At Mayo Clinic, biomedical, clinical and health care delivery research are ongoing. The evidence gathered by Mayo researchers, and other scientists, is used to ensure that patients receive the highest quality of care and achieve the best possible outcomes. Advancing the Science's Research News Roundup excerpts research-related news releases published in the last month. Read on for advancements in understanding of disease and new ways to improve the experience of health and health care for patients and health care professionals.
A review article by Mayo Clinic researchers emphasizes that early onset colorectal cancer, defined as being diagnosed when younger than 50, continues to steadily increase in the U.S. and other higher income countries. This increase, along with a decline in later-onset cases due primarily to screening have shifted the median age at diagnosis from 72 years in the early 2000s to 66 years now.
The risk of major complications for people who donate a kidney via laparoscopic surgery is minimal. That is the conclusion of a 20-year Mayo Clinic study of more than 3,000 living kidney donors. Only 2.5% of patients in the study experienced major complications, and all recovered completely.
"The results of this study are extremely reassuring for individuals who are considering being living kidney donors. We found that this lifesaving surgery, when performed at experienced transplant centers, is extremely safe," says Timucin Taner, M.D., Ph.D., chair of the Division of Transplant Surgery at Mayo Clinic's William J. von Liebig Center for Transplantation and Clinical Regeneration in Minnesota. Dr. Taner is a co-author of the study.
The study was published in Mayo Clinic Proceedings.
A test of protein in the blood gets further support as a biomarker for patients diagnosed with frontotemporal dementia, a group of brain disorders with few treatment options. These disorders are characterized by changes in behavior, cognition, language or movement.
In a new paper published in Cell Reports Medicine, Mayo Clinic researchers and members of the Advancing Research and Treatment in Frontotemporal Lobar Degeneration and Longitudinal Evaluation of Familial Frontotemporal Dementia Subjects studies, or ALLFTD Consortium, report that neurofilament light is a useful biomarker for frontotemporal dementia. This biomarker may allow for quicker diagnosis and participation in early treatment clinical trials.
Researchers at Mayo Clinic's Center for Individualized Medicine have devised an immunotherapy technique that combines chimeric antigen receptor-T cell therapy, or CAR-T cell therapy, with a cancer-killing virus to more effectively target and treat solid cancer tumors.
The combination approach, published in Science Translational Medicine, involves loading CAR-T cells, which are engineered to look for antigens on cancer cells, with an oncolytic virus. Oncolytic viruses are naturally occurring viruses that can infect and break down cancer cells. They either naturally replicate well in cancer cells or can be engineered to selectively target cancer cells.
Patients see a wide variety of medical professionals during a hospital stay, and it can be challenging for them to remember the titles and roles of everyone involved in their care. Many hospitals use name tags and other visual cues to help patients know who's providing their care, but misidentification remains an issue.
Resident physicians are often misidentified by patients and colleagues in hospitals, and it's especially common for female residents, according to an article published in Mayo Clinic Proceedings. Mayo researchers set out to learn whether the use of prominent role identifier badges can help reduce misidentification as well as resident physicians' perceptions of gender or racial bias.
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Information about many of the clinical trials available across Mayo Clinic is online as well.
Tags: biomarkers, brain, cancer, cancer prevention, CAR-T cell therapy, Center for Individualized Medicine, clinical trials, colorectal cancer, dementia, diversity, Findings, health equity, kidney transplant, living donor, Mayo Clinic Proceedings, News, organ donor, public health, Research News Roundup, Timucin Taner, Transplant Center, virotherapy