Advancing the Science

Mayo Clinic Medical Science Blog – an eclectic collection of research- and research education-related stories: feature stories, mini news bites, learning opportunities, profiles and more from Mayo Clinic.

Mar 2, 2021

Mayo Clinic algorithm shows potential in individualizing treatment for depression

By Susan Murphy @susanmurphy
Finding an effective antidepressant medication for people diagnosed with depression, also called major depressive disorder, is often a long and complex process of "try and try again" ― going from one prescription to the next until achieving a therapeutic response. This complex disease, which affects more than 16 million people in the U.S., [...]
Mayo Clinic algorithm shows potential in individualizing treatment for depression
Mar 1, 2021

Mayo Clinic Research in the news -- 3/1/2021

By Elizabeth Zimmermann @elizabethzimmermann
Media coverage of Mayo Clinic research and expertise covered home cancer screening tests, youth vaping, several advancements in women's health, COVID-19 and many other topics. Read on for excerpts and links to the articles. Health officials: "Youth vaping a serious issue"  KAAL, 2/25/2021 New findings show youth vaping in Minnesota is worse than [...]
Mayo Clinic Research in the news -- 3/1/2021
Feb 24, 2021

Regenerative Medicine Minnesota awards 7 research grants to Mayo investigators

By Susan Buckles @susanbuckles
Regenerative Medicine Minnesota, a statewide bipartisan initiative, has awarded seven research grants to Mayo Clinic to advance research and practice in the emerging field of regenerative sciences. Established by Minnesota lawmakers, Regenerative Medicine Minnesota seeks to provide new health care options by advancing regenerative medicine into patient care across the state. [...]
Regenerative Medicine Minnesota awards 7 research grants to Mayo investigators
Feb 22, 2021

Mayo Clinic Research in the news -- 2/22/2021

By Elizabeth Zimmermann @elizabethzimmermann
Over the last week, Mayo Clinic researchers and expertise have been cited in wide range of news stories, from the ever present COVID-19 to telehealth, participation in cancer clinical trials, creatine supplements, artificial intelligence and more. Read on for headlines, excerpts and links. Telehealth research & key resources: Research findings American Medical [...]
Mayo Clinic Research in the news -- 2/22/2021
Feb 18, 2021

Advances in sports medicine emerging from Mayo Clinic Health System and collaborators

By Elizabeth Zimmermann @elizabethzimmermann
The year 2020 offered more research challenges than normal. Many researchers shifted their focus almost entirely to SARS-CoV-2 and COVID-19 – looking for ways to detect, treat and prevent infection, while some projects were forced to take a backseat until conditions improved. Others found the time they needed to move [...]
Advances in sports medicine emerging from Mayo Clinic Health System and collaborators
Feb 17, 2021

Advancing cell-based regenerative therapy for heart failure

By Susan Buckles @susanbuckles
February is American Heart Month, a time to highlight innovative research that seeks to advance cellular therapy as a new option for restoring heart health. One of the latest discoveries in the Center for Regenerative Medicine and Mayo Clinic Van Cleve Cardiac Regenerative Medicine Program established a way to engineer [...]
Advancing cell-based regenerative therapy for heart failure
Feb 16, 2021

Mayo Clinic Research in the news -- 2/15/2021

By Advancing the Science contributor @advancingthescience
Mayo Clinic research and faculty were highlighted in a range of articles over the last week. Headlines and links below to stories on research collaborations and expansions, as well as specific disease advancements, and all the latest COVID-19 news and information.  Ionic liquid formulation can uniformly deliver chemotherapy to tumors while [...]
Mayo Clinic Research in the news -- 2/15/2021
Feb 16, 2021

First hybrid gene therapy shows early promise in treating long QT syndrome

By Colette Gallagher @colettegallagher
In a new study published in Circulation, Mayo Clinic researchers provide the first preclinical, proof-of-concept study for hybrid gene therapy in long QT syndrome, a potentially lethal heart rhythm condition. Researchers demonstrated its potential therapeutic efficacy in two in vitro model systems using beating heart cells reengineered from the blood samples of patients [...]
First hybrid gene therapy shows early promise in treating long QT syndrome
Feb 12, 2021

Body fat investigation provides insights for 'obesity paradox'

By Elizabeth Zimmermann @elizabethzimmermann
The Obesity Paradox Excerpted from a 2009 Mayo Clinic Proceedings article, The Obesity Paradox: Perception vs Knowledge. "Data from several epidemiological studies, including the Framingham Heart Study, have found a positive relationship between obesity and mortality, in particular cardiovascular mortality. However, several cross-sectional, retrospective database studies … have found an inverse correlation [...]
Body fat investigation provides insights for 'obesity paradox'
Feb 11, 2021

Mayo researchers explore genetics behind COVID-19 outcomes

By Susan Murphy @susanmurphy
Some patients with COVID-19 experience severe complications, such as organ damage, shortness of breath, neurological impairment and chronic fatigue. A team of researchers within Mayo Clinic Center for Individualized Medicine is contributing to the global effort of using advanced genetic sequencing to find out which genes influence disease outcomes. “Our findings will be [...]
Mayo researchers explore genetics behind COVID-19 outcomes
Feb 10, 2021

Researchers define best practices of genome sequencing for patients with rare diseases

By Colette Gallagher @colettegallagher
Genome sequencing has shown promise in becoming a first-tier diagnostic test for patients with rare genetic disorders, but standards addressing the definition and deployment of a best-in-class test are lacking. Two recent manuscripts published in npj Genomic Medicine present consensus recommendations on clinical genome sequencing analytical validation and clinical utility to diagnose patients with suspected genetic diseases, [...]
Researchers define best practices of genome sequencing for patients with rare diseases
Feb 9, 2021

New surgery offers hope for heart failure patient

By Advancing the Science contributor @advancingthescience
Cynthia Chauhan works in her sprawling flower garden in Wichita, Kansas, on a summer day, when she notices a vibrant monarch butterfly fluttering near the milkweed. Cynthia realizes only after snapping a photo that the butterfly has a broken wing. “When he’s busy doing his butterfly thing and you’re observing, you [...]
New surgery offers hope for heart failure patient
Feb 8, 2021

Mayo Clinic Research in the news -- 2/8/2021

By Elizabeth Zimmermann @elizabethzimmermann
In the week's news, you can find expertise from Mayo Clinic clinicians and researchers on a range of topics, including several different heart conditions, a blood test for Alzheimer's, cancer, disparities in diabetes care, and of course COVID-19. Expertise from a Mayo Clinic International consultant is also highlighted, along with [...]
Mayo Clinic Research in the news -- 2/8/2021
Feb 5, 2021

Tapping regenerative sciences to unlock mysteries of peripheral neuropathy

By Susan Buckles @susanbuckles
Mayo Clinic is using regenerative sciences to unravel the mysteries of peripheral neuropathy and deliver new cures for a painful disease that affects millions of Americans. Nathan Staff, M.D., Ph.D., a Mayo Clinic neurologist, is leveraging stem cells to recreate neuropathy in a petri dish to trace the origins of a [...]
Tapping regenerative sciences to unlock mysteries of peripheral neuropathy
Feb 4, 2021

Dr. Ikezu pushes to find answers for Alzheimer's disease

By Advancing the Science contributor @advancingthescience
Tsuneya Ikezu, M.D., Ph.D., is a Mayo Clinic molecular neuroscientist who originally hails from Japan. Dr. Ikezu's science career has led him across the globe to work at Mayo Clinic in Florida. His lab will be located temporarily in the Griffin Building. His research focuses on Alzheimer's disease and related [...]
Dr. Ikezu pushes to find answers for Alzheimer's disease
Feb 3, 2021

Diabetes Powerfully Associated with Premature Coronary Heart Disease in Women

By Advancing the Science contributor @advancingthescience
A new biomarker of insulin resistance was tied to a 600 percent increase in risk of premature coronary heart disease By Brigham and Women's Hospital Press Office BOSTON — While deaths related to heart disease have declined among older people, studies suggest that death rates among younger patients have remained stagnant or [...]
Diabetes Powerfully Associated with Premature Coronary Heart Disease in Women
Feb 2, 2021

Diabetes treatment disparities widespread, room for improvement

By Elizabeth Zimmermann @elizabethzimmermann
More than 34 million people in the U.S. have diabetes, reports the Centers for Disease Control and Prevention.Of these, the vast majority have type 2, or a reduced ability of their bodies to effectively process sugar in foods into energy for life. Most people with type 2 diabetes have multiple considerations [...]
Diabetes treatment disparities widespread, room for improvement
Feb 1, 2021

Mayo Clinic Research in the news -- 2/1/2021

By Elizabeth Zimmermann @elizabethzimmermann
Mayo Clinic faculty continue to share their expertise across a broad range of medical and health care topics, including women's health, concussion, disparities in care, and the never abating COVID-19. Mayo Clinic Indicates Age Has Distinct Influences on Sex-Related Outcomes After Heart Attack Pharmacy Times, 1/27/2021 Researchers at the Mayo Clinic have found [...]
Mayo Clinic Research in the news -- 2/1/2021
Jan 29, 2021

IMPACT Bootcamp: Navigating the Journey from Digital Health Technologies to Meaningful Patient Outcomes

By Advancing the Science contributor @advancingthescience
Are you a digital health innovator? Are you building sensors, wearables, or other digital health tools to be used in clinical trials to capture information about how patients feel, function, or survive? Join the U.S. Food and Drug Administration, the Yale University and Mayo Clinic CERSI and the Yale School of Medicine Center for [...]
IMPACT Bootcamp: Navigating the Journey from Digital Health Technologies to Meaningful Patient Outcomes
Jan 28, 2021

Regenerating the larynx: A second chance at speech

By Susan Buckles @susanbuckles
Mayo Clinic is leveraging advances in regenerative medicine to restore function for people whose lives have been drastically changed by a laryngectomy — surgery to remove the voice box. People without a voice box can neither speak with their natural voices nor breathe through their noses. Simple pleasures like smelling [...]
Regenerating the larynx: A second chance at speech
Jan 27, 2021

Mitochondria vs. Alzheimer's

By Advancing the Science contributor @advancingthescience
Targeting mitochondria is a promising therapeutic strategy, study shows "Mitochondria are the powerhouses of the cell." Many a young science student has heard that truism. "Mitochondria are extremely important because they ensure that we have energy supply for cells to conduct functions," says Mayo Clinic researcher Eugenia Trushina, Ph.D. "Otherwise, we would [...]
Mitochondria vs. Alzheimer's
Jan 25, 2021

Mayo Clinic Research in the news -- 1/25/2021

By Elizabeth Zimmermann @elizabethzimmermann
From acupuncture, breast cancer, diabetes, euthyroid ... all the way to Zika, Mayo Clinic research and experts are featured in the news. Also find COVID-19 observations, advice and findings. The Rochester Epidemiology Project: “The greatest medical resource you’ve never heard of” Rochester Magazine, 1/22/2021 The Rochester Epidemiology Project has changed the way we [...]
Mayo Clinic Research in the news -- 1/25/2021
Jan 21, 2021

Pioneering living donor cartilage transplants

By Susan Buckles @susanbuckles
Mayo Clinic is poised to establish what is believed to be the first-ever living cartilage donor bank to provide a new regenerative option for healing common knee injuries. That donor bank will lay the foundation for living donor musculoskeletal tissue transplants — a first at Mayo Clinic and possibly in [...]
Pioneering living donor cartilage transplants
Jan 20, 2021

PET/MRI biomarkers guide personalized treatment for patients with pancreatic cancer, study finds

By Advancing the Science contributor @advancingthescience
By Ethan Grove Positron emission tomography (PET)/MRI has changed how Mayo Clinic specialists treat patients with pancreatic cancer. Mayo Clinic pioneered the use of PET/MRI to manage pancreatic cancer. Now a new study by Ananya Panda, M.B.B.S. (@AnanyaPanda15), and colleagues systematically evaluates the strengths of PET/MRI for pancreatic ductal adenocarcinoma. In less than [...]
PET/MRI biomarkers guide personalized treatment for patients with pancreatic cancer, study finds
Jan 19, 2021

Rare esophageal cancer hits younger patients especially hard

By Caitlin Doran @caityrosey
Esophageal cancer is relatively rare, making up only about 1% of cancer cases diagnosed each year in the U.S. Mayo Clinic researchers have found that esophageal adenocarcinoma, a type of esophageal cancer, has been rising in incidence over the past 40 years, particularly among people under 50. More concerning is [...]
Rare esophageal cancer hits younger patients especially hard
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