings—is sponsored by Mayo Clinic. MCP:IQ&O publishes original research, reviews, commentaries, editorials, and other materials that focus on clinical innovations, quality improvement, and optimal outcomes, in medicine and surgery. The journal welcomes contributions from authors worldwide. http://www.mcpiqojournal.org

About Mayo Clinic Proceedings
The flagship journal of Mayo Clinic and one of the premier peer-reviewed clinical journals in general medicine, Mayo Clinic Proceedings (@MayoProceedings) is among the most widely read and highly cited scientific publications for physicians, with a circulation of approximately 125,000. While the journal is sponsored by Mayo Clinic, it welcomes submissions from authors worldwide, publishing articles that focus on clinical medicine and support the professional and educational needs of its readers. mayoclinicproceedings.org.

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Mon, Jul 3 8:00am · Meet our Surgical Outcomes Research Fellows

The Surgical Outcomes Research Program in the Mayo Clinic Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery selects surgical residents interested in research to become Surgical Outcomes Research Fellows. These fellows take one or two years away from clinical training to receive mentoring in health services research from Elizabeth B. Habermann, Ph.D., and a team of clinical mentors appropriate to the fellow’s area of interest.

Past fellows have published dozens of peer-reviewed publications, speak internationally and nationally, and work toward their shared goal of becoming academic surgeons.

The 2016-2017 Surgical Outcomes Research Fellows are:

Brittany L. Murphy, M.D.

Mariam N. Ali-Mucheru, M.D.

 

 


In the early years of the fellowship, all fellows were located at Mayo Clinic’s campus in Rochester, Minnesota. An additional fellow at Mayo Clinic’s campus in Phoenix/Scottsdale, Arizona, was selected for 2016-2017. Fellows at Mayo Clinic’s campus in Arizona are primarily mentored by David A. Etzioni, M.D.

Past fellows include:

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Fri, Jun 23 8:00am · Meet the Researchers at AcademyHealth Annual Research Meeting

If you’re heading to New Orleans for AcademyHealth’s Annual Research Meeting (ARM), AcademyHealth says it’s a great opportunity to:

  • Learn about the latest emerging evidence.
  • Discover new methods and applications of rigorous and relevant methods.
  • Identify gaps and opportunities in research.
  • Enhance your understanding of the most pressing research policy issues.
  • Connect with peers, expand your community, and identify new collaborators.

We hope that you will do exactly that, and especially take the time to check out what Mayo Clinic is doing across the entire discovery, translation and application continuum as we build the evidence base in health care delivery research.

At the booth from the Mayo Clinic Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, not only will you find more information about Mayo Clinic research, education and career opportunities, but you’ll have a chance to meet some of our researchers.

Sunday, June 25, 2017

11:30 a.m. – Noon Dorin Colibaseanu, M.D.

Dr. Colibaseanu is a colorectal surgeon from Mayo Clinic in Jacksonville, Florida. He is 2017 Kern Health Care Delivery Scholar in the Mayo Clinic Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery.  Dr. Colibaseanu’s research focuses on surgical quality measurement and improvement in health care delivery. He will showcase his work at #ARM2017 during a poster session, featuring his poster: Palliative Care Utilization in Patients with Solid Cancer Tumors: A Retrospective Study.

12:30 – 1 p.m. Lois Krahn, M.D.

Dr. Krahn is a member of Mayo Clinic’s Board of Trustees and Board of Governors and the Deputy Director of Education in the Mayo Clinic Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery. She is a sleep medicine specialist and researcher at Mayo Clinic, in Phoenix/Scottsdale, Arizona.

2 – 2:30 p.m. David Etzioni, M.D.

Dr. Etzioni is a colorectal surgeon at Mayo Clinic, in Phoenix/Scottsdale, Arizona, whose research focuses on the appropriate use of information to reflect surgical patient outcomes. He is a national expert on the measurement, analysis, and interpretation of surgical outcomes data. Dr. Etzioni will be chairing and presenting in a special session at #ARM2017: Post-Operative Outcomes and Quality Improvement in the Era of Big Data.

2:30 – 3 p.m. Robert Cima, M.D.

Dr. Cima is a colorectal surgeon and the medical director of the Mayo Clinic Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery Surgical Outcomes Program.  This program focuses on access, safety, outcomes, and quality metrics and reporting using Mayo Clinic and national data.  Dr. Cima is presenting at #ARM2017 in the special session: Post-Operative Outcomes and Quality Improvement in the Era of Big Data.

3 – 3:30 p.m. Sean Dowdy, M.D.

Dr. Dowdy is a gynecologic surgeon and the Deputy Director of Practice for the Mayo Clinic Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery. His research focuses on improving the quality of surgery delivered to women with gynecologic cancers by reducing complications, accelerating recovery, and improving patient satisfaction. Dr. Dowdy is presenting at #ARM2017 in the special session: Post-Operative Outcomes and Quality Improvement in the Era of Big Data.

Monday, June 26, 2017

8:30 – 9 a.m. Aaron Leppin, M.D. (@aaronleppinmd)

Dr. Leppin’s work focuses on health promotion programs in the community and he is part of Mayo Clinic’s Knowledge and Evaluation Research Unit.  He developed the WellConnect portal, which connects patients, providers, educators and other stakeholders across community health in southeast Minnesota.

Dr. Leppin will present at #ARM2017: The Minnesota Model for Clinical Integration of Health Promotion Programs in the Community: A Model and Technology Demo. In addition, he is presenting a poster: Integrating Community-Based Health Promotion Programs and Primary Care: A Mixed Methods Analysis of Feasibility.

9:30 – 10 a.m. Rozalina McCoy, M.D. (@RozalinaMD)

Dr. McCoy is an endocrinologist, primary care physician, and Kern Health Care Delivery Scholar, whose work focuses on using big data (@OptumLabs) for patient-centered outcomes research in diabetes and chronic disease management. She has two posters at #ARM2017: Recurrent Hospitalizations for Severe Hypoglycemic and Hyperglycemic Events Among U.S. Adults with Diabetes Mellitus, and Adoption of New Glucose-Lowering Therapies: How Are SGLT2 Inhibitors Prescribed and Used Across the U.S.?  Dr. McCoy will also be presenting her work Leveraging New Data Sources for Quality Measurement and Reporting.

10:30 – 11 a.m. Jim Naessens, Sc.D.

Dr. Naessens is the scientific director for the Florida team in the Mayo Clinic Robert D. and Patricia E. Kern Center for the Science of Health Delivery, and he leads the quality and safety arm of the Office of Health Care Practice and Policy in the center. He is a health services researcher interested in issues around the cost and quality of health care and how changes in the way health care is delivered may affect outcomes for patients.  At #ARM2017, Dr. Naessens has two posters: Effect of Adverse Events on Patient Experience Among Hospital Inpatients and Predicting Pediatric Readmissions.

11:30 – Noon Elizabeth Habermann, Ph.D. (@EBHabermann)

Dr. Habermann is the scientific director of the Surgical Outcomes Program in the Mayo Clinic Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery. Her work focuses on the quality of care that surgical patients receive, access to surgical care and surgical specialists, and associated patient outcomes including complications and survival.  She is involved in several sessions during #ARM2017, including serving as session chair for Healthcare Delivery System Factors and Their Relationship to Quality, Health Outcomes and Efficiency of Care. Dr. Habermann is a discussant of Improving Quality and Safety of Pain Management, and speaker at Post-Operative Outcomes and Quality Improvement in the Era of Big Data.

5 – 5:30 p.m. Jeff Sloan, Ph.D.

Dr. Sloan’s research focuses on patient quality of life (QOL), patient-reported outcomes (PROs), and improving patient care by incorporating simple measures of patient QOL into clinical practice. He is a member of Mayo Clinic Cancer Center, and a health services researcher at Mayo Clinic in Rochester, Minnesota. At #ARM2017, Dr. Sloan will be presenting his work on Applying PROs in Clinical Practice.

5:30 – 6 p.m. Nabil Wasif, M.D.

Dr. Wasif is a surgeon and cancer researcher from Mayo Clinic in Phoenix/Scottsdale, Arizona, focusing on malignancies of the gastrointestinal tract, pancreas and breast, as well as melanoma. He is especially interested in cancer databases to look at quality of care, disparities in care, and treatment outcomes. He has a poster at #ARM2017 titled: Disparities in Access to High Volume Hospitals Following Regionalization of Cancer Surgery in the United States.

6:30 – 7 p.m. Molly Moore Jeffery, Ph.D.

Dr. Jeffery is a research associate in Health Care Policy and Research at Mayo Clinic in Rochester, Minnesota. She is a member of the Knowledge and Evaluation Research Unit, and is presenting at #ARM2017: Guideline Concordance, Amount, and Duration of Opioid Prescription Fills: An Analysis of a Commercial and Medicare Advantage Population.

Add these ‘Meet the Researcher’ times to your calendar, and stay tuned for more from @MayoClinic @AcademyHealth #ARM2017.

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Related article: Sharing the evidence, building awareness at AcademyHealth’s Annual Research Meeting

Tue, Jun 20 8:00am · Sharing the evidence, building awareness at AcademyHealth’s Annual Research Meeting

At Mayo Clinic, research is integral to everything we do for patients. While seeking to address the world’s most challenging health care problems, our researchers work hand-in-hand with health care providers and other professionals to build the evidence base for practice transformation.

In the Mayo Clinic Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, we expand this multidisciplinary team science approach beyond the walls of Mayo Clinic, collaborating with groups such as OptumLabs, the High Value Healthcare Collaborative, and the U.S. Food and Drug Administration. Together we seek to improve outcomes, enhance patient experience, and better manage the cost of care; while building and nurturing a healthy care provider workforce.

Part of our charge within the science of health care delivery is to share what we learn, in an effort to accelerate practice transformation for the good of patients everywhere. In addition to publishing in peer-reviewed journals, we present our research at national and international gatherings such as AcademyHealth’s Annual Research Meeting (ARM).

#ARM2017 features Mayo Clinic researchers from across the entire discovery, translation and application continuum of health care delivery research. Activities range from poster presentations to leading discussions, informal ‘Meet the Researcher’ sessions at the center booth, and hosting a special session: Post-Operative Outcomes and Quality Improvement in the Era of Big Data.

If you’re at #ARM2017, June 25-27, 2017, New Orleans, Louisiana, you can check out these events in person. Abstracts and more information are available on the AcademyHealth Annual Research Meeting agenda website.

Mayo Clinic at AcademyHealth Annual Research Meeting 2017:

Sunday, June 25th

  • 10:30 a.m. – Noon, Room: Bolden 2, Aaron Leppin, M.D. (@aaronleppinmd)

The Minnesota Model for Clinical Integration of Health Promotion Programs in the Community: A Model and Technology Demo

Healthcare Delivery System Factors and Their Relationship to Quality, Health Outcomes and Efficiency of Care

  • 12:15 – 1:45 p.m., Poster Session, Elite Hall
  1. Palliative Care Utilization in Patients with Solid Cancer Tumors: A Retrospective Study Dorin Colibaseanu, M.D.
  2. Patient Portal Use Among Cancer Patients: Does It Matter during Hospitalization? – Duaa Aljabri
  • 4 p.m. – 5:30 p.m., Room: Celestin G/H, Special Session

Post-Operative Outcomes and Quality Improvement in the Era of Big Data

David Etzioni, M.D., with Robert Cima, M.D., Sean Dowdy, M.D., Elizabeth Habermann, Ph.D., and Cornelius Thiels, D.O. (@ThielsCA)


Monday, June 26th

  • 8 a.m. – 9:15 a.m., Poster Session, Elite Hall
  1. Trends in High-Cost Patients in the U.S. from 1996 through 2013: Evidence from Medical Expenditure Panel Survey DataBijan Borah, Ph.D.
  2. The Association Between Hospital Characteristics and Readmission for Endometrial Cancer Patients Undergoing Surgery in the U.S. – Bijan Borah, Ph.D.
  3. Recurrent Hospitalizations for Severe Hypoglycemic and Hyperglycemic Events Among U.S. Adults with Diabetes MellitusRozalina McCoy, M.D. (@RozalinaMD)
  4. Adoption of New Glucose-Lowering Therapies: How Are SGLT2 Inhibitors Prescribed and Used Across the U.S.? – Rozalina McCoy, M.D.
  5. Effect of Adverse Events on Patient Experience Among Hospital Inpatients – James Naessens, Sc.D.
  6. Predicting Pediatric ReadmissionsJim Naessens, Sc.D.
  7. Efficacy of Clinical Alerts to Decrease Inappropriate Urinary Cultures in Catheterized PatientsMark Parkulo, M.D.
  8. Linking Administrative Data with a Prescription Registry to Understand Opioids Prescribing Patterns and Target Quality Improvement Efforts in a Large Integrated Practice – Priya Ramar
  9. Deviation from the FDA Dosing Labels for Non-Vitamin K Antagonist Oral Anticoagulants May be Associated with Reduced Effectiveness or Safety – Stephanie Schilz
  10. A Profiling of High Cost Episodes Under Bundled Payment Models for Lower Extremity Joint Replacements – Kristy Swanson
  • 9:30 a.m. – 11 a.m., Room: Imperial 5A/B, Elizabeth Habermann, Ph.D., Discussant

Improving Quality and Safety of Pain Management

  • 3:15 p.m. – 4:45 p.m., Room: Imperial 5C/D, Rozalina McCoy, M.D. and Kristi Swanson

Leveraging New Data Sources for Quality Measurement and Reporting

Applying PROs in Clinical Practice

  • 6:30 – 8 p.m., Poster Session, Elite Hall
  1. Trends and Disparities in the Use of Palliative Care for Stage IV Cancer Patients in the United StatesMariam Ali-Mucheru, M.D.
  2. Integrating Community-Based Health Promotion Programs and Primary Care: A Mixed Methods Analysis of Feasibility – Aaron Leppin, M.D.
  3. Interventions for Diabetes Management Among Patients with Limited English Proficiency: A Systematic Review and Meta-Analysis Jane Njeru, M.B.,Ch.B.
  4. Racial and Ethnic Disparities Among Hospitalized Adults with Diabetes in the U.S.: A Nationwide Population-Based Study – Rene Rodriguez-Gutierrez, M.D.
  5. Racial and Ethnic Disparities in 30-Day Hospital Readmission Among Patients with Diabetes: A Nationwide Population-Based Study – Rene Rodriguez-Gutierrez, M.D.
  6. Effects of Health Insurance Type on the Cost and Use of Catheter Ablation for Atrial Fibrillation – Stephanie Schilz
  7. Increase in Anaphylaxis Incidence and Severity in the United States, 2005-2014 – Holly Van Houten
  8. National Trends in Emergency Department Visits and Hospitalizations for Food-Induced Anaphylaxis in US Children – Holly Van Houten
  9. Disparities in Access to High Volume Hospitals Following Regionalization of Cancer Surgery in the United StatesNabil Wasif, M.D.

Tuesday, June 27th

  • 8 a.m. – 9:30 a.m., Room: Strand 12, Molly Moore Jeffery, Ph.D.

Guideline Concordance, Amount, and Duration of Opioid Prescription Fills: An Analysis of a Commercial and Medicare Advantage Population

Add these event times to your calendar, and stay tuned for more from @MayoClinic @AcademyHealth #ARM2017.

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