Advancing the Science

Mayo Clinic Medical Science Blog – an eclectic collection of research- and research education-related stories: feature stories, mini news bites, learning opportunities, profiles and more from Mayo Clinic.

April 23, 2020

Antimalarials, COVID-19, cardiac arrest

By Elizabeth Zimmermann
3-D model of COVID-19 virus

Over the last few weeks, chloroquine and hydroxychloroquine have become household words. These antiparasitic drugs normally prescribed for malaria were introduced early in the rush to find potential treatments for COVID-19. As time goes on, the public discussion has centered on who should get these particular drugs and when. Meanwhile many doctors and medical researchers are asking a different question: if COVID-19 patients should receive these drugs at all.

Off-label use of medication is not unusual, especially in the case of a new disease or virus like Sars-CoV-2. Physicians and researchers will dig into their toolbox and try all sorts of treatments - both old and new - in hopes that something will help patients.

In a new article from Science, reporter Kelly Servick explores hydroxychloroquine and chloroquine, and their intersections with COVID-19. She talks with Michael Ackerman, M.D., a genetic cardiologist at Mayo Clinic, who raised concerns in a Mayo Clinic Proceedings article that in the race to find a way to prevent and treat this deadly disease, other deadly side effects might be introduced. In particular, using these drugs to treat COVID-19 could potentially cause arrhythmias and even sudden cardiac death.

For the rest of the story, read Antimalarials widely used against COVID-19 heighten risk of cardiac arrest. How can doctors minimize the danger?

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Tags: basic science, COVID-19, discovery research, Michael Ackerman, News

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