Advancing the Science

Mayo Clinic Medical Science Blog – an eclectic collection of research- and research education-related stories: feature stories, mini news bites, learning opportunities, profiles and more from Mayo Clinic.

November 7, 2017

No moss here – Mayo Clinic research websites rolling along

By Elizabeth Zimmermann

They say that a rolling stone gathers no moss, and at Mayo Clinic, our research and research education programs are always on the move. It's hard to keep track of all the exciting work being done to help improve health for our patients, or the way they - and patients everywhere - experience health care. But checking out these websites, with the newest research content we have available, is one way to learn more. Thanks for visiting!

Led by Dev Mukhopadhyay, Ph.D., the Translational Nanomedicine Program, based on the Florida campus of Mayo Clinic, conducts basic science research to synthesize and create detailed characterizations of novel nanomaterials.

A precise understanding of the chemical and physical properties of nanomaterials paves the path for clinician-investigators to explore the uses of these materials in translational nanomedicine applied to patient care.

Read more about the program's beginning.

Within the Department of Molecular Medicine, a multidisciplinary team of scientists and physicians are building a premier virus, gene and cell therapy program and working to translate promising therapeutics from bench to bedside in a timely manner.

Led by Evanthia Galanis, M.D., the department provides core facilities and services to support research efforts across the entire discovery-translation-application spectrum. Basic science discoveries in virology, cell biology, genomics and immunology lead to testing of these novel concepts in clinical trials, such as trials using modified viruses to kill tumors (oncolytic virus therapy).

In this research image, muscle cells fluoresce green after gene transfer.

In his lab, Christopher H. Evans, Ph.D., and his team are hoping that new genes may be the answer to osteoarthritis.

Among other projects, they are studying the use of a viral vector to introduce an anti-arthritic gene into the knee joints of patients with osteoarthritis. They also are investigating ways to help bones, tendons and cartilage heal.

By studying the biochemistry of life, Louis (Jim) J. Maher III, Ph.D., and his team hope to learn more about how the actual shapes of DNA and RNA influence gene expression. Further, they  want to find ways to use RNA and DNA in new medications, and how errors in DNA cause cancer.

RNA aptamers binding NF-kappaB transcription factor.

Projects include:

  • DNA flexibility in cells
  • Artificial gene regulation by RNA molecules
  • Aptamers in multiple sclerosis research
  • Biochemistry of human parganglioma

Watch a TEDx talk and other videos from Dr. Maher describing some of this research.

Overhead photo of face transplant team.

As a global leader in transplantation, Mayo Clinic performs an unparalleled number of solid organ transplants and blood and bone marrow transplants.

Led by Michael J. Krowka, M.D., in the Transplant Research Center, programs leverage the unique integrated practice, research and education programs of Mayo Clinic to conduct interdisciplinary research in solid organ transplantation, blood and bone marrow transplantation, and reconstructive transplantation.

In addition to seeking ways to improve outcomes and the overall patient experience for people needing transplants, some research in the center also focuses on finding alternative therapies for people who may not need a transplant.

Mayo Clinic Transplant Research Center activities also encompass state-of-the-art clinical transplant programs and graduate medical education opportunities.


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Tags: About, basic science, Christopher Evans, Dev Mukhopadhyay, DNA, Eva Galanis, gene therapy, Innovations, Jim Maher, Michael Krowka, nanomedicine, osteoarthritis, transplant

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