10,000 people help answer a basic individualized medicine question
Nearly 1 out of every 3 American adults has high blood pressure. About 70 percent of them take medication for their condition, but only half have it under control. Why? The answer gets to the heart of individualized medicine: Because each person has a unique genetic makeup, everyone responds differently to drugs.
In recent years, individualized medicine, sometimes called precision medicine, has made headlines by predicting the possibility an individual may develop a specific disease — think BRCA1 and BRCA2 genetic mutations linked to breast and ovarian cancers.
But that is just the tip of the genomic iceberg, says Richard Weinshilboum, M.D., director of the Mayo Clinic Center for Individualized Medicine's Pharmacogenomics Program and the Mary Lou and John H. Dasburg Professor of Cancer Genomics.
Mayo Clinic is gathering this knowledge for 10,000 people, seeking to understand their individual makeup, and provide uniquely personalized care—with an eye toward improving health care delivery for everyone.
Known as the RIGHT Protocol (short for the Right Drug, Right Dose, Right Time: Using Genomic Data to Individualize Treatment), the study pre-emptively embeds a patient's genetic information in the electronic health record for future use to see if doing so improves long-term outcomes for both the patient and the health care delivery system at large. This project is a collaboration across several groups, including: