Bob Nellis (@bobnellis)
Activity by Bob Nellis
Physicians have long known that people with rheumatoid arthritis and other rheumatic conditions such as lupus are more likely to die at younger ages than are those without these conditions. Even with advances in treatment, the gap in life expectancy remains.
No one knew why until 15 years ago. That’s when researchers at Mayo Clinic helped establish that people with rheumatoid arthritis have a greater chance of developing various types of cardiovascular disease.
“We now know that rheumatoid arthritis is associated with an increased risk of heart and vascular disease,” says senior researcher Sherine E. Gabriel, M.D., a rheumatologist and epidemiologist in
Early in the 20th century, a desperate group of patients began appearing at Mayo Clinic in the hope that the specialists there could keep them alive. Mostly children and younger adults, they had been afflicted with a condition that only years before would have been a death sentence — type I diabetes.
Doctors at Mayo, led by endocrinologist and researcher Russell Wilder, M.D., and a handful of other centers across the country had found a drastic, but feasible method of saving many of them from this deadly disease. Dr. Wilder and his colleague, Walter Boothby, M.D., had formulated a special ketogenic diet.
Consisting of a precise proportion of carbohydrates, proteins and fats determined by [...]
Hours of study, lectures to attend, research to complete, labs to monitor, data to analyze, papers to write, new solutions to old problems to noodle on. It’s just another day in the life of a biomedical research student. The to-do list never seems to end. Morning to night, seven days a week.
The path to becoming a biomedical researcher is not for the fainthearted. It requires years of study, an insatiable curiosity and unflagging persistence in the face of failure.
A Ph.D. candidate at Mayo Graduate School, Katherine A. Hartjes says traveling that long road has been worth it. She has [...]
Big data is a term with uncertain roots, and variable usage, but one which paints a picture of extremely large amounts of information, complex and disparate, that is difficult to analyze using traditional tools. Other challenges with big data include collection and storage, sorting and searching, sharing and individual privacy – just because you have massive amounts of information doesn’t mean you can use it effectively.
In an arena such as health care, where privacy concerns are paramount, and data collection is both disperse and diverse, it is not surprising that the challenges of using big data have – until recently – appeared to outweigh the benefits. However, as other industries [...]
The research laboratory of Mayo Clinic pediatric oncologist Richard J. Bram, M.D., Ph.D., was enjoying the kind of success many researchers hope for. His team in Rochester, Minnesota, had long been interested in studying brain tumors, particularly those in children.
“They’re the second most common malignancy in children, but the development of cures has lagged,” Dr. Bram says.
Dr. Bram’s research team made a big discovery: They found that a particular protein called cyclophilin B turned up in abundance in glioblastomas and medulloblastomas, two deadly nervous system tumors.
The protein seemed to be critical to these two cancers. “The findings suggested the protein could be a good target for a drug, selectively [...]
Summer Undergraduate Research Fellowships are awarded every year to deserving students who are interested in exploring specific topics in research. The goal, in addition to learning alongside professional medical researchers, is to determine if the students are truly interested in persuing research as a career. The students do everything a scientist does, including presenting findings at the end of their project. Mayo Clinic's bumper crop of nuSURF students (nu for nephrology and urology) did rather well this year, according to mentor Michael Romero, Ph.D. Vanderbilt University in Nashville was the destination for Mayo's 23 SURF fellows, where they attended a two-day conference for [...]
Four researchers at Mayo Clinic combined their talents to spur a “bedside to bench” movement that takes the issues they face in the clinic back to the laboratory in the hopes of discovering biomarkers to help specific patients facing difficult medical problems.
George Vasmatzis, Ph.D., co-director of Mayo Clinic’s Biomarker Discovery Program in the Center for Individualized Medicine, has joined thoracic surgeon Dennis Wigle, M.D., Ph.D., urologist R. Jeffrey Karnes, M.D., and hematopathologist Andrew L. Feldman, M.D., in harnessing the power of biomarkers to benefit their patients. This new approach to discovering medical biomarkers has led to 32 molecular cancer discoveries in 2013 alone and dozens of tests that physicians [...]
Editor’s note: The following post is by Susannah Tye, Ph.D., researcher in Mayo’s Department of Psychiatry and Psychology. She and her team will be presenting at the Society for Neuroscience meeting in Washington, D.C. next week.
An important issue in the treatment of depression is development of new and effective treatments for those patients that do not respond effectively to available antidepressant therapies. Such individuals are diagnosed with treatment resistant depression. Without effective treatment, these individuals can suffer for months or years limited or no relief from their symptoms. Researchers within the Mayo Clinic Depression Center are investigating the reasons why some patients do [...]
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