Advancing the Science

Mayo Clinic Medical Science Blog – an eclectic collection of research- and research education-related stories: feature stories, mini news bites, learning opportunities, profiles and more from Mayo Clinic.

Findings

If the article talks about a research paper, use this category

November 3, 2021

Transforming the practice of opioid prescribing — for kids

By Elizabeth Zimmermann Elizabeth Zimmermann (@elizabethzimmermann)

For children, the opioid epidemic can be about adults in their lives with opioid use disorder or accidental overdoses when a child finds their parent’s pill bottle. But kids can also get addicted to opioids. Mayo Clinic’s Courtney Baker, M.D., an orthopedic surgical resident, and his mentor, Todd Milbrandt, M.D., a pediatric orthopedic surgeon, decided […]

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Tags: Center for the Science of Health Care Delivery, collaboration, Courtney Baker, health care value, opioids, orthopedic surgery, pediatric research, quality improvement, research education, Tad Mabry, Todd Milbrandt


November 1, 2021

Regenerative technology uncovers new discoveries in liver disease

By Susan Buckles Susan Buckles (@susanbuckles)

Mayo Clinic researchers have developed a method for generating bile duct cells from stem cells. This technology enables them to study important aspects of primary sclerosing cholangitis, a rare bile duct disease that often destroys the liver. Using these regenerative technologies, Robert Huebert, M.D., and Nidhi Jalan Sakrikar, Ph.D., also confirmed that primary sclerosing cholangitis […]

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Tags: bile ducts, Center for Regenerative Medicine, liver disease, Nidhi Jalan Sakrikar, Robert Huebert


October 18, 2021

A regenerative reset for aging

By Susan Buckles Susan Buckles (@susanbuckles)

Regenerative medicine could slow the clock on degenerative diseases that often ravage the golden years, a Mayo Clinic study finds. Life span has nearly doubled since the 1950s, but health span — the number of disease-free years — has not kept pace. According to a paper published in NPJ Regenerative Medicine., people are generally living […]

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Tags: aging, Andre Terzic, Armin Garmany, Center for Regenerative Medicine, health span, regenerative medicine, Satsuki Yamada, senescent cells


October 12, 2021

What’s the best treatment for this condition? The Knowledge Synthesis team can help.

By Elizabeth Zimmermann Elizabeth Zimmermann (@elizabethzimmermann)

Knowledge synthesis is a key component  of health care delivery research in which all available evidence on a particular topic is summarized through comprehensive literature searches and analyzed using advanced qualitative and quantitative synthesis methods. The Knowledge Synthesis Program in the Mayo Clinic Robert D. and Patricia E. Kern Center for the Science of Health […]

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Tags: artificial intelligence, big data, Center for the Science of Health Care Delivery, clinical trials, Evidence-based Practice Center, health technology, Irbaz Riaz, kidney cancer, knowledge synthesis, liver disease, M. Hassan Murad, medical innovation


October 11, 2021

Platelet-rich plasma: A regenerative approach to healing chronic wounds

By Advancing the Science contributor Advancing the Science contributor (@advancingthescience)

By Madelyn Fell Platelet-rich plasma is the fraction of blood plasma that contains concentrations of platelets that are higher than baseline. Platelet-rich plasma attracts significant interest in the medical and research community since platelets possess various growth factors and cell parts that are critical for tissue repair and regeneration. Autologous platelet-rich plasma therapy uses injections of a […]

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Tags: Center for Regenerative Medicine, chronic wounds, diabetes, diabetic ulcers, Platelet-rich plasma, Wenchun Qu


October 5, 2021

Addressing corticophobia — Calming parents’ fears using the Rochester Epidemiology Project

By Elizabeth Zimmermann Elizabeth Zimmermann (@elizabethzimmermann)

Today’s parents face an almost constant bombardment of guidance, warnings, advice, anecdotal information and suppositions regarding their child’s health and wellbeing. Even the most well-read parents may struggle to find the facts among the fiction — or to figure out which facts are true for their child. This constant barrage of often conflicting information can […]

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Tags: Center for the Science of Health Care Delivery, cortisone, eczema, Reese Imhof, Rochester Epidemiology Project


October 4, 2021

Dispelling the hype of stem cell interventions

By Susan Buckles Susan Buckles (@susanbuckles)

Physicians need more resources, tools and education to counsel patients about emerging stem cell therapies, a study in Mayo Clinic Proceedings concludes. Interest in regenerative procedures is mushrooming along with an increase in chronic diseases that have few therapeutic options. The study examined how physicians at the intersection of complex conditions, regenerative discoveries and responsible […]

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Tags: bioethics, Center for Regenerative Medicine, stem cell therapy, Zubin Master


September 21, 2021

Antifibrotics may extend lives for patients with IPF

By Elizabeth Zimmermann Elizabeth Zimmermann (@elizabethzimmermann)

Mayo Clinic researchers recently learned that patients who are taking antifibrotic drugs for idiopathic pulmonary fibrosis (IPF) have a better chance of survival after a respiratory-related hospitalization compared to patients not receiving these medications. The study, which was supported by Three Lakes Foundation, was published recently in BMC Pulmonary Medicine. Read Three Lakes news release. […]

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Tags: Andrew Limper, Center for the Science of Health Care Delivery, idiopathic pulmonary fibrosis, OptumLabs


September 2, 2021

Understanding the inner workings of CAR-T therapy

By Susan Buckles Susan Buckles (@susanbuckles)

Mayo Clinic researchers have biomanufactured chimeric antigen receptor-T cell therapy  (CAR-T cell therapy) in a new way to track the cells’ cancer fighting journey and predict toxic side effects. This Mayo Clinic breakthrough, published in Cancer Immunology Research, also could unravel the mystery of how to unleash CAR-T cell therapy to destroy solid tumors. “This […]

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Tags: CAR-T, Center for Individualized Medicine, Center for Regenerative Medicine, chimeric antigen receptor therapy, clinical research, clinical trials, hematology, immunotherapy, Kah Whye Peng, Reona Sakemura, Saad Kenderian, Stephen Russell


August 30, 2021

Regenerating the rotator cuff

By Susan Buckles Susan Buckles (@susanbuckles)

Preclinical studies discovered a cell-free bioactive material developed at Mayo Clinic triggered healing of one of the most common shoulder injuries. This Mayo Clinic research, published in Biomaterials, documented that purified exosome product —  also known as PEP — promoted repair of rotator cuff injuries faster and more effectively than surgery alone. The rotator cuff […]

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Tags: Center for Regenerative Medicine, Chungfeng Zhao, extracellular vesicles


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