Advancing the Science

Mayo Clinic Medical Science Blog – an eclectic collection of research- and research education-related stories: feature stories, mini news bites, learning opportunities, profiles and more from Mayo Clinic.

January 5, 2016

Did your patient have cardiac ablation? Don’t stop the anticoagulant!

By Advancing the Science contributor

peter noseworthy

Peter Noseworthy, M.D., is a cardiac electrophysiologist at Mayo Clinic, and a Kern Health Care Delivery Scholar in the Mayo Clinic Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery.


As a cardiac electrophysiologist, I am interested in helping to improve health and quality of life for my patients who see me because of an abnormal heart rhythm. The most common abnormal heart rhythm I treat is atrial fibrillation.

Although quite a few people – some 33 million worldwide – are diagnosed with atrial fibrillation (AF), many live their lives largely unaffected by the condition. AF does increase the risk of stroke, but if they have no other stroke risk factors, that risk is minimal. I, and my colleagues, typically would not recommend cardiac ablation for a patient whose only concern is stroke risk, because the procedure itself carries risks that likely outweigh the benefit in terms of stroke reduction. I tend to think that if a patient is not bothered by other symptoms such as severe palpitations or shortness of breath, why expose them to the risk of a procedure?

Illustration showing cardiac catheter ablation

Cardiac catheter ablation

However, when I do perform a cardiac ablation on one of my patients, it’s imperative that he or she stay on anticoagulants after the procedure – sometimes only for about three months, other times, forever.

My colleagues and I have observed discrepancy in what we believe regarding the appropriate use of anticoagulants post-cardiac ablation, and what is actually being practiced, so we set study the issue further. Our study was published in the Journal of the American Heart Association.

Using the OptumLabs™ Data Warehouse, which provides claims data for over 100 million patients, we were able to examine the records of nearly 7,000 patients who underwent a catheter ablation for atrial fibrillation between 2005 and 2014. We used the Charlson comorbidity index to assess each patient’s overall comorbidity burden.

What we found was somewhat striking. Current guidelines support continuous anticoagulation for 2-3 months post ablation, and indefinitely in high-risk patients. However, 39 percent of patients stopped taking anticoagulants before three months passed and more than half of high risk patients eventually stopped anticoagulation.

Furthermore, we found that 73 patients survived an ischemic stroke, TIA, or systemic embolism after receiving cardiac ablation. More than 53 percent of these events were in patients who had stopped or interrupted anticoagulant use, and nearly 25 percent of these events occurred in the first three months after ablation. Stroke occurred in 1.4 percent of patients with two additional risk factors besides a-fib, and 0.3 percent of those with one or no additional risk factors.

Many of these strokes may have been prevented had the patient stayed on anticoagulants. My colleagues and I hope that this publication and follow-on communication will change the course of events for current and future patients. We hope to see additional education for general internists and cardiologists, as well as patients, so that the best possible decisions can be made regarding anticoagulant use following cardiac ablation.


Tags: About, anticoagulant, atrial fibrillation, cardiology, Center for the Science of Health Care Delivery, Findings, OptumLabs, Peter Noseworthy, Progress Updates, stroke

Very interesting! Good information from the best doctor I’ve ever come in contact with!


Very interesting! Good information from the best doctor I’ve ever come in contact with!

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@Velda47, thank you for your kind comment, and thank you for reading Advancing The Science!

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