Advancing the Science

Mayo Clinic Medical Science Blog – an eclectic collection of research- and research education-related stories: feature stories, mini news bites, learning opportunities, profiles and more from Mayo Clinic.

Dec 2, 2020

Conquering cancer by targeting its genetic abnormalities

By Susan Murphy @susanmurphy
Joanne Garnett has harrowing memories of that life-changing day back in 1981. She was a 39-year-old land use planner living in Wyoming when she received a call from her doctor confirming she had uterine cancer.  “I was shocked, and it was strange because I didn’t fit any profile for uterine cancer,” Garnett [...]
Conquering cancer by targeting its genetic abnormalities
Dec 1, 2020

Could regenerative medicine provide a new approach to diabetes care?

By Susan Buckles @susanbuckles
November is National Diabetes Month, a time to reflect on new ways to manage a chronic condition that affects young and old. Mayo Clinic is applying a regenerative lens to advancing diabetes care beyond routine blood checks and standard insulin therapy. Quinn Peterson, Ph.D.; Aleksey Matveyenko, Ph.D.; and Alexander Revzin, Ph.D., [...]
Could regenerative medicine provide a new approach to diabetes care?
Nov 30, 2020

Mayo Clinic Research in the news -- 11/30/2020

By Elizabeth Zimmermann @elizabethzimmermann
Many of you may feel like it's been a really long time since the last update, but in reality, it's been 7 days. Thanksgiving in 2020 and the fretting related to the holiday – amplified 100-fold by COVID-19 – may have made this past week seem unusually long. But at [...]
Mayo Clinic Research in the news -- 11/30/2020
Nov 24, 2020

3D brain models advance Alzheimer's disease research at Mayo Clinic

By Susan Buckles @susanbuckles
A 3D model of brain organoids — "a minibrain in a dish" — mimics human brain structure and provides a new scientific strategy for exploring the pathology of Alzheimer's disease, Mayo Clinic research discovered. The study, which was published in Nature Communications, finds that the minibrain — an induced pluripotent [...]
3D brain models advance Alzheimer's disease research at Mayo Clinic
Nov 23, 2020

Mayo Clinic Research in the news -- 11/23/2020

By Elizabeth Zimmermann @elizabethzimmermann
There were all sorts of different things in the news this week, but perhaps the most heartening was the news from Dr. Anthony Fauci and our own Gregory Poland, M.D., that Santa Claus and the elves are practicing safe behaviors and COVID-19 won't stop Christmas from arriving.  Read on for [...]
Nov 19, 2020

Breast cancer accurately staged with fewer lymph nodes

By Elizabeth Zimmermann @elizabethzimmermann
When a person is diagnosed with breast cancer, surgery can be their first treatment. Other times, their clinician will prescribe chemotherapy before surgery, called neoadjuvant chemotherapy. In both cases, for patients with clinically negative nodes at presentation, surgeons will determine at the time of surgery how far the cancer has [...]
Breast cancer accurately staged with fewer lymph nodes
Nov 18, 2020

Mayo Clinic study finds 1 in 8 patients with cancer harbor inherited genetic mutations

By Susan Murphy @susanmurphy
Genetic testing can uncover inherited genetic mutations, and could individualize cancer therapies, improve survival, manage cancer in loved ones and push the boundaries of precision medicine. In a new study published in JAMA Oncology, scientists with Mayo Clinic's Center for Individualized Medicine conducted genetic testing in more than 3,000 patients who were diagnosed with cancer [...]
Mayo Clinic study finds 1 in 8 patients with cancer harbor inherited genetic mutations
Nov 17, 2020

Early-stage clinical trial provides hope for patients with traumatic spinal cord injuries

By Advancing the Science contributor @advancingthescience
Early research at Mayo Clinic is a step toward hope for a future treatment for patients with traumatic spinal cord injury. The research in this article discusses the experience related to the first case in a phase I safety study of mesenchymal stem cell treatment for spinal cord injury. The case [...]
Early-stage clinical trial provides hope for patients with traumatic spinal cord injuries
Nov 16, 2020

Mayo Clinic Research in the news -- 11/16/2020

By Elizabeth Zimmermann @elizabethzimmermann
Our research and researchers showed up in a wide range of news stories over the last week, including potential benefits of coffee for patients with colorectal cancer, plus other related stories on racial disparities in screening, and recurrence of polyps. There is COVID-19 news you can use related to obesity, [...]
Mayo Clinic Research in the news -- 11/16/2020
Nov 12, 2020

New research shows markers in donor kidneys that could reduce risks

By Advancing the Science contributor @advancingthescience
By Jay Furst The donation of a kidney to a person in need of a transplant is one of the most profound gifts a person can offer. The process for living kidney donors is safe, and, at Mayo Clinic, which has one of the largest living-donor kidney transplant programs in the [...]
New research shows markers in donor kidneys that could reduce risks
Nov 10, 2020

Advancing neuroscience at Mayo Clinic in Florida: Dr. Sandro Da Mesquita

By Advancing the Science contributor @advancingthescience
What is your background? I am a biochemist by training and performed all of my graduate studies in Portugal, at the School of Medicine of the University of Minho, located in a northern Portuguese city called Braga. It was in grad school that I started to develop a particular taste for [...]
Advancing neuroscience at Mayo Clinic in Florida: Dr. Sandro Da Mesquita
Nov 9, 2020

Mayo Clinic Research in the news -- 11/9/2020

By Elizabeth Zimmermann @elizabethzimmermann
As SARS-CoV-2 spreads throughout the world, COVID-19 has become the subject of almost every conversation. Not surprisingly, the media are actively following developments in research on symptoms, testing, treatment and vaccines. In addition to some of these stories, you'll find Mayo Clinic research and researchers highlighted across a wide range [...]
Mayo Clinic Research in the news -- 11/9/2020
Nov 6, 2020

Long-term safety, benefits of stem cell therapy for heart failure

By Susan Buckles @susanbuckles
The largest regenerative medicine clinical trial to date for heart failure finds stem cell therapy is safe over the long term and benefits patients with advanced left ventricular enlargement. This multinational research, co-led by Andre Terzic, M.D., Ph.D., director of Mayo Clinic's Center for Regenerative Medicine, and published in ESC [...]
Long-term safety, benefits of stem cell therapy for heart failure
Nov 5, 2020

Faced with a pandemic, undergraduate research programs innovate and evolve

By Caitlin Doran @caityrosey
This summer, COVID-19 nearly sidetracked research training plans for more than 200 students who had been accepted in to Mayo’s competitive undergraduate programs—Summer Undergraduate Research Fellowship (SURF) and Undergraduate Research Experience Program (UREP).  However, instead of cancelling the programs, the Mayo Clinic Graduate School of Biomedical Sciences decided to innovate [...]
Faced with a pandemic, undergraduate research programs innovate and evolve
Nov 3, 2020

COVID-19 and influenza testing algorithm arms Mayo Clinic for the upcoming flu season

By Advancing the Science contributor @advancingthescience
By Christoph Bahn Flu season is just now unfolding. But this time, it’s piggy-backed with a pandemic, which threatens to spike with the colder weather as people huddle indoors. Adding to this conundrum is the unsettling fact that, for both COVID-19 and the flu, the symptoms overlap. “It’s almost impossible to distinguish [...]
COVID-19 and influenza testing algorithm arms Mayo Clinic for the upcoming flu season
Nov 2, 2020

Mayo Clinic Research in the news -- 11/2/2020

By Elizabeth Zimmermann @elizabethzimmermann
If you spend any time reading or listening to health care news, you know that some of the same stories are still making their way around the world as last week or even from several weeks back. You may see some repeats from a different news outlet here, but we [...]
Mayo Clinic Research in the news -- 11/2/2020
Oct 29, 2020

Developing solutions for early detection of pancreatic cancer

By Advancing the Science contributor @advancingthescience
By Lisa Newkirk Pancreatic cancer is one of the deadliest forms of cancer, but patients who are diagnosed at an early stage can survive five years or longer. A team at Mayo Clinic is developing patient-centered solutions for early detection of pancreatic cancer using artificial intelligence and biomarkers. This year, over 57,000 Americans [...]
Developing solutions for early detection of pancreatic cancer
Oct 28, 2020

Stem cell therapy to repair kidney damager

By Susan Buckles @susanbuckles
Mesenchymal stem cells derived from a person's fat cells may help repair kidney damage caused by narrowing blood vessels, Mayo Clinic research has discovered. The research by Stephen Textor, M.D., and his team is published in Kidney International. Mayo Clinic Center for Regenerative Medicine and the National Institutes of Health supported [...]
Stem cell therapy to repair kidney damager
Oct 27, 2020

Researchers find joy in their work and each other

By Advancing the Science contributor @advancingthescience
Sometimes satisfaction must be found in the day-to-day steps while continuing the work of finding a breakthrough. For Eva Morava-Kozicz, M.D., Ph.D., the process of developing therapies for new metabolic disorders is a fight won by inches, against an opponent that does not fight fair. Dr. Morava-Kozicz’s latest work concerns genetic conditions [...]
Researchers find joy in their work and each other
Oct 26, 2020

Mayo Clinic Research in the news -- 10/26/2020

By Elizabeth Zimmermann @elizabethzimmermann
At Mayo Clinic, patient care is evidence-based, meaning research drives the practice of medicine. Our scientists and clinician researchers are at work across the spectrum of health and the delivery of health care, seeking better outcomes and enhanced experiences while managing the total costs of care. Curable dementia, pot and [...]
Mayo Clinic Research in the news -- 10/26/2020
Oct 23, 2020

Examining and mitigating musculoskeletal strains experienced by medical professionals

By Advancing the Science contributor @advancingthescience
By Nick Fetty, Iowa State University College of Engineering Surgeons and other medical professionals can develop musculoskeletal problems because of the excessive amount of time they spend on their feet and the awkward postures that they assume during their work tasks. Researchers in Iowa State University’s Department of Industrial and Manufacturing Systems [...]
Examining and mitigating musculoskeletal strains experienced by medical professionals
Oct 21, 2020

Early data on managing COVID-19 in pregnancy

By Advancing the Science contributor @advancingthescience
By Jay Furst The COVID-19 pandemic has added a new and hard-to-answer concern for pregnant women: Does COVID-19 pose greater risks for the mother during pregnancy? Kavita Narang, M.D., a fellow in the Mayo Clinic Division of Maternal and Fetal Medicine, recently co-authored a review in Mayo Clinic Proceedings on COVID-19 and [...]
Early data on managing COVID-19 in pregnancy
Oct 20, 2020

Delivering innovative stem cell therapy to slow vision loss

By Susan Buckles @susanbuckles
The regenerative eye scientist, Alan Marmorstein, Ph.D., is drawn to research by the need to find new cures for diseases. As an aspiring researcher, he never envisioned his investigative journey would take him down the path of testing ways to prevent or restore loss of eyesight. However, a post-doctoral lab [...]
Delivering innovative stem cell therapy to slow vision loss
Oct 19, 2020

Mayo Clinic Research in the news -- 10/19/2020

By Elizabeth Zimmermann @elizabethzimmermann
The news media recently highlighted a range of interesting topics, featuring Mayo Clinic Research and researchers on a new way to hunt down and capture deadly brain cancer cells, MSG in food, Angelman syndrome, the connection between screen time and life expectancy, COVID-19 (of course), and much more. Read on [...]
Mayo Clinic Research in the news -- 10/19/2020
Oct 15, 2020

The latest on testicular cancer-associated KLHL11 encephalitis

By Advancing the Science contributor @advancingthescience
Divyanshu (Div) Dubey, M.B.B.S., a Mayo Clinic physician and researcher, who holds a dual appointment in neurology, and laboratory medicine and pathology, recently led a multi-institutional research study to advance understanding of KLHL11 encephalitis or testicular cancer-associated paraneoplastic encephalitis. Published in JAMA Neurology, the paper builds on the work Dr. Dubey [...]
The latest on testicular cancer-associated KLHL11 encephalitis
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