Advancing the Science

Mayo Clinic Medical Science Blog – an eclectic collection of research- and research education-related stories: feature stories, mini news bites, learning opportunities, profiles and more from Mayo Clinic.

October 28, 2020

Stem cell therapy to repair kidney damage

By Susan Buckles

Mesenchymal stem cells derived from a person's fat cells may help repair kidney damage caused by narrowing blood vessels, Mayo Clinic research has discovered. The research by Stephen Textor, M.D., and his team is published in Kidney International.

Mayo Clinic Center for Regenerative Medicine and the National Institutes of Health supported this first-in-human study to determine if stem cells could restore function to a kidney injured by blocked blood vessels. The Center for Regenerative Medicine prioritizes new therapies that can be adopted by the practice.

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Stephen Textor, M.D.

"The surprising discovery was the degree of measurable increase in blood flow despite the main vessel occlusion. The changes in blood flow, oxygenation and function suggest that small vessels are being formed or reopened in the kidney after stem cell therapy," says Dr. Textor.

Atherosclerotic renovascular disease is a hardening and narrowing of arteries that deliver blood to the kidneys. Low blood flow damages tissue, causing chronic kidney disease and eventually end-stage renal failure. Patients then require kidney dialysis. There are limited therapeutic options for reversing kidney damage from vascular disease.

The research

In a phase 1 clinical trial, Dr. Textor's team studied 39 patients with atherosclerotic renovascular disease on two occasions over three months. Researchers infused 21 patients each with mesenchymal stem cells derived from the patient's own fat. Delivered directly into the renal artery of the damaged kidney, the mesenchymal stem cell therapy was given in three different dose amounts. Researchers measured kidney function, oxygen levels, blood flow and markers of injury before the stem cell therapy and three months after infusion. Those data were compared to 18 patients with atherosclerotic renovascular disease treated only with standard therapies.

"The results of this study showed for the first time that cell-based therapy can boost blood flow, increase oxygenation and lower inflammatory injury in this form of kidney injury," says Dr. Textor. "These findings demonstrate the safety of cell-based therapy in the human kidney and identify a dose-related recovery of some kidney function in this disease."

Additional studies will be needed to verify the findings and address whether stem cell therapy could repair common forms of kidney damage, such as damage from diabetes.


This article originally appeared on the Mayo Clinic Center for Regenerative Medicine blog.

Tags: Center for Regenerative Medicine, chronic kidney disease, Findings, mesenchymal stem cells, News, renovascular disease, stem cell therapy, Stephen Textor

I need to find out which facility is doing advanced Stem Cell therapies on Kidneys??
Thank you,
Archie Hyde, 706.255.1921

** Comment posted by subject matter expert **


I need to find out which facility is doing advanced Stem Cell therapies on Kidneys??
Thank you,
Archie Hyde, 706.255.1921

** Comment posted by subject matter expert **

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Hi Archie,
I have not researched kidney disease much but I personally spoke with someone who had regenerative therapy at Rejuv Medical in Minnesota. Dr Bhatengarter? They have 2 facilities in that state. They offer PRP and BMC treatments. IDK if they can help you but they won't take advantage of you. They seem honest. A more advance procedure can be obtained in another country. I have been in contact with Bioxcellerator. They are a U.S. company office in Arizona but facility is in Colombia. Again, i believe, a reputable practice. Also, keep searching the web. New stuff pops up all the time. Our world spins faster these days. Rutgers in New Jersey is quietly trying to get stem cell therapy advances on the table.

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