Advancing the Science

Mayo Clinic Medical Science Blog – an eclectic collection of research- and research education-related stories: feature stories, mini news bites, learning opportunities, profiles and more from Mayo Clinic.

Items Tagged ‘cancer genomics’

January 19, 2022

Mayo Clinic researchers discover biomarker for predicting immunotherapy response in mesothelioma cancer

By Susan Murphy Susan Murphy (@susanmurphy)

Immunotherapy has given some patients a better outcome with mesothelioma, an aggressive cancer in the lining around the lungs that has been linked to asbestos exposure. The individualized therapy can stimulate the body’s immune system to attack cancer cells and prolong life. But it doesn’t always work, and some patients experience significant side effects.  Now, Mayo Clinic Center for Individualized Medicine researchers may […]

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Tags: Aaron Mansfield, cancer genomics, cancer research, Center for Individualized Medicine, genomics, mesothelioma


July 14, 2021

New Mayo study validates melanoma test to help some patients avoid surgical biopsy

By Susan Murphy Susan Murphy (@susanmurphy)

More than 100,00 people in the U.S. are expected to be diagnosed with melanoma this year — double the number of cases compared to 30 years ago, according to the American Academy of Dermatology Association.  “Melanoma accounts for only about 2% of skin cancers, but it causes a majority of skin cancer deaths,” says Alexander Meves, M.D., a Mayo […]

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Tags: Alexander Meves, cancer, cancer genomics, Center for Individualized Medicine, melanoma, precision medicine


June 29, 2021

Gene fusion discovery in ultrarare tumor highlights potential therapeutic target

By Susan Murphy Susan Murphy (@susanmurphy)

A scientific investigation led by a team of researchers from Mayo Clinic’s Center for Individualized Medicine reveals that an ultrarare cancer called epithelioid trophoblastic tumor (ETT), which can develop in the uterus after conception, recurrently exhibits an abnormal fusion of two genes. This fusion creates an unusual protein that triggers aggressive cell growth — the […]

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Tags: cancer genomics, Center for Individualized Medicine, precision medicine, rare disease, uterine cancer


January 25, 2021

Mayo Clinic Research in the news — 1/25/2021

By Elizabeth Zimmermann Elizabeth Zimmermann (@elizabethzimmermann)

From acupuncture, breast cancer, diabetes, euthyroid … all the way to Zika, Mayo Clinic research and experts are featured in the news. Also find COVID-19 observations, advice and findings. The Rochester Epidemiology Project: “The greatest medical resource you’ve never heard of” Rochester Magazine, 1/22/2021 The Rochester Epidemiology Project has changed the way we view ADHD. […]

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Tags: acupuncture, acute flaccid myelitis, ADHD, Alzheimer's disease, amyloidosis, artificial intelligence, biomarkers, breast cancer, Brent Bauer, cancer, cancer genomics, cannabidiol (CBD)


December 2, 2020

Conquering cancer by targeting its genetic abnormalities

By Susan Murphy Susan Murphy (@susanmurphy)

Joanne Garnett has harrowing memories of that life-changing day back in 1981. She was a 39-year-old land use planner living in Wyoming when she received a call from her doctor confirming she had uterine cancer.  “I was shocked, and it was strange because I didn’t fit any profile for uterine cancer,” Garnett recalls. “I got a […]

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Tags: BRCA2, breast cancer, cancer genomics, Center for Individualized Medicine, clinical research, DNA, gene mutation, genetic testing, hereditary cancer, Lynch syndrome, Mayo Clinic Cancer Center, Niloy "Jewel" Samadder


November 18, 2020

Mayo Clinic study finds 1 in 8 patients with cancer harbor inherited genetic mutations

By Susan Murphy Susan Murphy (@susanmurphy)

Genetic testing can uncover inherited genetic mutations, and could individualize cancer therapies, improve survival, manage cancer in loved ones and push the boundaries of precision medicine. In a new study published in JAMA Oncology, scientists with Mayo Clinic’s Center for Individualized Medicine conducted genetic testing in more than 3,000 patients who were diagnosed with cancer at Mayo Clinic Cancer Center locations […]

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Tags: cancer genomics, genetic testing


October 29, 2020

Developing solutions for early detection of pancreatic cancer

By Advancing the Science contributor Advancing the Science contributor (@advancingthescience)

By Lisa Newkirk Pancreatic cancer is one of the deadliest forms of cancer, but patients who are diagnosed at an early stage can survive five years or longer. A team at Mayo Clinic is developing patient-centered solutions for early detection of pancreatic cancer using artificial intelligence and biomarkers. This year, over 57,000 Americans will be […]

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Tags: artificial intelligence, biomarkers, cancer genomics, cancer screening, collaboration, CT, DNA, Gloria Petersen, Mayo Clinic Cancer Center, pancreatic cancer, patient experience, Shounak Majumder


August 20, 2020

Could population genetic screening improve public health?

By Colette Gallagher Colette Gallagher (@colettegallagher)

Hereditary BRCA-related breast and ovarian cancer, Lynch syndrome and familial hypercholesterolemia are estimated to be relatively prevalent in the general population but poorly found using traditional risk screening. In a typical medical practice, genetic testing for these conditions is based on personal or family history, ethnic background or other demographic characteristics, that may not always […]

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Tags: breast cancer, cancer genomics, Center for Individualized Medicine, genetic testing, genetics, hereditary cancer, hereditary diseases, Lynch syndrome, Matthew Ferber, ovarian cancer, population health


May 1, 2020

Non-COVID research in the news, 5/1/2020

By Advancing the Science contributor Advancing the Science contributor (@advancingthescience)

Although the week’s coverage has largely consisted of COVID-19 news, closer inspection finds it peppered with Mayo Clinic research on some other topics. We’ve collected a few of the news clips for ease of review. Read on for findings in cancer, deep vein thrombosis and Alzheimer’s disease: cfDNA Assay Shows Predictive Value in Detecting Cancer, […]

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Tags: Alzheimer's disease, cancer, cancer genomics, David Thiel, deep vein thrombosis, DNA, Guojun Bu, News of the Week, Rosa Rademakers


February 18, 2020

Mayo researchers studying ‘promising’ new approach to treating advanced cancer, 1 patient at a time, 1 tumor at a time

By Susan Murphy Susan Murphy (@susanmurphy)

A collaborative team of Mayo Clinic scientists is studying an innovative strategy for treating advanced cancer, using genomics and human tumor samples as their guide. The novel approach, called Ex Vivo, creates a miniature cancer replica for testing therapies outside a patient’s body, combined with a comprehensive genomic analysis of a patient’s cancer cells. “We […]

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Tags: biomarkers, cancer, cancer genomics, Center for Individualized Medicine, genomics, George Vasmatzis, individualized medicine, Mayo Clinic Cancer Center, Minetta Liu, Panos Anastasiadis, personalized medicine


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