Items Tagged ‘basic science’
September 22, 2022
A preclinical step toward treating chronic dry mouth
Mayo Clinic researchers replicated chronic dry mouth from radiation damage in preclinical models, laying the foundation for stem cell research to regenerate salivary tissue after cancer. This discovery uses targeted X-radiation to mimic human injury and establish a lab model for testing cellular therapies for dry mouth. The study is published in Radiation Research. “The […]
Tags: basic science, Center for Regenerative Medicine, discovery research, dry mouth, head and neck cancer, Jeffrey Janus, medical research, Nagarajan Kannan, otolaryngology, quality of life, radiation therapy, salivary glands
November 10, 2021
Mayo researchers link gut microbiome to rheumatoid arthritis prognosis
By Susan Murphy 
A significant indicator of whether a patient with rheumatoid arthritis will improve over the course of disease may lie in part in their gut, according to new research from Mayo Clinic’s Center for Individualized Medicine. The study, published in Genome Medicine, found that predicting a patient’s future rheumatoid arthritis prognosis could be possible by zeroing in […]
Tags: arthritis, basic science, Center for Individualized Medicine, genomics, gut health, Jaeyun Sung, John Davis III, medical research, microbiome, rheumatology
September 28, 2021
By Advancing the Science contributor
Andrew Limper, M.D., was the first named associate dean of Practice Transformation, in the Mayo Clinic Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery. During his tenure with the center, and through his leadership, Mayo Clinic streamlined practice transformative research and discovery efforts across the institution into a single, […]
Tags: Andrew Limper, artificial intelligence, basic science, Ben Pollock, biostatistics, cardiology, Center for Clinical and Translational Science, Center for the Science of Health Care Delivery, clinical trials, Curt Storlie, discovery research, electrocardiogram
May 20, 2021
Diagnostic test — Matthew Binnicker, Ph.D., reflects on a lab in a pressure cooker
By Advancing the Science contributor
Matthew Binnicker, Ph.D., director of the Clinical Virology Laboratory in the Division of Clinical Microbiology at Mayo Clinic in Rochester, has been involved in his fair share of viral outbreaks. He led a team that worked to develop a test for the Zika virus outbreak in 2016. He was involved in planning for patients during […]
Tags: basic science, biomedical research, collaboration, COVID-19, Department of Laboratory Medicine and Pathology, discovery research, Matthew Binnicker, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic Laboratories, virology
March 1, 2021
Mayo Clinic Research in the news — 3/1/2021
Media coverage of Mayo Clinic research and expertise covered home cancer screening tests, youth vaping, several advancements in women’s health, COVID-19 and many other topics. Read on for excerpts and links to the articles. Health officials: “Youth vaping a serious issue” KAAL, 2/25/2021 New findings show youth vaping in Minnesota is worse than many had […]
Tags: addiction research, Alzheimer's disease, Aminah Jatoi, anaphylaxis, arthritis, basic science, bladder cancer, BRCA1, BRCA2, cancer screening, clinical research, cognitive impairment
February 12, 2021
Body fat investigation provides insights for ‘obesity paradox’
The Obesity Paradox Excerpted from a 2009 Mayo Clinic Proceedings article, The Obesity Paradox: Perception vs Knowledge. “Data from several epidemiological studies, including the Framingham Heart Study, have found a positive relationship between obesity and mortality, in particular cardiovascular mortality. However, several cross-sectional, retrospective database studies … have found an inverse correlation between body mass […]
Tags: animal model, basic science, biomedical research, discovery research, gastroenterology, molecular biology, obesity, pancreatitis, Vijay Singh, visceral fat
January 27, 2021
By Advancing the Science contributor
Targeting mitochondria is a promising therapeutic strategy, study shows “Mitochondria are the powerhouses of the cell.” Many a young science student has heard that truism. “Mitochondria are extremely important because they ensure that we have energy supply for cells to conduct functions,” says Mayo Clinic researcher Eugenia Trushina, Ph.D. “Otherwise, we would all be dead […]
Tags: Alzheimer's disease, animal model, basic science, clinical trials, discovery research, drug discovery, Eugenia Trushina, Kogod Center on Aging, Minnesota Partnership, mitochondria, National Cancer Institute, National Institutes of Health
September 17, 2020
Could regenerative medicine hold a key to understanding Alzheimer’s disease?
September is World Alzheimer’s Month, a time to raise awareness of research to unlock scientific mysteries around a disease that robs people of their memory, independence and ultimately their ability to think and reason. Focused on disease causes and cures, the Center for Regenerative Medicine is driving innovation as a collaborative partner in Mayo Clinic’s […]
Tags: Alzheimer's disease, basic science, Center for Regenerative Medicine, dementia, discovery research, Guojun Bu, Melissa Murray, neurology, neurosciences, stem cells
August 7, 2020
Research News Roundup — July 2020
It sometimes seems that summer has flown by without any significant achievements, and only incremental evidence building in the topic of the moment. COVID-19 has had a major dampening effect on social interaction, one doesn’t need to be a researcher to figure that out. However, biomedical and health care delivery research have not paused for […]
Tags: antibodies, bacteriophages, basic science, blood clots, CAR-T cell therapy, COVID-19, discovery research, immunity, non-Hodgkin lymphoma, phage, prosthesis, Research News Roundup
August 6, 2020
Calcium Signaling in Microglia: Implications for Brain Diseases?
By Sara Tiner 
Calcium helps nerves and muscles “fire,” signaling cells to do something like contract a muscle or release a neurotransmitter in the brain. But in one type of brain cell, microglia, this calcium signaling seemed absent. Researchers have long wondered why microglia don’t seem to rely on calcium signaling and now, with a recent publication in […]
Tags: animal model, Anthony Umpierre, basic science, cell signaling, discovery research, Gregory Worrell, Long-Jun Wu, neurology, neurosciences, Yanlu Ying