Advancing the Science

Mayo Clinic Medical Science Blog – an eclectic collection of research- and research education-related stories: feature stories, mini news bites, learning opportunities, profiles and more from Mayo Clinic.

republished

September 28, 2021 · Leave a Comment

An inside look at the state-of-the-art supports enabling invention

By Advancing the Science contributor Advancing the Science contributor (@advancingthescience)

Throughout Mayo Clinic, innovation is the thread that weaves through countless initiatives aimed at improving patient care. While Mayo’s most cutting-edge discoveries are often widely known, the vast majority of innovative endeavors occur behind the scenes. One of the more low-profile assets in Mayo Clinic Laboratories’ innovation arsenal is the media kitchen, where specialized media […]

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Tags: biomedical engineering, Mayo Clinic Laboratories


September 2, 2021 · Leave a Comment

Understanding the inner workings of CAR-T therapy

By Susan Buckles Susan Buckles (@susanbuckles)

Mayo Clinic researchers have biomanufactured chimeric antigen receptor-T cell therapy  (CAR-T cell therapy) in a new way to track the cells’ cancer fighting journey and predict toxic side effects. This Mayo Clinic breakthrough, published in Cancer Immunology Research, also could unravel the mystery of how to unleash CAR-T cell therapy to destroy solid tumors. “This […]

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Tags: CAR-T, Center for Individualized Medicine, Center for Regenerative Medicine, chimeric antigen receptor therapy, clinical research, clinical trials, hematology, immunotherapy, Kah Whye Peng, Reona Sakemura, Saad Kenderian, Stephen Russell


August 16, 2021 · Leave a Comment

The dawning of regenerative neurosurgery

By Susan Buckles Susan Buckles (@susanbuckles)

Regenerative neurosurgery is poised to transform care of neurological disorders that previously had little hope for improvement, according to a Mayo Clinic review published in The BMJ. Healing diseases of the central nervous system remains a highly coveted but formidable challenge, Terry Burns, M.D., Ph.D., a neurosurgeon scientist at Mayo Clinic, writes in a synopsis […]

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Tags: amyotrophic lateral sclerosis, Center for Regenerative Medicine, clinical research, clinical trials, neurosurgery, spinal cord injury, Terrence Burns, The BMJ


July 27, 2021 · Leave a Comment

“I wouldn’t be where I am without his mentorship”

By Advancing the Science contributor Advancing the Science contributor (@advancingthescience)

It was the mid-1980s, and they bonded over grits, eggs and sausages. Onye Akwari, M.D., Department of Surgery at Duke University in Durham, North Carolina, and Kamal Itani, M.D., a research fellow in Dr. Akwari’s lab. Dr. Akwari took Dr. Itani, who had completed medical school at the American University of Beirut in his native […]

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Tags: Kamal Itani, Mayo Clinic Graduate School of Biomedical Sciences, Onye Akwari, research education


July 22, 2021 · Leave a Comment

Dr. Fischer wants to improve the health of children everywhere

By Advancing the Science contributor Advancing the Science contributor (@advancingthescience)

Philip (Phil) Fischer, M.D., says he’s always been interested in improving the health of children everywhere. He earned a diploma in tropical medicine and hygiene from the Liverpool School of Tropical Medicine in England to enhance his ability to do so. He worked at a medical center in what is now the Democratic Republic of […]

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Tags: gastroenterology, Mark Topazian, pediatric gastroenterology, pediatric research, Philip Fischer, Sheikh Shakhbout Medical Center


July 21, 2021 · Leave a Comment

Mayo researchers develop algorithm to predict rheumatoid arthritis disease activity

By Susan Murphy Susan Murphy (@susanmurphy)

Researchers within Mayo Clinic’s Center for Individualized Medicine and Division of Rheumatology have developed a first-of-its-kind machine learning algorithm that can predict rheumatoid arthritis disease activity in a patient. The algorithm analyzes biochemical metabolites ― the product of the body’s metabolism ― in blood. “Having fast, reliable and scalable measures for predicting the clinical course of disease […]

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Tags: arthritis, artificial intelligence, autoimmune disorder, biomarkers, Center for Individualized Medicine, clinical research, genomics, Jaeyun Sung, John Davis III, metabolism, metabolomics, rheumatology


June 25, 2021 · Leave a Comment

Could regenerative medicine relieve neck, back pain?

By Susan Buckles Susan Buckles (@susanbuckles)

Mayo Clinic is looking to regenerative medicine as a potential long-term solution for degenerative disk disease that has for years eluded medical science. Millions of people in the U.S. are afflicted with chronic neck and back pain that often comes after years of wear and tear on the spine. Current treatments provide only temporary relief […]

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Tags: Center for Regenerative Medicine, degenerative disease, inflammation, mesenchymal stem cells, pain management, platelet rich plasma, Wenchun Qu


June 17, 2021 · Leave a Comment

Regenerative pipeline for spinal cord repair

By Sara Tiner Sara Tiner (@saratiner)

Mayo Clinic researchers are learning how stem cell therapy can treat neurodegenerative diseases. Mayo is among the first to study whether stem cell therapy might trigger healing for spinal cord injury. Research is ongoing in preclinical models, but it also has advanced from discovery science to early clinical trials. It’s a complex question, because different […]

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Tags: animal model, Anshit Goyal, Anthony Windebank, Bingkun Chen, Center for Regenerative Medicine, clinical trials, F. M. Moinuddin, medical research, mesenchymal stem cells, Mohamad Bydon, Mohammed Ali Alvi, spinal cord injury


June 8, 2021 · Leave a Comment

Mayo researchers articulate implications of Omic-Medicine Era – What needs to happen with each stakeholder?

By Colette Gallagher Colette Gallagher (@colettegallagher)

In the near future, genome sequencing, among other biological measures, will be as routine as X-rays and cholesterol testing. The challenge, though, will be accurately interpreting the vast amount of data and effectively using it to guide decisions about health care. In a position statement published in Hepatology, Mayo Clinic researchers layout perspectives of various stakeholders […]

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Tags: Arjun Athreya, artificial intelligence, big data, bioethics, Center for Individualized Medicine, data science, genetic testing, genetics, genomics, Konstantinos Lazaridis, patient experience, population health


June 2, 2021 · Leave a Comment

Researchers develop new technique to study ‘microcancers’ and screen cancer-fighting drugs

By Advancing the Science contributor Advancing the Science contributor (@advancingthescience)

A team from the University of Illinois Urbana-Champaign’s Grainger College of Engineering and Mayo Clinic have developed a new technique for creating “microcancer” cell cultures. It allows researchers to form hundreds of microcancers in a high-throughput format using a small, microfabricated chip, enabling direct measurement of cell health or response to drugs. It also allows […]

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Tags: cancer research, Farhad Kosari, genomics, George Vasmatzis, Panos Anastasiadis, University of Illinois Urbana-Champaign


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