Advancing the Science

Mayo Clinic Medical Science Blog – an eclectic collection of research- and research education-related stories: feature stories, mini news bites, learning opportunities, profiles and more from Mayo Clinic.

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Mayo Clinic research and research education news

October 4, 2022

AI enables early identification, intervention in debilitating lung disease

By Elizabeth Zimmermann Elizabeth Zimmermann (@elizabethzimmermann)

In a new study published in Nature Medicine, Mayo Clinic and several research collaborators from across the U.S., describe a successful new artificial intelligence, or AI, -enabled tool to identify idiopathic pulmonary fibrosis, also called IPF, before patients have recognizable symptoms. This tool could alert a patient’s primary care team of a probable IPF diagnosis […]

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Tags: artificial intelligence, big data, Center for the Science of Health Care Delivery, clinical informatics, collaboration, idiopathic pulmonary fibrosis, patient reported outcomes, pulmonary and critical care medicine, shared decision making, team science


September 29, 2022

Mayo Clinic study indicates rural US counties have higher diabetes-related deaths

By Colette Gallagher Colette Gallagher (@colettegallagher)

In a new study, Mayo Clinic researchers identified substantial health disparities in rural versus urban areas in diabetes-related deaths, with other disparities based on gender. Using nationwide data from the Centers for Disease Control and Prevention, the researchers examined rates and trends from 1999 to 2018, in diabetes-related deaths among adults based on county urbanization, […]

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Tags: Adrian Vella, diabetes, endocrinology, epidemiology, health disparities, heart health, multiple chronic conditions, rural health care, Sagar Dugani


September 27, 2022

Physician-scientist investigates dual CAR-T cell therapy for multiple myeloma cancer

By Susan Murphy Susan Murphy (@susanmurphy)

Leo Sakemura, M.D., Ph.D., a physician-scientist in Mayo Clinic’s Division of Hematology, is working to advance immunotherapy efficacy in multiple myeloma by uncovering treatment resistance mechanisms and developing a more potent immunotherapy approach. His strategy focuses on simultaneously targeting cancer cells and the ecosystem surrounding each tumor, known as the tumor microenvironment.  Dr. Sakemura’s previous […]

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Tags: cancer genomics, cancer research, CAR-T cell therapy, Center for Individualized Medicine, hematology, immunotherapy, Leo Sakemura, metabolomics, multiple myeloma


September 26, 2022

Meet Khushboo Gala, M.B.B.S. — Finding fulfillment in helping others

By Advancing the Science contributor Advancing the Science contributor (@advancingthescience)

Khushboo S. Gala, M.B.B.S. is a gastroenterology fellow in the Mayo Clinic School of Graduate Medical Education. She cares for patients and conducts clinical research at Mayo Clinic in Rochester, Minnesota. Dr. Gala recently became a Kern Health Care Delivery Scholar, commencing a mentored training and research program within the Mayo Clinic Robert D. and […]

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Tags: Andres Acosta, Center for the Science of Health Care Delivery, Juan Brito Campana, Kern Health Care Delivery Scholars, Khushboo Gala, Mayo Clinic School of Graduate Medical Education, obesity, Victor Montori


September 22, 2022

A preclinical step toward treating chronic dry mouth

By Susan Buckles Susan Buckles (@susanbuckles)

Mayo Clinic researchers replicated chronic dry mouth from radiation damage in preclinical models, laying the foundation for stem cell research to regenerate salivary tissue after cancer. This discovery uses targeted X-radiation to mimic human injury and establish a lab model for testing cellular therapies for dry mouth. The study is published in Radiation Research. “The […]

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Tags: basic science, Center for Regenerative Medicine, discovery research, dry mouth, head and neck cancer, Jeffrey Janus, medical research, Nagarajan Kannan, otolaryngology, quality of life, radiation therapy, salivary glands


September 21, 2022

Maintaining quality care for patients with ALS — Lessons from the pandemic

By Advancing the Science contributor Advancing the Science contributor (@advancingthescience)

By Susan Barber Lindquist The efficiency and effectiveness of telemedicine exploded during the COVID-19 pandemic. For patients with Lou Gehrig’s disease, also known as amyotrophic lateral sclerosis or ALS, telemedicine always has been an important piece of their medical care. A recent study in Neurology by Mayo Clinic researchers offers one more proof point. Tests […]

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Tags: ALS, amyotrophic lateral sclerosis, clinical trials, COVID-19, Lou Gehrig's disease, Nathan Staff, neurology, remote patient monitoring, telehealth, telemedicine


September 20, 2022

Mayo Clinic researchers integrate genomics into kidney disease diagnosis, care

By Colette Gallagher Colette Gallagher (@colettegallagher)

Genomic testing results evaluated by a team of Mayo Clinic researchers, coupled with the latest research techniques, provided a definitive diagnosis for 30.7% of families with unexplained chronic kidney disease or stones, as reported in a 2021 study published in Kidney Medicine, a Journal of the National Kidney Foundation. The study obtained the highest diagnostic yield in people with […]

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Tags: Center for Individualized Medicine, genomics, kidney disease


September 15, 2022

Meet Gustavo Cortes Puentes, M.D. — Compassionate Clinician Scientist

By Advancing the Science contributor Advancing the Science contributor (@advancingthescience)

Gustavo Cortes Puentes, M.D. (@DrivingPressure), is a pulmonary and critical care specialist at Mayo Clinic in Rochester, Minnesota. Originally from Colombia, he came to Mayo by way of an internal medical residency with the University of Minnesota Medical School in Minneapolis, following a research scholar appointment during which he studied pulmonary mechanics and acute respiratory […]

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Tags: Caroline Davidge-Pitts, Cassie Kennedy, Center for Health Equity and Community Engagement Research, Center for the Science of Health Care Delivery, Cesar Gonzalez, diversity, Gustavo Cortes Puentes, health disparities, Kaiser Lim, Kern Health Care Delivery Scholars, pulmonary and critical care medicine, Sean Phelan


September 13, 2022

Mayo Clinic study reveals aging speeds genomic mutations in brain

By Colette Gallagher Colette Gallagher (@colettegallagher)

Somatic mutations naturally occur in cells throughout human development and during aging. However, it has yet to be determined whether the frequency of somatic mutations in the population are a contributing factor to the cause of neuropsychiatric disorders, cancers, and various diseases. Alexej Abyzov, Ph.D., a Mayo Clinic genomics researcher, seeks to gain a better […]

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Tags: brain, Center for Individualized Medicine, genomics, neurology


September 8, 2022

A new name for Center for Regenerative Medicine

By Susan Buckles Susan Buckles (@susanbuckles)

Mayo Clinic’s Center for Regenerative Medicine has been renamed the Center for Regenerative Biotherapeutics. The name change reflects Mayo’s new strategic focus: manufacturing next-generation biotherapeutics for patients. The new name emphasizes how regenerative medicine at Mayo Clinic has evolved to advance groundbreaking discoveries toward curative products — biotherapeutics — for patients. The Center for Regenerative […]

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Tags: Cell therapy, Center for Regenerative Biotherapeutics, gene therapy, Julie Allickson


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