Advancing The Science

Mayo Clinic Medical Science Blog

April 16th, 2014 · Leave a Comment

The Road to Discovery Runs through Mayo’s Clinical Research Unit

By Bob Nellis


The road to developments that change medicine is jammed with great ideas.  It meanders like a mountain trail in the early stages with many ideas failing and being discarded.  But once an innovative medical breakthrough reaches the point of clinic research, the road runs straight as a Midwest highway through a patient-study unit nestled in Mayo Clinic’s campus in Rochester, Minn.

The Clinical Research Unit (CRU) is the unsung waypoint through which any number of landmark patient studies have traveled en route to improving the lives of millions of people, including revolutionary discoveries in osteoporosis, gastrointestinal distress, sleep apnea and cardiovascular disease, and diseases related to physiology.  Here is a look at one [...]

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April 7th, 2014 · Leave a Comment

Cancer Researchers Begin Blog Series on Cures for Kidney Cancer

By Bob Nellis


Tan MD Winston W 08-10

Winston Tan, M.D.


John Copland, III, Ph.D.


We’re Drs. Winston Tan and John “Al” Copland and we collaborate in pursuit of cures for kidney cancer.  Winston is a Mayo Clinic physician oncologist who treats kidney cancer patients and collaborates with Al, a Mayo scientist dedicated to kidney cancer research.

In talking with kidney cancer survivors and friends, we have been encouraged to begin a blog about our research efforts and discoveries in kidney cancer. Current FDA approved drugs are not cures.  They provide some survival benefit (in a small [...]

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Tags: kidney cancer, Mayo Clinic Cancer Center, Mayo Clinic research, SCD1, Winston Tan, Al Copland

April 3rd, 2014 · Leave a Comment

Volunteers Sought: People with HPV-positive Tonsil and Tongue Cancers

By Nicole Brudos Ferrara

Mayo Clinic in Rochester, Minn., is seeking volunteers for a clinical trial for patients with human papillomavirus (HPV) positive tonsil or tongue (oropharynx) cancer whose disease has not spread outside of the neck. The purpose of the study is to find out if reducing treatment time and dosage can control the cancer while decreasing short-term and long-term side effects associated with treatment.

Who is eligible?
You may be eligible to participate in this study if you:

  • Have been diagnosed with HPV-positive tonsil or tongue (oropharynx) cancer.
  • Are 18 years of age or older.
  • Have never, or have almost never, smoked. (For medical professionals: Less than a 10 pack-year smoking history or less than a [...]

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Tags: cancer, clinical trial, Daniel Ma, head and neck cancer, HPV, tongue cancer, tonsil cancer, trial, volunteer

March 27th, 2014 · Leave a Comment

Gregory Gores, M.D., Receives 2014 AGA Distinguished Mentor Award

By Gina Chiri-Osmond

Gregory Gores 2014 WP

Congratulations to Gregory Gores, M.D., who recently received the 2014 American Gastroenterological Association (AGA) Distinguished Mentor Award. Dr. Gores is the current Executive Dean for Research at Mayo Clinic in Rochester, Minn., responsible for the leadership and management of all Mayo research centers, divisions, programs, and other research activity. In assuming this role, Dr. Gores is recognized with the distinction of a named professorship: the Mr. and Mrs. Ronald F. Kinney Executive Dean for Research Honoring Ronald F. Kinney, Jr.

The American Gastroenterological Association is the trusted voice of the GI community. Founded in 1897, the AGA has grown to include more than 16,000 members from around the globe who are involved [...]

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Tags: AGA, award, Distinguished Mentor Award, Executive Dean for Research, Gastroenterology, GI, Greg Gores, MD, mentor, people, research, research awards

February 28th, 2014 · Leave a Comment

The Connection Between Teeth and Heart Surgery

By Bob Nellis

We want to pass on some published Mayo Clinic research as reflected in the media this week. This one, from the Annals of Thoracic Surgery is especially interesting and useful to both physicians and patients alike.

HealthDayGetting Teeth Pulled Before Heart Surgery May Pose Serious Risks by Randy Dotinga…In a small, retrospective study, Mayo Clinic researchers found that 8 percent of heart patients who did not wait to have teeth pulled suffered major adverse health outcomes, such as a heart attack, stroke, kidney failure or death. "Guidelines from the American College of Cardiology and American Heart Association label dental extraction as a minor procedure, with the risk of death or non-fatal heart attack estimated to be less than 1 percent," study co-author Dr. Mark Smith [...]

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Tags: Annals of Thoracic Surgery, cardiology, heart disease, heart surgery, teeth, thoracic reearch

January 2nd, 2014 · Leave a Comment

Reversing Breast Cancer With Injectable Nanoparticles

By Admin

A Mayo Clinic researcher, along with collaborators from Harvard Medical School, developed a method to first identify a breast-cancer-promoting gene and then specifically target this gene with a nanoparticle-based, injectable therapy that reverses breast cancer in mice.  The results, published this week in Science Translational Medicine, may provide a first step in developing a new non-surgical treatment option for patients diagnosed with early-stage breast cancer.   

Milk ducts in cancer-prone mice are packed with tumor cells (deep purple cells, shown by arrow), causing the ducts to grow fatter. But milk ducts in mice treated with a gene-silencing nanoparticle remain mostly hollow (right, shown by arrows), like healthy ducts. Credit: Amy Brock

“Precancerous [...]

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Tags: breast cancer, Harvard, HoxA1, Mayo Clinic, Nanoparticles

December 18th, 2013 · Leave a Comment

Luring Cancer: Custom “Bait” Catches Recurrent Prostate Cancer

By Admin

From Mayo Clinic's Discovery's Edge magazine


Many prostate cancer survivors live in fear of being told that their cancer has returned. It’s even scarier to be told that the doctor knows the cancer is there because of rising PSA levels, but that he can’t find it. Doctors and patients alike know that early detection of the recurrent cancer is critical to the patient’s chance of beating it a second time.

The problem, however, is locating it.

A Mayo Clinic research team has developed a new imaging technique that can often find the recurrent disease months, if not years, earlier than other imaging techniques. Prostate cancer uses choline, a B-complex vitamin, as [...]

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Tags: cancer imaging, choline C-11, Mayo Clinic Cancer Center, PET scan, prostate cancer, Radiation Oncology

December 16th, 2013 · Leave a Comment

Mayo Clinic’s Week at #WSCS13 in San Diego

By Jason Pratt

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Tags: World Stem Cell Summit, WSCS13

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