Advancing the Science

Mayo Clinic Medical Science Blog – an eclectic collection of research- and research education-related stories: feature stories, mini news bites, learning opportunities, profiles and more from Mayo Clinic.

republished

February 20, 2020

Restoring function with larynx transplantation

By Jennifer Schutz Jennifer Schutz

Mayo Clinic has launched a first of its kind regenerative transplant program aimed at restoring function for people who need their larynx, or voice box, removed. In the United States about 60,000 people are living without a larynx, due to disease or trauma. The larynx is a segment of the respiratory tract located in the […]

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Tags: Center for Regenerative Medicine, D. Eric Steidley, David Lott, larynx transplant, regenerative medicine, transplant


February 18, 2020

Mayo researchers studying ‘promising’ new approach to treating advanced cancer, 1 patient at a time, 1 tumor at a time

By Susan Murphy Susan Murphy

A collaborative team of Mayo Clinic scientists is studying an innovative strategy for treating advanced cancer, using genomics and human tumor samples as their guide. The novel approach, called Ex Vivo, creates a miniature cancer replica for testing therapies outside a patient’s body, combined with a comprehensive genomic analysis of a patient’s cancer cells. “We […]

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Tags: biomarkers, cancer, cancer genomics, Center for Individualized Medicine, genomics, George Vasmatzis, individualized medicine, Mayo Clinic Cancer Center, Minetta Liu, Panos Anastasiadis, personalized medicine


February 17, 2020

AI system helps individualize treatment people diagnosed with depression

By Advancing the Science contributor Advancing the Science contributor

When searching for an exact diagnosis through a myriad of complex and serious factors spread across millions of data points, it helps to have a powerful magnifying glass — and another expert point of view. Enter Arjun Athreya, Ph.D., an engineer by trade who has a knack for bringing together data science algorithms and computing […]

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Tags: Arjun Athreya, artificial intelligence, collaboration, data science, depression, individualized medicine, pharmacology, precision medicine, team science, University of Illinois Urbana-Champaign, William Bobo


February 14, 2020

Filling hearts instead of test tubes

By Advancing the Science contributor Advancing the Science contributor

Editor’s note: This story is not about Mayo Clinic research, but rather about a part of a researcher’s life that builds hope in little hearts, and gives him joy. It’s 10 a.m. on a Thursday, and Merrick Ducharme is up to his elbows (OK, his wrists) in slime. The gooey, gluey mixture is not one […]

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Tags: Mayo Clinic Children's Center, research


February 10, 2020

Regenerative product could provide new option for women with mesh exposure following pelvic reconstructive surgery

By Jennifer Schutz Jennifer Schutz

Research is advancing a regenerative solution for a quality of life-limiting complication of mesh-based surgical repairs for stress urinary incontinence and pelvic organ prolapse in women. While mesh-based surgical treatments are durable and provide symptom relief for a great number of patients, there is a risk of mesh complications following surgery, such as mesh exposure. […]

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Tags: Cassandra Kisby, Center for Regenerative Medicine, John Occhino, regenerative medicine, urinary incontinence, vaginal prolapse, women's health


February 5, 2020

“I Just Didn’t Understand”: On a Mission to Cure ALS

By Advancing the Science contributor Advancing the Science contributor

By Barbara J. Toman For Veronique Belzil, Ph.D., the fight against amyotrophic lateral sclerosis (ALS) is personal. In 2000, while working as a psychologist in Canada, she watched her husband’s uncle succumb to the disease. “The progression was so fast and his condition was so sad,” she says. “I just didn’t understand how this could […]

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Tags: ALS, amyotrophic lateral sclerosis, Center for Individualized Medicine, DNA, epigenetics, Lou Gehrig's disease, Veronique Belzil


January 31, 2020

How a love for learning inspired an investment in physicians of the future

By Advancing the Science contributor Advancing the Science contributor

Jay Alix grew up surrounded by an unlikely team of experts. That, and a supportive community, gave him a push that turned him into a world-class business leader. Now a member of the Mayo Clinic Board of Trustees, he’s sharing his legendary business acumen to help Mayo Clinic educate the next generation of physician-scientists and […]

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Tags: Gianrico Farrugia, John Noseworthy, Mayo Clinic Alix School of Medicine, Mayo Clinic Model of Research, medical innovation, research, research education


January 30, 2020

A breakthrough in distinguishing benign adrenal tumors from cancerous ones

By Advancing the Science contributor Advancing the Science contributor

By Christoph Bahn Approximately 80 million CT scans are performed in the United States every year. Adrenal tumors are found incidentally in about 5% of these scans. Most of these tumors will turn out to be benign, but a small fraction will be adrenal cortical carcinoma, a type of cancer with high mortality and frequent recurrence; even for […]

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Tags: adrenal tumors, biomarkers, biopsy, cancer, clinical research, CT, endocrine cancer, endocrinology, epidemiology, hormones, Irina Bancos, Mayo Clinic Laboratories


January 27, 2020

Neuro regeneration for chemo brain: Mi-Hyeon Jang, Ph.D.

By Jennifer Schutz Jennifer Schutz

Cognitive dysfunction, sometimes called “chemo brain,” stemming from chemotherapy is a major adverse condition affecting approximately 14 million cancer patients and survivors in the United States. Although chemo brain has been widely reported by patients and clinicians, the cause of concentration and memory problems in cancer patients is not well understood. Mayo Clinic researchers are […]

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Tags: cancer, Center for Regenerative Medicine, chemo brain, chemotherapy, Mayo Clinic Cancer Center, Mi-Hyeon Jang, neuroregeneration, regenerative medicine, Regenerative Medicine Minnesota, stem cells


January 23, 2020

Mayo Clinic research discovers a molecular switch for repairing central nervous system disorders

By Susan Buckles Susan Buckles

A molecular switch has the ability to turn on a substance in animals that repairs neurological damage in disorders such as multiple sclerosis (MS), Mayo Clinic researchers discovered. The early research in animal models could advance an already approved Food and Drug Administration therapy and also could lead to new strategies for treating diseases of the central nervous […]

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Tags: Alzheimer's disease, autoimmune disorder, basic science, Center for Regenerative Medicine, demyelination, discovery research, Isobel Scarisbrick, multiple sclerosis, neurology, schizophrenia, spinal cord injury


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