Advancing the Science

Mayo Clinic Medical Science Blog – an eclectic collection of research- and research education-related stories: feature stories, mini news bites, learning opportunities, profiles and more from Mayo Clinic.

Innovations

Exciting new things. Not a catch-all for all research.

November 24, 2022

The future will be personalized: Accelerating microbiome research

By Advancing the Science contributor Advancing the Science contributor (@advancingthescience)

We’re in the midst of a microbiome research epidemic, according to Purna Kashyap, M.B.B.S., co-associate director of the Microbiome Program in the Mayo Clinic Center for Individualized Medicine. “We started early and are pushing hard,” says Dr. Kashyap. “We’re one of the top accelerators in the field and are well poised to move microbiome research findings to […]

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Tags: arthritis, C. diff, cancer, Center for Individualized Medicine, colitis, colorectal cancer, diabetes, endometrial cancer, Francis Farraye, gastroenterology, gut health, gynecology


November 17, 2022

Focus on community practice: Real-world research fuels better outcomes

By Advancing the Science contributor Advancing the Science contributor (@advancingthescience)

It’s a Catch-22. You can’t improve community practice without evidence-based research, but it’s challenging to incorporate research into a busy primary care practice. And there’s a paucity of researchers devoted to primary care. “We’re busy seeing patients and trying to deliver the best care possible. It’s hard to find time to pause, step back and […]

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Tags: Center for Clinical and Translational Science, Center for Health Equity and Community Engagement Research, community engagement, geriatrics, palliative care, Prathibha Varkey, primary care, Rozalina McCoy, rural health care


October 4, 2022

AI enables early identification, intervention in debilitating lung disease

By Elizabeth Zimmermann Elizabeth Zimmermann (@elizabethzimmermann)

In a new study published in Nature Medicine, Mayo Clinic and several research collaborators from across the U.S., describe a successful new artificial intelligence, or AI, -enabled tool to identify idiopathic pulmonary fibrosis, also called IPF, before patients have recognizable symptoms. This tool could alert a patient’s primary care team of a probable IPF diagnosis […]

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Tags: artificial intelligence, big data, Center for the Science of Health Care Delivery, clinical informatics, collaboration, idiopathic pulmonary fibrosis, patient reported outcomes, pulmonary and critical care medicine, shared decision making, team science


August 30, 2022

Biomanufacturing 101: Understanding a new era of therapeutics

By Susan Buckles Susan Buckles (@susanbuckles)

Advancing discoveries such as cellular therapies from clinical trials to commercial therapy is a cornerstone of Mayo Clinic’s strategic emphasis on biomanufacturing. The long-term vision is to provide new cures for patients with unmet needs. “Biomanufacturing is a type of manufacturing that utilizes sources from the human body — cells, blood, enzymes, tissues, genes or […]

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Tags: biologics, biomanufacturing, CAR-T cell therapy, Center for Regenerative Medicine, Julie Allickson, regnerative biotherapeutics


August 2, 2022

Addressing the challenges of chimeric antigen receptor-T cell therapy

By Advancing the Science contributor Advancing the Science contributor (@advancingthescience)

Article by Marla Broadfoot Chimeric antigen receptor-T cell therapy (CAR-T cell therapy) — a type of immunotherapy that reprograms a patient’s T cells to recognize and destroy cancer cells — has revolutionized the treatment of blood cancers. While the technique has successfully sent patients with advanced disease into remission, it is far from perfect. CAR-T […]

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Tags: cancer therapy, CAR-T cell therapy, Center for Regenerative Medicine, Hong Qin, regenerative immunotherapy, Saad Kenderian


July 28, 2022

Bringing regenerative technology of the future to patients today

By Susan Buckles Susan Buckles (@susanbuckles)

“The sky’s the limit,” “possibility” and “potential cure for disease” are aspirational ways Mayo Clinic physicians and scientists described regenerative medicine in a recent virtual presentation at the World Stem Cell Summit 2022. Mayo’s panel discussion showcased how it is advancing regenerative medicine through industry collaborations that accelerate scientific discoveries to early stage clinical trials. […]

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Tags: 3D printing, Abba Zubair, biomanufacturing, Center for Regenerative Medicine, David Lott, Julie Allickson, Saranya Wyles, tissue engineering, World Stem Cell Summit


June 15, 2022

Research News Roundup — May 2022

By Advancing the Science contributor Advancing the Science contributor (@advancingthescience)

In May, researchers from Mayo Clinic reported gains in understanding of the benefit of AI-enabled ECGs, including from wearable devices. They made strides towards more effective treatment of non-Hodgkin lymphoma and nonmetastatic gastroesophageal cancer. And in news many people can use, investigators report on the results of a survey linked to the Mayo Clinic Diet. […]

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Tags: AFib, artificial intelligence, atrial fibrillation, CAR-T cell therapy, Center for the Science of Health Care Delivery, clinical trials, cognitive impairment, EKG, electrocardiogram, esophageal cancer, gastric cancer, gastroesophageal cancer


June 9, 2022

Biomedical innovators pitch ideas at Roadrunner Sprint competition

By Advancing the Science contributor Advancing the Science contributor (@advancingthescience)

Mayo Clinic innovations and innovators were highlighted during the second annual Roadrunner Sprint, which was held May 5 at the Arizona State University Health Futures Center Auditorium. The Roadrunner Sprint is organized and sponsored by the Mayo Clinic Office of Entrepreneurship. In this “Shark Tank”-like event, 10 teams of Mayo staff entrepreneurs pitched their solutions to […]

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Tags: Ami Shah, Anu Sreedhar, Center for Clinical and Translational Science, Dharmendra Patel, entrepreneurship, Office of Entrepreneurship, Richard Gray


May 31, 2022

Mayo research using DNA to catch cancer, other medical conditions earlier

By Adam Harringa Adam Harringa (@harringaadam)

What would happen if a certain percentage of serious medical conditions, including cancer diagnoses, were found significantly earlier by studying the entire genome of patients’ DNA? How would their quality of life improve, and how many fewer cancer deaths would there be each year? That’s what a group of Mayo Clinic scientists and clinicians aim […]

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Tags: Bijan Borah, breast cancer, Center for Individualized Medicine, Center for the Science of Health Care Delivery, Centers for Disease Control and Prevention, DNA, genome, genomics, health disparities, hereditary cancer, hereditary diseases, hypercholesterolemia


May 23, 2022

Saranya Wyles: Regenerating damaged skin

By Susan Buckles Susan Buckles (@susanbuckles)

When she was just 8 years old, Saranya Wyles, M.D., Ph.D., would recite the stages of wound healing in Latin terms — rubor, tumor, calor, dolor and functio laesa— to her father at the dinner table. Decades later, that ingrained knowledge would be a cornerstone of her regenerative medicine research, education and practice at Mayo […]

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Tags: Center for Regenerative Medicine, dermatology, education, Saranya Wyles, senescent cells, skin regeneration, wound healing, zombie cells


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