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Mayo Clinic Medical Science Blog – an eclectic collection of research- and research education-related stories: feature stories, mini news bites, learning opportunities, profiles and more from Mayo Clinic.

January 18, 2021

Mayo Clinic Research in the news — 1/18/2021

By Elizabeth Zimmermann

Mayo Clinic's broad expertise is cited in research findings and commentary regarding midlife exercise benefits, autism markers in birth mothers, health care access, hospital star rating systems, high fiber for depression and several other topics including the ever-present COVID-19.

Oncology Influencers Explain Do’s and Don’t’s of Social Media

OncologyLive, 1/12/2021

… S. Vincent Rajkumar, MD, a 2019 Giants of Cancer Care® award winner in the myeloma category, was an early adopter of Twitter. He signed up in 2009 and currently has more than 31,000 followers.

“I sensed early on that Twitter would be the perfect forum for academic discussion for a larger group of people, many of whom you may not know,” said Rajkumar, who is the Edward W. and Betty Knight Scripps Professor of Medicine and a clinical investigator at Mayo Clinic in Rochester, Minnesota.

NOTE: Learn more about what the experts, including Dr. Rajkumar, have to say about using social media in their professional lives.

Exercise at Midlife Linked to Better Brain Health in Late Life

Medscape, 1/15/2021

Higher levels of leisure-time physical activity in midlife are associated with a lower risk for cerebrovascular problems in later life, an analysis of data from a prospective cohort study suggests.

… "A major strength of the study is the assessment of physical activity in both mid- and late life," said Michelle M. Mielke, PhD, professor of epidemiology and neurology at the Mayo Clinic College of Medicine, Rochester, Minnesota, commenting for Medscape Medical News. "Many previous studies retrospectively collected data on midlife physical activity from those in later life, which is largely affected by recall bias and cognitive status." …

Mothers of children with autism have many significantly different metabolite levels, study finds

News-Medical.Net, 1/17/2021

Autism spectrum disorder (ASD) is a neurological and developmental disorder that starts early in childhood and lasts throughout a person's life. Most commonly, it affects how a person interacts with others, acts, communicates, and learns.

Now, a study by researchers at the Rensselaer Polytechnic Institute, Arizona State University, and the Mayo Clinic found that mothers of children with autism spectrum disorder had several marked different metabolite levels two to five years after they gave birth compared to mothers of normally developing children. …

Eating Habits That Are Shortening Your Life, According to the Mayo Clinic

Eat This, Not That, 1/15/2021

NOTE: This article cites advice from Mayo Clinic experts Katherine Zeratsky, Liza Torborg, Stephen Kopecky, M.D., and refers to a study published in Mayo Clinic Proceedings.

Eli Lilly's Alzheimer's drug shows promise. But will it succeed where so many drugs have failed?

Advisory Board – Daily Briefing, 1/13/2021

Eli Lilly's experimental Alzheimer's disease drug slowed the rate at which participants lost their ability to think and care for themselves, according to a small clinical trial—but experts say there's reason to view the results with caution.

… In addition, some experts noted that observers should view the results with a degree of skepticism because of the trial's size.

Ronald Petersen, who directs the Mayo Clinic Alzheimer's Disease Research Center, said, "These data are fine to rationalize doing the larger study, but these data are too preliminary to conclude any clinical benefit or efficacy." …

FIRST Study to Define Population-Based Incidence of FAI in Large Group of Hip Pain Patients

Ortho Spine News, 1/12/2021

Citing a dearth of data on the incidence of femoroacetabular impingement (FAI) in patients with hip pain, researchers from Mayo Clinic, Rochester, Minnesota and The First Affiliated Hospital of Soochow University in Suzhou, China, set out to rectify that. Their work, “Incidence of Femoroacetabular Impingement and Surgical Management Trends Over Time,” appears in the January 1, 2021 edition of The Journal of Sports Medicine.

Co-author Aaron Krych, M.D., an orthopedic surgeon at Mayo Clinic, told OSN, “A couple of years ago, our clinical research team noticed that the number of patients presenting to clinic with hip pain was increasing. We noticed that many of these patients had structural hip deformities consistent with femoroacetabular impingement (FAI). Over the last 15-20 years the utilization of hip arthroscopy has only increased across the world, and this has certainly been the case at Mayo Clinic as well. As we investigated the literature, we realized that there was a lack of high-quality data defining the incidence of FAI and surgical trends over time.” …

NOTE: Dr. Krych and his colleagues used the Rochester Epidemiology Project to conduct this research.

Study Finds Similar Outcomes in Patients With, Without IBD and Rectal Cancer

Cancer Therapy Advisor, 1/14/2021

Although the risk of colorectal cancer (CRC) is increased in individuals with inflammatory bowel disease (IBD), no significant discrepancy in survival rates was identified among patients with rectal cancer and IBD vs those with rectal cancer without IBD, according to the results of a study published in Diseases of the Colon & Rectum.

A team of investigators from the Mayo Clinic, in Rochester, Minnesota, conducted a retrospective cohort study in which adult patients with IBD diagnosed with rectal cancer who had at least 1 year of postsurgical follow-up were included and paired with patients with rectal cancer who did not have IBD. The objective for the research was to identify and compare survival rates between the rectal cancer IBD group and the rectal cancer non-IBD counterparts. Outcomes included 5-year overall survival and disease-free survival, as well as 30-day postoperative complication, readmission, reoperation, and mortality rates. …

Adults with Cerebral Palsy Need Better Access to Health Care

Michigan Medicine – University of Michigan news release, 1/13/2021

A new commentary, published in Mayo Clinic Proceedingshighlights the state of scientific research, policies and health services available for adults with cerebral palsy, and advocates for improvements.

NOTE: Mayo Clinic Proceedings is a peer-reviewed journal that has been continuously published since 1926.

Podcast: And The Value Of An Additional Star For Physicians And Hospitals Is...

Health Affairs, 1/12/2021

… On this episode of A Health Podyssey, Alan Weil interviews Dr. Adam Schwartz, associate professor of orthopedic surgery at the Mayo Clinic College of Medicine and Science, who wrote a research paper with colleagues in the January 2021 issue of Health Affairs on the monetary value of an additional hospital or physician star rating when choosing a provider for total joint replacement.

NOTE: Adam Schwartz, M.D., is an orthopedic surgeon at Mayo Clinic in Phoenix, and a Kern Health Care Delivery Scholar. You can also read an article on the same research in Orthopedics Today from Healio.

New Clinical Decision Tool Predicts Survival Outcomes in Early-Stage TNBC

Cancer Therapy Advisor, 1/14/2021

Researchers developed a new prognostic tool based on a range of clinicopathologic, as well as patient- and treatment-specific variables, to predict the long-term clinical outcomes of patients with early-stage triple-negative breast cancer (TNBC), according to results of a study reported in Breast Cancer Research and Treatment.

… The training dataset for construction and internal validation of the prognostic model was comprised of a cohort of 605 patients who underwent primary surgery for the treatment of TNBC at the Mayo Clinic between 1985 and 2012. Breast cancer specimens from all the patients were retrospectively assessed for Ki67 expression level and the presence of stromal tumor infiltrating lymphocytes (sTIL).

Fecal Transplants Safe Long Term for Recurrent C. Diff

MedPage Today, 1/12/2021

— But new-onset conditions post-fecal microbiota transplantation need further study

More evidence has emerged for fecal microbiota transplantation (FMT) as a safe option for treating recurrent Clostridioides difficile infection (CDI), according to a survey-based study.

FMT was safe in both the short and long term with little risk of infection transmission, according to Sahil Khanna, MBBS, and colleagues, of the Mayo Clinic in Rochester, Minnesota.

However, several new medical conditions were seen in patients after FMT, in particular weight gain and irritable bowel syndrome (IBS), and "These should be explored further in future prospective studies," they wrote in Gastroenterology.

A High-Fiber Diet May Help Lower Depression Risk

Everyday Health, 1/12/2020

… new research suggests that women who eat a diet higher in fiber are less likely to be depressed than women who consume less fiber.

The study, published on January 6, 2021, in Menopause: The Journal of the North American Menopause Society, wasn’t designed to discover the why behind the link, but the authors speculate it’s because of fiber’s positive impact on gut health.

… The findings in this research are interesting, but the authors make a lot of assumptions, says Stephanie Faubion, MD, MBA, the director of the center for women’s health at the Mayo Clinic in Rochester, Minnesota, and medical director of the North American Menopause Society (NAMS). Dr. Faubion was not involved in the new research.

“They’re assuming that the direction of the association only goes one way, that the fiber intake is impacting the depression, and I think that’s incorrect,” she says. …

NOTE: Read the article for more from Dr. Faubion.

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Tags: Aaron Krych, Adam Schwartz, Alzheimer's disease, artificial intelligence, brain, breast cancer, C. diff, cerebral palsy, clinical trials, collaboration, colorectal cancer, COVID-19, depression, exercise, fecal transplant, Findings, gastroenterology, health care access, health care value, health disparities, IBD, IBS, Innovations, Katherine Zeratsky, Kern Health Care Delivery Scholars, Liza Torborg, Mayo Clinic Proceedings, menopause, Michelle Mielke, News, News of the Week, oncology, orthopedic surgery, orthopedics, pain management, People, Rochester Epidemiology Project, Ronald Petersen, S. Vincent Rajkumar, Sahil Khanna, shared decision making, social media, Stephanie Faubion, Stephen Kopecky, team science

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