Advancing the Science

Mayo Clinic Medical Science Blog – an eclectic collection of research- and research education-related stories: feature stories, mini news bites, learning opportunities, profiles and more from Mayo Clinic.

Items Tagged ‘basic science’

February 12, 2021

Body fat investigation provides insights for ‘obesity paradox’

By Elizabeth Zimmermann Elizabeth Zimmermann

The Obesity Paradox Excerpted from a 2009 Mayo Clinic Proceedings article, The Obesity Paradox: Perception vs Knowledge. “Data from several epidemiological studies, including the Framingham Heart Study, have found a positive relationship between obesity and mortality, in particular cardiovascular mortality. However, several cross-sectional, retrospective database studies … have found an inverse correlation between body mass […]

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Tags: animal model, basic science, biomedical research, discovery research, gastroenterology, molecular biology, obesity, pancreatitis, Vijay Singh


January 27, 2021

Mitochondria vs. Alzheimer’s

By Advancing the Science contributor Advancing the Science contributor

Targeting mitochondria is a promising therapeutic strategy, study shows “Mitochondria are the powerhouses of the cell.” Many a young science student has heard that truism. “Mitochondria are extremely important because they ensure that we have energy supply for cells to conduct functions,” says Mayo Clinic researcher Eugenia Trushina, Ph.D. “Otherwise, we would all be dead […]

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Tags: Alzheimer's disease, animal model, basic science, clinical trials, discovery research, drug discovery, Eugenia Trushina, Kogod Center on Aging, Minnesota Partnership, mitochondria, National Cancer Institute, National Institutes of Health


September 17, 2020

Could regenerative medicine hold a key to understanding Alzheimer’s disease?

By Susan Buckles Susan Buckles

September is World Alzheimer’s Month, a time to raise awareness of research to unlock scientific mysteries around a disease that robs people of their memory, independence and ultimately their ability to think and reason. Focused on disease causes and cures, the Center for Regenerative Medicine is driving innovation as a collaborative partner in Mayo Clinic’s […]

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Tags: Alzheimer's disease, basic science, Center for Regenerative Medicine, dementia, discovery research, Guojun Bu, Melissa Murray, neurology, neurosciences, stem cells


August 7, 2020

Research News Roundup — July 2020

By Elizabeth Zimmermann Elizabeth Zimmermann

It sometimes seems that summer has flown by without any significant achievements, and only incremental evidence building in the topic of the moment. COVID-19 has had a major dampening effect on social interaction, one doesn’t need to be a researcher to figure that out. However, biomedical and health care delivery research have not paused for […]

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Tags: antibodies, bacteriophages, basic science, blood clots, CAR-T, COVID-19, discovery research, immunity, non-Hodgkin lymphoma, phage, prosthesis, Research News Roundup


August 6, 2020

Calcium Signaling in Microglia: Implications for Brain Diseases?

By Sara Tiner Sara Tiner

Calcium helps nerves and muscles “fire,” signaling cells to do something like contract a muscle or release a neurotransmitter in the brain. But in one type of brain cell, microglia, this calcium signaling seemed absent. Researchers have long wondered why microglia don’t seem to rely on calcium signaling and now, with a recent publication in […]

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Tags: animal model, Anthony Umpierre, basic science, calcium, cell signaling, discovery research, Gregory Worrell, Long-Jun Wu, neurology, neurosciences, Yanlu Ying


April 23, 2020

Antimalarials, COVID-19, cardiac arrest

By Elizabeth Zimmermann Elizabeth Zimmermann

Over the last few weeks, chloroquine and hydroxychloroquine have become household words. These antiparasitic drugs normally prescribed for malaria were introduced early in the rush to find potential treatments for COVID-19. As time goes on, the public discussion has centered on who should get these particular drugs and when. Meanwhile many doctors and medical researchers […]

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Tags: basic science, COVID-19, discovery research, Michael Ackerman


April 20, 2020

Mayo Clinic Research in the news: Week in review 4/20/2020

By Elizabeth Zimmermann Elizabeth Zimmermann

Many of us have passed another week of “stay at home” but others are on the front lines of patient care and COVID-19 research. How does it spread? Why do some people contract more serious cases, or develop more antibodies? How many people have been exposed? These are just a few of the questions Mayo […]

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Tags: Andrew Badley, antibodies, basic science, biomedical research, cardiology, Colin West, COVID-19, Department of Laboratory Medicine and Pathology, Elitza Theel, Gregory Poland, immune system, immunity


April 16, 2020

Mayo Clinic research discovers how stem cells repair damage from heart attacks

By Susan Buckles Susan Buckles

Mayo Clinic researchers have uncovered stem cell-activated mechanisms of healing after a heart attack. Stem cells restored cardiac muscle back to its condition before the heart attack, in turn providing a blueprint of how stem cells may work. The study, published in NPJ Regenerative Medicine, finds that human cardiopoietic cells zero in on damaged proteins to reverse […]

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Tags: Andre Terzic, basic science, cardiac regeneration, cardiovascular disease, Center for Regenerative Medicine, discovery research, heart attack, heart failure, Kent Arrell, mesenchymal stem cells, stem cells


March 17, 2020

Regenerating missing bacteria for healthier lungs

By Jennifer Schutz Jennifer Schutz

Connection to COVID-19 People with COPD are at a greater risk of contracting COVID-19, and likely to experience much worse cases than people with healthy lungs. To help alleviate concerns, the COPD Foundation has set up a continuous blog with expert answers to questions related to COPD. In addition, the Centers for Disease Control and […]

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Tags: basic science, Center for Regenerative Medicine, COPD, COVID-19, discovery research, lung disease, Regenerative Medicine Minnesota, Veena Taneja


February 3, 2020

Merging minds to accelerate research discovery

By Advancing the Science contributor Advancing the Science contributor

Mayo Clinic and Arizona State University formed the Mayo Clinic and Arizona State University Alliance for Health Care in 2010 to merge minds and accelerate research discoveries, improve patient care through innovation and transform medical education to enhance health outcomes. Highlights of two of the joint research efforts follow. Identifying a blood-based biomarker for early-stage […]

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Tags: Alzheimer's disease, Arizona State University, basic science, biomarkers, Charles Adler, infectious disease, Michael Sierks, MRSA, Parkinson's disease, Robin Patel


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