Advancing the Science

Mayo Clinic Medical Science Blog – an eclectic collection of research- and research education-related stories: feature stories, mini news bites, learning opportunities, profiles and more from Mayo Clinic.

republished

January 14, 2021

3 things to consider before preserving your stem cells

By Susan Buckles Susan Buckles

The proliferating stem cell banking industry is built on a riveting concept: Preserve stem cells while they’re most potent until they are needed later in life to potentially fight disease. What started out as a market for banking stem cells from a baby’s umbilical cord blood and tissue is mushrooming into an industry that now […]

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Tags: Andre Terzic, biobank, bioethics, biomedical ethics, Center for Regenerative Medicine, stem cell research, stem cell therapy, stem cells, Zubin Master


January 12, 2021

Physicians have new guidelines for managing rare genetic, metabolic disorders

By Susan Murphy Susan Murphy

Physicians now have a blueprint for diagnosing and managing two specific rare inherited metabolic diseases within a group of nearly 150 congenital disorders of glycosylation. These diseases can cause serious and sometimes fatal malfunctions of several organs at or before birth, as well as chronic debilitating symptoms in adults.  The consensus guidelines were published in […]

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Tags: Center for Individualized Medicine, clinical research, Eva Morava-Kozicz, genetics, genomics, hereditary diseases, metabolomics, rare disease


January 6, 2021

Diverse ways regenerative medicine is advancing health care

By Susan Buckles Susan Buckles

Regenerative medicine has contributed to patient care in 2020 more than ever before, bolstered by synergies in research, practice and education. Mayo Clinic’s Center for Regenerative Medicine is at the forefront of a biotherapy revolution in which health care advances from treating disease to restoring health. “The centrality of the body to regenerate itself is […]

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Tags: 3D printing, Andre Terzic, artificial intelligence, Atta Behfar, autoimmune disorder, biomedical engineering, CAR T-cell therapy, Center for Regenerative Medicine, clinical research, clinical trials, data science, fetal surgery


December 29, 2020

Ingenuity, collaboration, and expertise create a game-changing COVID-19 test swab

By Advancing the Science contributor Advancing the Science contributor

Faced with potential shortages, a straightforward assignment — find more swabs — became a massive effort that involved numerous departments and experts, and culminated in Mayo Clinic designing, testing and manufacturing a new medical device. By Tracy Will Swabs typically don’t attract much attention. Small, simple, inexpensive, used quickly and discarded, they hardly seem to […]

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Tags: 3D printing, Bobbi Pritt, collaboration, COVID-19, Department of Laboratory Medicine and Pathology, Jonathan M. Morris, Joseph Yao, lab medicine, Mayo Clinic Laboratories, medical innovation, Paul Jannetto, team science


December 28, 2020

Mayo study explores benefits of genetic testing for healthy people

By Colette Gallagher Colette Gallagher

More than 1 in 10 people who had predictive genomic testing ― testing that looks for genetic mutations in otherwise healthy people ― learned that they had a hereditary risk for a health condition and may benefit from preventive care, according to a recent study published in Mayo Clinic Proceedings. This study is the first to […]

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Tags: Center for Individualized Medicine, gene mutation, genetic counseling, genetic testing, genomics, hereditary diseases, individualized medicine, Mayo Clinic Proceedings, personalized medicine


December 23, 2020

Mayo study shows gene sequencing, translational research improves diagnosis rates

By Colette Gallagher Colette Gallagher

Many patients with unsolved medical mysteries often undergo genetic testing, but the tests do not always provide a conclusive diagnosis. The term “diagnostic odyssey” describes the series of clinical consultations and testing that patients with undiagnosed disorders often receive in search of a genetic diagnosis. To help these patients, Mayo Clinic researchers embarked on a […]

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Tags: Center for Individualized Medicine, clinical research, diagnostic odyssey, Eric Klee, genetic testing, genome, Konstantinos Lazaridis, rare disease


December 16, 2020

A regenerative detour for lymphedema

By Susan Buckles Susan Buckles

Mayo Clinic is refining its regenerative approach to treating lymphedema, a debilitating buildup of fluid after cancer treatment. Research by Antonio Forte, M.D., Ph.D., a Mayo Clinic plastic surgeon, seeks to better pinpoint who is most likely to benefit from surgery aimed at regenerating a faulty lymphatic system. Mayo Clinic’s Center for Regenerative Medicine supports […]

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Tags: Antonio Forte, cancer, Center for Individualized Medicine, Center for Regenerative Medicine, lymphedema


December 9, 2020

Diversifying genomic medicine beyond genes

By Colette Gallagher Colette Gallagher

The work to improve health and health care is ongoing and ever-evolving. It takes many shapes, from streamlining delivery to improving care and pursuing inclusive medical research to help develop precision medicine for all populations. This was a key element of the Arizona Return of Actionable Variants Empirical, or RAVE, study, which brought genomic medicine to […]

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Tags: biomedical ethics, Center for Individualized Medicine, clinical trials, diversity, DNA, genetics, genomics, health disparities, Iftikhar Kullo, Richard Sharp


December 8, 2020

How COVID-19 empowered regenerative sciences students for success

By Susan Buckles Susan Buckles

Training the workforce of the future is a strategic priority of Mayo Clinic’s Center for Regenerative Medicine. Sometimes the most valuable lessons come from outside the classroom. This year, regenerative sciences students readily adapted to a stealthy foe that exploded on the scene, seemingly from nowhere. The COVID-19 pandemic triggered a rapid conversion to online […]

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Tags: CAR-T, Center for Regenerative Medicine, Claudia Manriquez Roman, COVID-19, Dileep Monie, gene therapy, immunology, Mayo Clinic Alix School of Medicine, Mayo Clinic Graduate School of Biomedical Sciences, medical research, Naga Rallabandi, research education


December 2, 2020

Conquering cancer by targeting its genetic abnormalities

By Susan Murphy Susan Murphy

Joanne Garnett has harrowing memories of that life-changing day back in 1981. She was a 39-year-old land use planner living in Wyoming when she received a call from her doctor confirming she had uterine cancer.  “I was shocked, and it was strange because I didn’t fit any profile for uterine cancer,” Garnett recalls. “I got a […]

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Tags: BRCA2, breast cancer, cancer genomics, Center for Individualized Medicine, clinical research, DNA, gene mutation, genetic testing, hereditary cancer, Lynch syndrome, Mayo Clinic Cancer Center, Niloy "Jewel" Samadder


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