Bob Nellis @bobnellis
Activity by Bob Nellis @bobnellis
A collaboration of 32 researchers in seven countries, led by scientists at Mayo Clinic’s campus in Florida, found that a mutation in only one allele of a Parkinson’s gene, known as PINK1, increases the risk of early-onset disease. The finding, published recently in the journal Brain, addresses a longstanding debate about whether individuals need to inherit two copies of the mutation for an early form of the disease to occur.
The familial form of early-onset Parkinson’s, affecting patients as soon as age 45, is known to occur in individuals with mutations in both inherited alleles of the PINK1 (PTEN-induced putative kinase 1) gene. “This study showed [...]
“I have to tell you that the sheer intellectual joy of finding out how life works is really cool.” – the late Susan Lindquist, Ph.D., pioneering genetic scientist
This last line from Dr. Lindquist’s obituary in the Sunday New York Times struck me as a timeless statement of enthusiasm and dedication. Dr. Lindquist graduated from Illinois and Harvard and went on to explain how genetic mechanisms work behind such conditions as Parkinson’s and Alzheimer’s.
Just hours after reading the Times, I received the link to the new video about Mayo’s role in creating scientists like Dr. Lindquist. I was thinking of her words as I watched it.
I can assure you, the enthusiasm in this footage is not staged or [...]
The core group of Mayo Clinic researchers that moved their lab to the base camp at Mount Everest to study heart disease and aging are at it again, this time in Africa. Along with a party of nearly 35, they will be climbing Mt. Kilimanjaro, obtaining scientific data from the climbers along the way.
Led by Mayo physiologist Bruce Johnson, Ph.D. and joined by Amine Issa, Ph.D., Courtney Wheatley, Ph.D., and Jan Stepanek, M.D., among others, the group will monitor climbers’ heart rates, oxygen saturation, movement, energy expenditure, skin temperature and the quality of their sleep. They’ll also conduct ultrasound scanning to determine differences in younger and older climbers as they react to the altitude.
From Taiwan to Texas, anyone who has anything to do with biosciences is here in San Francisco to hear speakers, attend education sessions, but mostly to network and make contacts for business and research. Mayo Clinic is here along with Destination Medical Center in Minnesota to talk about our research activities and make a major announcement later today. Mayo's research centers are represented in the Minnesota Pavilion at the conference and by several of our scientists and leaders.
We are spreading the word about Mayo being the NIH’s pick for the national biobank . It was announced [...]
On May 17, 2016, the U.S. Food and Drug Administration granted accelerated approval to nivolumab (Opdivo®) for the treatment of patients with classical Hodgkin lymphoma (cHL) that has relapsed or progressed after autologous hematopoietic stem cell transplantation.
Nivolumab also received a breakthrough therapy designation for the treatment of relapsed or refractory cHL after failure of autologous HSCT and brentuximab vedotin. Nivolumab also has orphan drug status for the treatment of Hodgkin’s lymphoma under FDA's accelerated approval program.
Much of the credit for these achievements is due to the work of Stephen Ansell, M.D., Ph.D. of Mayo Clinic. Dr. Ansell led a multi-institution phase I clinical trial of nivolumab which found the immune-boosting drug [...]
Mayo Clinic rheumatologist Dr. Timothy Niewold has received the Lupus Foundation of America’s Mary Betty Stevens Young Investigator Prize for his research on the autoimmune disease lupus.
Dr. Niewold accepted his award Nov. 8 at a reception held by the foundation to coincide with the American College of Rheumatology's annual scientific meeting in San Francisco.
Dr. Niewold’s research “is helping us better understand the causes of lupus and its complications, getting us closer to new and improved ways to treat lupus and the organ damage it creates," says Dr. Gary Gilkeson, professor of medicine/microbiology and immunology at the Medical University of South Carolina and the chair the Lupus Foundation of America's Medical-Scientific [...]
The American Association of Physicists in Medicine (AAPM) has announced the election of Mayo Clinic’s Stephen Riederer, Ph.D., as a Fellow of the association. The category of Fellow honors members who have distinguished themselves by their contributions in research, education or leadership in the medical physics community. The award was presented at the annual meeting of the AAPM in July.
Dr. Riederer has been the Director of the MR Laboratory and a member of the Physics Division of the Department of Radiology of Mayo Clinic in Rochester since 1988. His research interests are in the technical development of magnetic resonance imaging (MRI). This includes use of [...]
Mitochondrial disease has been one of the toughest conditions in medicine. It primarily impacts children inheriting the condition, leaving few if any treatment options. Today, a collaborative group of researchers -- including those from Mayo Clinic's Center for Regenerative Medicine, report they have found a way to eliminate the fatal mutations the inherited DNA leaves in cells. The findings appear in the journal Nature.
This is a proof-of-concept study, but it paves the way toward the long search for a therapy.
The announcement from the Oregon University of Health & Science describes the breakthrough:
"The scientists successfully used mitochondrial replacement to create an [...]
Two Mayo Clinic psychiatrists have been recognized for their contributions to the study, diagnosis, and treatment of depression and bipolar disorder. Paul Croarkin, D.O., and Mark Frye, M.D., were both presented with the Depression and Bipolar Support Alliance’s (DBSA) highest honors for members of the scientific community: Gerald L. Klerman Awards. The Klerman awards are named for the late Gerald L. Klerman, a psychiatrist and expert on depression.
Dr. Paul Croarkin is the Gerald L. Klerman Young Investigator Award recipient. Dr. Croarkin received his medical degree at the University of North Texas Health Science Center at University of North Texas. [...]
That question is coming up here at BIO 2015 in Philadelphia. People have heard about Destination Medical Center, the long range economic development initiative underway in Rochester, MN. But at the center of the futuristic images on the TV screens here, is the picture of Discovery Square. It's more than an artist's conception says Jamie Rothe, who is representing DMC at this international conference.
"It's both a physical location in the middle of Rochester and a virtual location," she explained. "Some of the visioning is still going on and we will have a pretty clear idea at the end of this year, but it's going to reflect the integration of science, technology, health [...]
The Philadelphia Convention Center is awash with devices, large and small molecules, bio-generators and an endless stream of technologies I can’t hope to explain. Over 17,000 people are here to hear about the latest innovations, inventions, discoveries and ideas, but mostly they hope to make deals. Most American states and industrialized countries are here touting their technology strengths. Even some small island nations have booths declaring that they are “the new biotech hub.” BIO 2015 is essentially a trade show, but instead of cars or computers, the commodity is whatever can be commercialized from last year’s scientific discovery or engineering feat. Some outfits are toddlers in the business of science - start up companies with a [...]
At Mayo Clinic, the road to new treatments often begins in the laboratory. For over 100 years, Mayo scientists and physicians have worked together to advance care through medical science. That tradition of leadership by discovery is the Center for Biomedical Discovery. Established to sustain and grow Mayo’s expertise and build on its foundation of discovery science, this strategic research center coordinates team-based investigation of the biological processes governing disease.
The center is directed by Mark McNiven, Ph.D., a veteran cell biology researcher who spent a decade as the chair of Mayo’s Department of Biochemistry and Molecular Biology. Under his leadership, diverse teams of researchers are roadmapping disease to improve health. “Our center [...]
Sundeep Khosla, M.D., has been appointed to the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) advisory council. The NIAMS advisory council is responsible for giving advice to the institute on policy issues as well as making recommendations for research proposals.
Dr. Khosla, director and principal investigator in the Mayo Clinic Center for Clinical and Translational Science (CCaTS) since 2013, is a former president of the American Society for Bone and Mineral Research. He also serves as the chair of the Governance Committee of the National Bone Health Alliance and is currently the dean for clinical and translational science at [...]
Treatment for HIV should begin right at the point of diagnosis. That’s the conclusion of a major international clinical study funded by the National Institutes of Health. The Strategic Timing of AntiRetroviral Treatment (START) study is a randomized clinical trial operating on 215 sites in 35 countries, of which Mayo Clinic is one, funded by the National Institute of Health and conducted by the International Network for Strategic Initiatives in Global HIV Trials (INSIGHT).
Mayo infectious disease specialist and HIV researcher Zelalem Temesgen, M.D., says this is the first clear-cut confirmation that U.S. treatment guidelines should become a global model in the [...]
The title is the key message of Mark Frye, M.D,, head of Mayo Clinic's department of psychiatry and psychology today to a group of 20 top medical journalists in Rochester, MN. Just in this morning from the national psychiatry conference in Toronto, Dr. Frye told fellows from the National Press Club Foundation how precision medicine testing can alert physicians as to the appropriate medication for someone with bipolar disorder and also serve as a diagnostic tool. He also outline how Mayo's Bipolar Biobank is helping in research on new treatments for bipolar disorder.
He told the reporters that a person who has one bipolar manic episode has a 90 percent chance of having another, and [...]
A second-year student at Mayo Medical School -- Soyun (S. Michelle) Hwang -- has been selected by the Howard Hughes Medical Institute (HHMI) to receive a year-long fellowship to conduct mentored biomedical research. Hwang will be mentoring at Mayo Clinic with Jennifer Westendorf, Ph.D., in orthopedic surgery. She will purse her interest in reconstructive surgery, which overlaps with surgical fields like orthopedics. She met Dr. Westendorf at the Perry Initiative, a national event aimed at diversifying the field of orthopedics.
“This is a phenomenal opportunity,” Hwang says. “I conducted proteomics research for 5 to 6 years in muscle diseases prior to coming to Mayo and I have always regarded research as one [...]
A team of Mayo Clinic ophthalmologists have validated what they are calling a user-friendly computer program for pediatric vision testing. Tomohiko Yamada, O.D. and colleagues tested the the Jaeb Visual Acuity Screener (JVAS) - a computerized test -- on 175 children between 3 and 7 years old. After that, they were also tested by an expert ophthalmologist using conventional methods. The screening test is fast -- an average of only 84 seconds to obtain the crucial information. It's also fairly accurate. Compared to the physician exam, the computer test had only 9 to 17 percent falls positives, depending on the screen criteria. And it uses an algorithm that helps prevent tester bias.
Why is something like [...]
Richard Joseph, M.D., an oncologist specializing in melanoma at Mayo Clinic’s Florida campus, has been named the 2015 recipient of the “Doctor of the Year Award” presented by the Melanoma International Foundation (MIF). Founded in 2003, MIF is a non-profit organization whose vision is a future where top-notch melanoma treatment is accessible to all patients globally. Now in its tenth year, the annual award not only recognizes a physician involved in clinical research that is on the cutting edge of melanoma treatment, but who also exhibits a caring attitude towards his/her patients.
Dr. Joseph is actively involved in multiple leading edge clinical [...]
A research group led by Mayo Clinic neuroscientist Eugenia Trushina, Ph.D, has investigated whether treatment with a small molecule CP2 can prevent the debilitating effects of Alzheimer’s disease in three animal models of familial Alzheimer's, an inherited neurodegenerative disorder with symptoms of progressive cognitive decline in aging populations.
There is no cure for Alzheimer's in humans, and with no treatment aimed to prevent or stem the disease, it is estimated that 100 million people might suffer from Alzheimer's by 2050.
Dr. Trushina and her colleagues have shown that, by mildly inhibiting mitochondrial complex I with CP2, they reduce the levels of the biomarkers amyloid [...]
Mayo Clinic's Center for Individualized Medicine -- with the University of Illinois at Urbana-Champaign and the University of Chicago -- is establishing a National Science Foundation Industry/University Collaborative Research Center called the Center for Computational Biotechnology and Genomic Medicine, or CCBGM. The goal is to study the applicability, timeliness, efficiency, and accuracy of the computational infrastructure that will address pressing genome-based challenges, through collaborative projects that include two or more of the member institutions. A key element of this NSF funding model is to recruit industry partners into the Center as a way to fund the research. The CCBGM recently hosted a planning meeting for university staff and representatives from 27 companies in primarily the biotech and computer [...]