Advancing the Science

Mayo Clinic Medical Science Blog – an eclectic collection of research- and research education-related stories: feature stories, mini news bites, learning opportunities, profiles and more from Mayo Clinic.

January 11, 2021

Mayo Clinic Research in the news — 1/11/2021

By Elizabeth Zimmermann
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In the news you'll find Mayo Clinic research and faculty cited on a variety of topics including women's health, patient consent, migraine, palliative care and of course COVID-19.

Opinion: Preventing Alzheimer’s in Women Requires a Lifespan Approach

Being patient, 1/8/2021

Carolee Lee of WHAM! (Women’s Health Access Matters) and Michelle M. Mielke at the Specialized Center for Research Excellence on Sex Differences at Mayo Clinic examine the consequences of ignoring gender and biology in Alzheimer’s research — and the pivotal importance of broad lifespan research.

NOTE: More information is also available about Dr. Mielke and the Mayo Clinic Specialized Center of Research Excellence (SCORE) on Sex Differences.

Radiologists assert new data consent agreements are needed before patient trust is gone

Health Imaging, 1/8/2021

Patient health data has become a valuable commodity, helping researchers develop artificial intelligence tools, identify and prevent diseases, and discover novel treatments. The proliferation of such data, however, has made it clear that current patient consent approaches are inadequate.

That’s according to a group of radiologists from top institutions across the U.S., who recently argued that trust between patients and providers is key to truly realizing the power of patient health information. They called on their field to help develop a new patient-centered approach for data consent, in a Jan. 1 opinion piece published in JACR.

“As radiologists, we should acknowledge that we must become more sophisticated about both the technology and business models of sharing imaging data,” Amy L. Kotsenas, MD, chair of clinical digital imaging at the Mayo Clinic’s Department of Radiology, and colleagues wrote. …

NOTE: Read more about Dr. Kotsenas and radiology research at Mayo Clinic.

Chemoimmunotherapy Continues to Display Survival Benefits in Small Cell Lung Cancer

OncLive, 1/7/2021

Yanyan Lou, MD, PhD, highlighted the role of atezolizumab, durvalumab, pembrolizumab, and nivolumab and how they have demonstrated improved survival in combination with etoposide and platinum in untreated extensive-stage small cell lung cancer, cementing checkpoint inhibition plus chemotherapy as a frontline standard.

NOTE: Dr. Lou is vice chair of Research in the Division of Hematology and Oncology at Mayo Clinic in Florida, and associate director of the Early Cancer Therapeutics Program.

Need for Molecular Testing in Lung Cancer Is Underscored as Additional Targets Emerge

OncLive, 1/8/2021

Yujie Zhao, MD, PhD, highlights molecular testing and how it's a critical component of the treatment selection process in lung cancer, as a host of effective drugs have since been developed to target alterations such as ALK, ROS1, and RET.

NOTE: Dr. Zhao is an internist oncologist at Mayo Clinic.

Dr Frank Porreca Talks Through the Challenges of Measuring Migraine Pain

American Journal of Managed Care – podcast, 1/6/2021

Pain is a subjective response with multiple features and components, said Frank Porreca, PhD, professor of pharmacology and anesthesiology at the University of Arizona and a member of the Department of Collaborative Research at Mayo Clinic in Arizona.

NOTE: You can watch the video on the site, or read the transcript of Dr. Porreca's interview.

Inpatient palliative care for PAH low, but use increased in recent years

Healio News, 1/4/2021

Use of palliative care services among inpatients with pulmonary arterial hypertension in the United States increased from 2001 to 2017, with a significant rise in the past decade, researchers reported in Chest.

“Experts recommend incorporation of palliative care services into disease management, but there is little data regarding the utilization of palliative care services among patients with PAH,” Hilary M. DuBrock, MD, from the division of pulmonary and critical care medicine at the Mayo Clinic in Rochester, Minnesota, told Healio. “Our study is important as it provides insight into the current state of palliative care utilization in patients with PAH and also highlights specific disparities that exist regarding use of palliative care services across the country.” …

Young-Onset Esophageal Incidence, Advanced Disease Diagnosis on the Rise

Cancer Network, 1/6/2021

In addition to a concerning trend of increased rates of esophageal adenocarcinoma noted over the last 4 decades, this study also found that the proportion of those with advanced disease at presentation continues to rise for patients younger than age 50.

… “Patients who present with late-stage esophageal cancer typically have poorer outcomes than those with early-stage disease. As such, it is important to understand the epidemiology of esophageal cancer to target our screening strategies,” corresponding author, Prasad G. Iyer, MD, MSc, professor of medicine in the Barrett’s Esophagus Unit in the Division of Gastroenterology and Hepatology at the Mayo Clinic in Rochester, Minnesota, said in a press release.…

Keep the faith

Ahram Online, 1/5/2021

… Researchers at the Mayo Clinic concluded that religious involvement and faith are associated with better health, longevity, coping skills, anxiety, and depression.

Religious people have higher self-esteem and better psychological adjustment. …

NOTE: Read one of the related research papers in Mayo Clinic Proceedings

Manochakian Breaks Down Barriers to Genetic Testing in Lung Cancer

OncLive, 1/4/2021

All patients with advanced lung cancer should undergo genetic testing, both in the tissue and in the blood, to identify targetable mutations, according to Rami Manochakian, MD. Although this is understood to be best practice, several barriers still need to be overcome to ensure this testing is done and the results can be used to inform the optimal approach for each individual patient. …

NOTE: Read Dr. Manochakian's full interview online.

Mayo Clinic weighs in on COVID-19

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Tags: Alzheimer's disease, Amy Kotsenas, artificial intelligence, Barrett's esophagus, COVID-19, data science, esophageal cancer, Findings, Frank Porreca, gene mutation, genetic testing, Hilary DuBrock, lung cancer, Mayo Clinic Proceedings, Michelle Mielke, migraine, molecular testing, News, News of the Week, palliative care, patient experience, patient safety, Prasad Iyer, Progress Updates, pulmonary and critical care medicine, radiology, Rami Manochakian, women's health, Yanyan Lou, Yujie Zhao

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