Advancing the Science

Mayo Clinic Medical Science Blog – an eclectic collection of research- and research education-related stories: feature stories, mini news bites, learning opportunities, profiles and more from Mayo Clinic.

June 1, 2021

Mayo Clinic Research in the News — 6/1/2021

By Elizabeth Zimmermann

Today's summary reaches back an extra day, and covers acupuncture for insomnia, new artificial intelligence solutions,, carpal tunnel's connection to to bilateral oophorectomy, sublingual vaccines and showcases wide variety of other Mayo Clinic research and research expertise.

Research on inflammatory disease widens 

Gulf Today, 5/24/2021

An epidemiological study of Inflammatory Bowel Diseases (IBD) is being scheduled in Abu Dhabi as everyone has yet to fully understand the mystery of these set of conditions, which, among its complications, if undiagnosed or misdiagnosed is colorectal cancer.

"If all goes as planned, we will expand this venture further to include the entire country," Dr. Talha Aziz Malik told Gulf Today recently, adding that while many inconsistencies in collated studies have to be corrected, IBD rates in other parts of the globe, other than among the Caucasians in North America, Europe and Australia, have spiked tremendously…

NOTE: Dr. Malik was recently named director, IBD Center, Sheikh Shakhbout Medical Centre (SSMC). SSMC is a joint venture partnership of the Abu Dhabi Health Services Company and Mayo Clinic.

The future of COVID-19, Part 2: four drugs that worked

Inforum, 5/25/2021

So far, only a handful of medications have emerged from the tidal wave of research seeking new treatments for COVID-19.

NOTE: This article connects with some Mayo-specific information, and quotes Raymund Razonable, M.D.

Mayo Clinic appoints executive director of cancer programs

Healio, 5/30/2021

Cheryl Willman, MD, has been named executive director of Mayo Clinic cancer programs.

Willman also will serve as director of Mayo Clinic Comprehensive Cancer Center.

She will lead the expansion and strategic development of Mayo Clinic Comprehensive Cancer Center sites in Minnesota, Florida and Arizona, as well as Mayo Clinic cancer programs in Abu Dhabi and London.

Antibiotics, Kidney Injury and Joint Infection: New Mayo Study

Orthopedics This Week, 5/27/2021

When surgeons have to contend with a periprosthetic joint infection (PJI) after total knee arthroplasty (TKA), says a group of researchers from Mayo Clinic, most reach for the following solution, a 2-stage exchange arthroplasty with a high-dose antibiotic-loaded bone cement spacer and organism-specific intravenous (IV) or oral antibiotics. However, there is concern that a high dose of local antibiotics can spread systemically and harm the kidneys.

A new study addressing this issue, “Acute Kidney Injury When Treating Periprosthetic Joint Infections After Total Knee Arthroplasties with Antibiotic-Loaded Spacers,” was published in the May 5, 2021 edition of The Journal of Bone and Joint Surgery

Brian E. Lacy, MD, PhD: IBS-C Symptoms During COVID-19

HCPLive, 5/25/2021

A large proportion of IBS-C patients did not seek health care during the COVID-19 pandemic despite symptoms.

There is considerable disease burden for patients with irritable bowel syndrome with constipation (IBS-C) that was only exacerbated by the COVID-19 pandemic.

In data presented during the 2021 Digestive Disease Week (DDW) Virtual Meeting, a team of researchers led by Brian E. Lacy, MD, PhD, Gastroenterology, Neurogastroenterology, the Mayo Clinic, examined how the pandemic shaped disease presentation and health care utilization…

NOTE: Read the full article online or view video interview with Dr. Lacy.

Alzheimer’s drug sparks emotional battle as FDA nears deadline on whether to approve

The Washington Post, 5/30/2021

If cleared, the drug would be the first for slowing cognitive decline, but critics say the data does not prove it works

…"When you have one study that is positive and one that is negative, it seems to lead to an inability to draw a conclusion and therefore to a need for a third trial," said David S. Knopman, a Mayo Clinic neurologist who treats Alzheimer’s patients and is a member of the FDA advisory committee. He had recused from the November meeting because he has been a site investigator for aducanumab.

Five cancer researchers receive 2021 New Discoveries Young Investigator Awards from BCAN

The Cancer Letter, 5/28/2021

Five researchers have received the 2021 New Discoveries Young Investigator Awards from the Bladder Cancer Advocacy Network. 

…The 2021 New Discoveries Young Investigator Award for Patient Centered Research was awarded to Svetlana Avulova, urologic oncology fellow at Mayo Clinic. Avulova’s project is titled “Sexual Function in Women Undergoing Radical Cystectomy.”

How Acupuncture Can Optimize Sleep Patterns and Free You from Insomnia

Healthline, 5/28/2021

Tony Chon, MD, a general internal medicine specialist and expert in acupuncture at Mayo Clinic in Rochester, MN, says that, while there’s not enough evidence to prove acupuncture treats insomnia, he performs it on patients with sleep issues related to pain or anxiety.

“The potential gains outweigh the minimal risks,” Chon says. “From clinical experience and anecdotally, acupuncture appears to be very helpful. Many of my patients communicate a sense of calm after acupuncture that helps them sleep better for several days.”

NOTE: Dr. Chon is the practice chair, Mayo Clinic Complementary and Integrative Medicine Program.

Mayo Clinic AI could make it easier, cheaper to diagnose early-stage heart failure 

Morning Brew, 5/24/2021

The study found that AI screening yielded five new diagnoses for every 1,000 patients screened

…"The human clinician, if they look at this image, they will not [be able to] tell whether the patients have heart failure or not," Dr. Xiaoxi Yao, a health outcomes researcher at the Mayo Clinic and the study’s lead author, told us. "The AI sees something we clinicians cannot see….It’s quite new."

Man's Robotic Arm Works Faster With High-Tech Sense of Touch 

HealthDay News, 5/24/2021

…Experts said this research, reported May 20 in the journal Science, is an important advance in prosthetics technology.

"It has long been known that motor prosthetics need to take into account the external world in order to offer improved performance," said J. Luis Lujan, an associate professor of neurologic surgery at Mayo Clinic. "The work of this research team further demonstrates the importance of tactile and visual feedback in the control of movement, whether of an individual's own limbs or robotic devices."

NOTE: Dr. Lujan was not involved in this particular study.

AI Accelerates Fully Automated CT Segmentation of the Pancreas 

Diagnostic Imaging, 5/25/2021

3D Convolutional neural network can effectively replace manual segmentation of the pancreas with or without cancer.

Using a 3D convolutional neural network (CNN) opens the door for automatic segmentation of the pancreas on CT imaging to pinpoint biomarkers for both endocrine and exocrine disease, new research shows.

In a poster presented during the Society for Imaging Informatics in Medicine (SIIM) 2021 Virtual Annual Meeting, Panagiotis Korfiatis, Ph.D., assistant professor of radiology and senior associate consultant for artificial intelligence in the medical physics division in the Mayo Clinic’s radiology department, revealed how using a 3D CNN automates pancreas segmentation on CT to save time in patients with both normal pancreas or pancreatic ductal adenocarcinoma (PDA).

Extended TAILOR-PCI Data Again Show No Gains for Genotype-Guided Meds 

tctMD, 5/26/2021

Believing still in some benefit of testing, Naveen Pereira said the P value shouldn’t be viewed as “binary.”

A genotype-guided strategy for deciding on antiplatelet agents after PCI does not lead to improvements in long-term ischemic events, according to extended follow-up from TAILOR-PCI.

…Presenting their analysis—which included a median follow-up of 39 months—at the recent American College of Cardiology (ACC) 2021 Scientific Session, Naveen Pereira, MD (Mayo Clinic, Rochester, MN), stressed that the findings, while not what investigators had hoped, need to be viewed with caution. Patients in the genotype-guided group, he noted, were less likely to continue their P2Y12 inhibitor after 1 year, especially those on ticagrelor, compared with those in the conventional group…

NOTE: Read the article for more from Dr. Pereira.

Severe Carpal Tunnel Syndrome Up After Bilateral Oophorectomy 

HealthDay, 5/26/2021

Estrogen therapy after oophorectomy did not appear to have a protective effect

Premenopausal women who undergo bilateral oophorectomy have an increased risk for severe carpal tunnel syndrome (CTS), according to a study published online May 26 in Menopause.

Julia Starlinger, M.D., Ph.D., from the Mayo Clinic in Rochester, Minnesota, and colleagues examined whether bilateral oophorectomy is associated with the risk for severe CTS in a cohort of 1,653 premenopausal women who underwent bilateral oophorectomy for a nonmalignant indication between 1988 and 2007 and a random sample of 1,653 age-matched referent women. Diagnoses of CTS were identified during the entire lifetime in both cohorts.

NOTE: Dr. Starlinger is a research fellow in the Tendon and Soft Tissue Biology Laboratory of Peter C. Amadio, M.D. 

Minnesota researchers develop wafer as potential new vaccine delivery method 

KMSP, 5/26/2021

Researchers believe a newly developed wafer could be the vaccine-delivery device of the future. 

A University of Minnesota professor and a Mayo Clinic professor were part of the team of researchers that created a polymer wafer that can deliver and preserve vaccines when placed under the tongue.

Is There a Link Between COVID Vaccines and Heart Inflammation in Teens? 

Verywell Health, 5/27/2021

Leslie Cooper, MD, the co-founder and medical director of the Myocarditis Foundation and chair of the Department of Cardiovascular Medicine at the Mayo Clinic in Jacksonville, Florida, tells Verywell that most of the reported cases of myocarditis in teens who had recently been vaccinated were mild. The patients were treated with anti-inflammatory drugs such as ibuprofen and a drug called colchicine, and most have recovered without any long-term health problems.

VIDEO: Stool-based CRC screening promises cost effectiveness

Healio, 5/27/2021

In a video exclusive, Paul Limburg, MD, Mayo Clinic, told Healio adherence rates for stool-based colorectal cancer screening and colonoscopy informed comparative effectiveness and the need for improved screening and follow-up adherence.


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Tags: About, acupuncture, acute kidney injury, antibiotic, artificial intelligence, Awards, Brian Lacy, cardiovascular medicine, carpal tunnel syndrome, Cheryl Willman, clinical trials, colorectal cancer, COVID-19, David Knopman, Findings, heart failure, IBD, IBS, inflammation, inflammatory bowel disease, Innovations, insomnia, irritable bowel syndrome, J. Luis Lujan, Julia Starlinger, knee replacement, Leslie Cooper, Mayo Clinic Cancer Center, Naveen Pereira, neurology, News, News of the Week, oophorectomy, Panagiotis Korfiatis, pancreatic cancer, pancreatitis, Paul Limburg, People, Peter Amadio, radiology, Svetlana Avulova, Talha Aziz Malik, Tony Chon, vaccines, women's health, Xiaoxi Yao

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