Advancing the Science

Mayo Clinic Medical Science Blog

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5 days ago · Expanding our fold - Mayo Clinic's newest research related websites

At Mayo Clinic, research is integral to everything we do. We would be unable to offer the highest possible levels of care and continually improve the practice of medicine without research, and the education programs and processes to make it a reality.

We are pleased to introduce some of our newest programs – or in some cases – simply their entrée into online presence. In addition to new sites, we constantly are updating current content to give a glimpse of new research initiatives, completed projects and noteworthy findings. Here are some new sites, as well as some with fresh content and updated information:

  • Students and faculty in the inaugural SPARK class.

    SPARK Research Mentorship Program, aka the Science Program for the Advancement of Research Knowledge, began in Summer 2017 as an opportunity for students to be mentored by some of the top researchers in the world..

The SPARK Research Mentorship Program at Mayo Clinic’s campus in Jacksonville, Florida, provides high school students in Duval and St. Johns counties mentored research experiences in world-class laboratories. This program enables students to develop a basic understanding of scientific research and produce a highly competitive science fair project.

 

In the Brain Tumor Stem Cell Research Lab, Alfredo Quinones-Hinojosa, M.D. and his team study the molecular pathways of glioblastoma, chordoma and metastatic brain cancer to find new therapies for patients.

Work in the lab includes novel therapeutics for glioblastoma, cell migration and invasion, cellular therapy, models of brain and spine cancers, and maintenance of a human tissue bank.

 

The gall bladder is highlighted in this illustration of a baby’s internal organs.

In his lab,  Lewis R. Roberts, M.D. and his team study hepatocellular carcinoma, cholangiocarcinoma and gallbladder cancer.  The team’s research goals include identifying and targeting cancer genes to improve prevention, diagnosis and treatment of hepatobiliary cancers.

They also are developing culturally appropriate health education interventions for hepatitis B and hepatitis C in the Somali community in Rochester, Minnesota, and beyond.

 

 The Nicotine Research Program at Mayo Clinic studies the best methods to help people quit using tobacco and strategies to prevent people from starting at all.

It is a key component of the Mayo Clinic Nicotine Dependence Center, one of the first centers in the country to focus exclusively on treatments for tobacco dependence.

Thanks for visiting. Keep watching Advancing the Science for the latest Mayo Clinic research news and information.

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Thu, Sep 14 8:00am · Research News Roundup--August 2017

The Mayo Clinic Research News Roundup includes brief summaries and links to research news releases from the past month. It also connects readers to related resources. Read on for more information from Mayo Clinic Research!

August 2017

For the first time, Mayo Clinic researchers and colleagues present data on how nervous system tumors, called neuroblastomas, spread.  Their paper, published in Cancer Cell, clarifies the relationship between two genes that fuel the aggressive spread of neuroblastomas.

Neuroblastoma is a cancer that most commonly affects children age 5 or younger, though it may rarely occur in older children.

Z-endoxifen, a potent derivative of the drug tamoxifen, could itself be a new treatment for the most common form of breast cancer in women with metastatic disease. This finding was reported from a clinical trial conducted by researchers at Mayo Clinic and the National Cancer Institute, and published in the Journal of Clinical Oncology.

new study published in MenopauseThe Journal of The North American Menopause Society has found that low-dose hormone therapy may be effective in easing sleep issues for women in perimenopause and early menopause. The goal of the study was twofold: find out how two forms of hormone therapy affect sleep quality and assess the ties between hot flashes, sleep quality and hormone therapy.

new study has found that a condition that threatens the lives of some pregnant women and the fetus may continue to put the mother at risk later in life.Mayo Clinic researchers found that women with a history of pre-eclampsia are more likely to face atherosclerosis – hardening and narrowing of the arteries – decades after their pregnancy. The findings are published in the September issue of Mayo Clinic Proceedings.

Mayo Clinic researchers have reported a causal link between senescent cells – the cells associated with aging and age-related disease – and bone loss in mice. Targeting these cells led to an increase in bone mass and strength. The findings appear online in Nature Medicine.

Mayo Clinic researchers have identified a new cause of treatment resistance in prostate cancer. Their discovery also suggests ways to improve prostate cancer therapy. The findings appear in Nature Medicine.

In the publication, the authors explain the role of mutations within the SPOP gene on the development of resistance to one class of drugs. SPOP mutations are the most frequent genetic changes seen in primary prostate cancer. These mutations play a central role in the development of resistance to drugs called BET-inhibitors.

Mayo Clinic researchers, along with colleagues at the University of Iowa, report that a human gut microbe discovered at Mayo Clinic may help treat autoimmune diseases, such as multiple sclerosis. The findings appear in Cell Reports.


Find research feature stories, videos and news on Discovery’s Edge, Mayo Clinic’s online research magazine.

Cancer-related stories of hope and healing can be found in Forefront, the online version of Mayo Clinic Cancer Center‘s magazine.

Mayo Clinic Radio‘s 1-minute and in-depth discussions of research and practical patient information can be found online or via your local radio station.

Much of our content is available in Spanish as well.

Thu, Aug 17 8:00am · Research News Roundup--July 2017 (2)

Welcome to the second issue of the Mayo Clinic Research News Roundup. These columns reprise research news releases from the past month, and link readers to those articles, as well as related resources.

Thank you for your continued support of Mayo Clinic Research!

July 16-31, 2017

Besides its original campus in Rochester, Minnesota, this July Mayo Clinic School of Medicine – Arizona Campus opened its doors to an inaugural class of 50 first-year students. The total student body in Arizona will mushroom to 200 when the full four-year program finishes implementation in 2020. The school’s Florida campus is launching third-year and fourth-year programs, with hopes of expanding its Florida campus to a full four-year program in a few short years.

Mayo Clinic’s national medical school model enables students to receive the same learning experiences in basic and clinical sciences at their home campus, but travel among campuses for career exploration, research opportunities, clinical rotations and clerkships across multiple specialties.

Sudden cardiac death, and episodes of fainting and seizures from long QT syndrome are significantly lower than previously thought when patients are diagnosed and treated at a specialty center dedicated to the treatment of genetic heart rhythm diseases, according to Mayo Clinic research published in the Journal of the American College of Cardiology. This is one of the largest studies of long QT syndrome patients – people who have an inherited heart rhythm condition that can potentially cause fast and chaotic heartbeats – evaluated and treated at a single center to analyze these outcomes.


Find research feature stories, videos and news on Discovery’s Edge, Mayo Clinic’s online research magazine.

Cancer-related stories of hope and healing can be found in Forefront, the online version of Mayo Clinic Cancer Center‘s magazine.

Mayo Clinic Radio‘s 1-minute and in-depth discussions of research and practical patient information can be found online or via your local radio station.

Much of our content is available in Spanish as well.

Tue, Aug 1 8:00am · Research News Roundup--July 2017 (1)

We’re trying out a new idea on the blog – the Mayo Clinic Research News Roundup. These columns will reprise research news releases from the past month, and link readers to those articles, as well as related resources.

Thank you for your continued support of Mayo Clinic Research!

July 1-15, 2017

July 14, Mayo Clinic and nference launched a startup company for drug development that will be powered by clinical expertise and artificial intelligence (AI). The company, named Qrativ(pronounced cure-a-tiv) will combine nference’s AI-driven knowledge synthesis platform with Mayo Clinic’s medical expertise and clinical data. Qrativ seeks to discover and develop treatments for diseases with unmet medical need. This effort is being boosted by an $8.3 million Series A financing supported by Matrix Capital Management, Matrix Partners and Mayo Clinic. Qrativ’s initial focus will be on rare diseases and highly targeted patient populations.

More than 4 in 5 opioid prescriptions given after surgery over a recent two-year period at Mayo Clinic exceeded guidelines now in the works, the clinic’s researchers have found. The research, published July 13 in the Annals of Surgery, also highlights a significant difference in opioid prescribing among Mayo Clinic’s Arizona, Florida and Rochester campuses, and within specific surgical procedures. The team of physicians and scientists expect their results will improve care for Mayo Clinic patients and help shape national policy and health care guidelines.

In a new study published in Prosthetics and Orthotics International, Mayo Clinic researchers describe the direct medical costs of falls in adults with a transfemoral amputation. In this type of amputation, the leg is amputated above the knee. This work “provides a comparison for policymakers when evaluating the value of more expensive … technologies,” say the authors.

For patients with diabetes, one reason for hospitalization and unplanned hospital readmission is severe dysglycemia (uncontrolled hyperglycemia – high blood sugar, or hypoglycemia – low blood sugar), says new research published in the Journal of General Internal Medicine.

Mayo Clinic is pleased to announce the launch of Mayo Clinic Proceedings: Innovations, Quality & Outcomes. An open-access, online medical research journal, Mayo Clinic Proceedings: Innovations, Quality & Outcomes is dedicated to “building upon innovations in research, advancing the quality of medical and surgical care, and promoting optimal patient outcomes.”

People with the movement disorder Parkinson’s disease have a much higher risk of the skin cancer melanoma, and vice versa, a Mayo Clinic study finds. While further research is needed into the connection, physicians treating one disease should be vigilant for signs of the other and counsel those patients about risk, the authors say. The findings are published in Mayo Clinic Proceedings.


Find research feature stories, videos and news on Discovery’s Edge, Mayo Clinic’s online research magazine.

Cancer-related stories of hope and healing can be found in Forefront, the online version of Mayo Clinic Cancer Center‘s magazine.

Mayo Clinic Radio‘s 1-minute and in-depth discussions of research and practical patient information can be found online or via your local radio station.

Much of our content is available in Spanish as well.

Mon, Jul 31 8:00am · REGISTER NOW--Transform health care one moment at time

For a few days, you join a community of intensely curious peopleall of whom are eager to explore foundational questions that are otherwise sidelined in standard analyses of health care in the United States. Transform doesn’t shy away from any of it.  
– Lauren Taylor, Co-Author, The American Health Care Paradox, (past Transform speaker)

For ten years Transform has thrived on the expertise and energy of attendees from around the world. Participants influence the course of the conference with compelling questions during unpacking segments, expand the discussion during meet the speaker conversations, and share insights throughout the conference.

Attendees also play a vital role in breakout sessions at Transform. Facilitated by experts who are leading initiatives to make the transformation of health care possible, breakouts provide an opportunity to focus on strategies to address key questions, such as:

What’s Wrong?
By carefully identifying problems, considering all of those affected, and executing quick tests of change, health care teams can stop solution jumping and get to the real root of a problem.
Led by Diane Klein and Tracee Vetting Wolf
Mayo Clinic Center for Innovation

What Counts?
By understanding patient segments and choosing meaningful measures, health care providers can be equipped for new payment models and shape the future of how new models are adopted and used.
Led by Elizabeth Teisberg, Ph.D., and Scott Wallace
Value Institute for Health and Care, University of Texas Dell Medical School

What’s Broken?
Through a carefully designed process to understand imminent payment reform challenges, health care leaders can catalyze the development of a sustainable framework to transform clinical practice. This allows organizations to thrive, rather than merely react, in a risk-based environment.
Led by Robert Nesse, M.D., Lyell Jones Jr., M.D., Kathleen Harrington, John Poe, Allison Matthews, and David Derby
Mayo Clinic

What Matters?
The victories of social movements can provide insight into how people, health care organizations, and policymakers might work together to expand and invent ways of addressing what people and communities need.
Led by Jackie del Castillo and Halima Khan
Nesta Health Lab

We are at a critical moment: the transition to value-based payment, political and policy uncertainty, and challenges of affordability and access are impacting patients, providers, payers, communities, and systems. Transform 2017 will focus on the essential challenge of closing the gap between people and health.

Transform is the health care innovation conference that brings together change agents and decision makers addressing pivotal issues to boldly transform health care. Please join us September 27-29th at the Mayo Civic Center in Rochester, Minnesota.

Register Now!

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Tue, Jul 25 8:00am · New findings from Nursing Research

Everyone knows what nurses do – they care for patients, right?

While providing the best possible patient care is foremost on nurses’ minds at Mayo Clinic (and really, that of all our health care providers), nurses hold all sorts of roles. And some nurses are “doctors,” of the Ph.D. variety.

Linda L. Chlan, Ph.D., R.N., is the associate dean for nursing research at Mayo Clinic, in Rochester, Minnesota.

These nurse scientists form the core of Mayo’s Division of Nursing Research, led by Linda Chlan, R.N., Ph.D., associate dean for Nursing Research. In nursing, research answers important and puzzling clinical questions. Nursing researchers seek to identify and improve strategies and interventions that best  address patients’ needs. Knowledge from nursing research studies informs and guides nursing practice.

One recent study, led by Dr. Chlan, showed that anxiety can be reduced among ICU patients by enabling them to self-administer their own sedative medication. This study was published in the American Journal of Critical Care, and received extra attention across the health care community due to a news release issued by the journal.

Patient-administered sedative medication—just one of a wide range of topics for which Dr. Chlan and her colleagues are building the evidence base to improve patient experience, outcomes and costs.

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Mon, Jul 10 8:00am · Mayo Clinic Proceedings: Innovations, Quality & Outcomes

Mayo Clinic launched a new journal July 5, designed to focus on clinical innovations, quality improvement, and optimal outcomes, in medicine and surgery. Mayo Clinic Proceedings: Innovations, Quality & Outcomes provides new publication opportunities for pioneering and impactful clinical research on factors that affect contemporary health care delivery.

Editor-in-Chief Thomas Gerber, M.D., Ph.D., summarizes the inaugural issue.

The new journal covers a wider range of topics than the general/internal medicine-themed Mayo Clinic ProceedingsMayo Clinic Proceedings: Innovations, Quality & Outcomes is multidisciplinary in scope, too, with an emphasis on areas of medicine and surgery not currently covered by its parent journal.

About Mayo Clinic Proceedings: Innovations, Quality & Outcomes
Mayo Clinic Proceedings: Innovations, Quality & Outcomes(MCP:IQ&O) is an online-only, open access journal that—like its parent journal, Mayo Clinic Proceedings—is sponsored by Mayo Clinic. MCP:IQ&O publishes original research, reviews, commentaries, editorials, and other materials that focus on clinical innovations, quality improvement, and optimal outcomes, in medicine and surgery. The journal welcomes contributions from authors worldwide. http://www.mcpiqojournal.org

About Mayo Clinic Proceedings
The flagship journal of Mayo Clinic and one of the premier peer-reviewed clinical journals in general medicine, Mayo Clinic Proceedings (@MayoProceedings) is among the most widely read and highly cited scientific publications for physicians, with a circulation of approximately 125,000. While the journal is sponsored by Mayo Clinic, it welcomes submissions from authors worldwide, publishing articles that focus on clinical medicine and support the professional and educational needs of its readers. mayoclinicproceedings.org.

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Mon, Jul 3 8:00am · Meet our Surgical Outcomes Research Fellows

The Surgical Outcomes Research Program in the Mayo Clinic Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery selects surgical residents interested in research to become Surgical Outcomes Research Fellows. These fellows take one or two years away from clinical training to receive mentoring in health services research from Elizabeth B. Habermann, Ph.D., and a team of clinical mentors appropriate to the fellow’s area of interest.

Past fellows have published dozens of peer-reviewed publications, speak internationally and nationally, and work toward their shared goal of becoming academic surgeons.

The 2016-2017 Surgical Outcomes Research Fellows are:

Brittany L. Murphy, M.D.

Mariam N. Ali-Mucheru, M.D.

 

 


In the early years of the fellowship, all fellows were located at Mayo Clinic’s campus in Rochester, Minnesota. An additional fellow at Mayo Clinic’s campus in Phoenix/Scottsdale, Arizona, was selected for 2016-2017. Fellows at Mayo Clinic’s campus in Arizona are primarily mentored by David A. Etzioni, M.D.

Past fellows include:

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