Advancing the Science

Mayo Clinic Medical Science Blog – an eclectic collection of research- and research education-related stories: feature stories, mini news bites, learning opportunities, profiles and more from Mayo Clinic.

Items Tagged ‘CAR-T cell therapy’

September 27, 2022

Physician-scientist investigates dual CAR-T cell therapy for multiple myeloma cancer

By Susan Murphy Susan Murphy (@susanmurphy)

Leo Sakemura, M.D., Ph.D., a physician-scientist in Mayo Clinic’s Division of Hematology, is working to advance immunotherapy efficacy in multiple myeloma by uncovering treatment resistance mechanisms and developing a more potent immunotherapy approach. His strategy focuses on simultaneously targeting cancer cells and the ecosystem surrounding each tumor, known as the tumor microenvironment.  Dr. Sakemura’s previous […]

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Tags: cancer genomics, cancer research, CAR-T cell therapy, Center for Individualized Medicine, hematology, immunotherapy, Leo Sakemura, metabolomics, multiple myeloma


August 30, 2022

Biomanufacturing 101: Understanding a new era of therapeutics

By Susan Buckles Susan Buckles (@susanbuckles)

Advancing discoveries such as cellular therapies from clinical trials to commercial therapy is a cornerstone of Mayo Clinic’s strategic emphasis on biomanufacturing. The long-term vision is to provide new cures for patients with unmet needs. “Biomanufacturing is a type of manufacturing that utilizes sources from the human body — cells, blood, enzymes, tissues, genes or […]

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Tags: biologics, biomanufacturing, CAR-T cell therapy, Center for Regenerative Medicine, Julie Allickson, regnerative biotherapeutics


August 2, 2022

Addressing the challenges of chimeric antigen receptor-T cell therapy

By Advancing the Science contributor Advancing the Science contributor (@advancingthescience)

Article by Marla Broadfoot Chimeric antigen receptor-T cell therapy (CAR-T cell therapy) — a type of immunotherapy that reprograms a patient’s T cells to recognize and destroy cancer cells — has revolutionized the treatment of blood cancers. While the technique has successfully sent patients with advanced disease into remission, it is far from perfect. CAR-T […]

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Tags: cancer therapy, CAR-T cell therapy, Center for Regenerative Medicine, Hong Qin, regenerative immunotherapy, Saad Kenderian


June 15, 2022

Research News Roundup — May 2022

By Advancing the Science contributor Advancing the Science contributor (@advancingthescience)

In May, researchers from Mayo Clinic reported gains in understanding of the benefit of AI-enabled ECGs, including from wearable devices. They made strides towards more effective treatment of non-Hodgkin lymphoma and nonmetastatic gastroesophageal cancer. And in news many people can use, investigators report on the results of a survey linked to the Mayo Clinic Diet. […]

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Tags: AFib, artificial intelligence, atrial fibrillation, CAR-T cell therapy, Center for the Science of Health Care Delivery, clinical trials, cognitive impairment, EKG, electrocardiogram, esophageal cancer, gastric cancer, gastroesophageal cancer


May 3, 2022

Research News Roundup — April 2022

By Advancing the Science contributor Advancing the Science contributor (@advancingthescience)

At Mayo Clinic, biomedical, clinical and health care delivery research are ongoing. The evidence gathered by Mayo researchers, and other scientists, is used to ensure that patients receive the highest quality of care and achieve the best possible outcomes. Advancing the Science’s Research News Roundup excerpts research-related news releases published in the last month. Read […]

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Tags: biomarkers, brain, cancer, cancer prevention, CAR-T cell therapy, Center for Individualized Medicine, clinical trials, colorectal cancer, dementia, diversity, health equity, kidney transplant


April 11, 2022

Unleashing the body’s ability to heal

By Susan Buckles Susan Buckles (@susanbuckles)

“We are the patient’s last, best hope,” has been the motto of the Immune, Progenitor and Cell Therapeutics lab, also known as the IMPACT lab, at Mayo Clinic. This lab specializes in clinical and investigative use of cells as living drugs within the body to fight disease and initiate healing when standard therapies don’t work. […]

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Tags: Allan Dietz, CAR-T cell therapy, cellular therapy, Center for Regenerative Medicine, clinical trials, Dennis Gastineau, Franklyn Prendergast, mesenchymal stem cells, perianal fistula, Stanimar Vuk-Pavlovic


February 28, 2022

Preparing to deliver next-generation therapeutics

By Susan Buckles Susan Buckles (@susanbuckles)

Mayo Clinic is among the academic medical centers on the cusp of biomanufacturing next-generation cell and gene therapies that offer hope of new cures for rare and complex diseases. Biomanufacturing this new era of biologic medicines is much different than manufacturing pharmaceuticals from complex molecules. It requires highly specialized lab infrastructure, new processes and new […]

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Tags: Allan Dietz, biomedical engineering, CAR-T cell therapy, Center for Regenerative Medicine, clinical trials, Michael Gustafson, personalized medicine


February 15, 2022

Advancing a new era of regenerative medicine

By Susan Buckles Susan Buckles (@susanbuckles)

Allegorically speaking, if Mayo Clinic were a garden and regenerative technologies were fruits and vegetables, William Faubion Jr., M.D., sees himself as a gardener tending to the teams responsible for these new healing therapies. Dr. Faubion, who is the newly named associate medical director for Mayo Clinic’s Center for Regenerative Medicine, wants to advance discoveries […]

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Tags: Allan Dietz, biomedical engineering, CAR-T cell therapy, Center for Regenerative Medicine, Crohn's disease, Eric Dozois, gastroenterology, immune system, inflammatory bowel disease, perianal fistula, regenerative medicine research, surgery


September 2, 2021

Understanding the inner workings of CAR-T therapy

By Susan Buckles Susan Buckles (@susanbuckles)

Mayo Clinic researchers have biomanufactured chimeric antigen receptor-T cell therapy  (CAR-T cell therapy) in a new way to track the cells’ cancer fighting journey and predict toxic side effects. This Mayo Clinic breakthrough, published in Cancer Immunology Research, also could unravel the mystery of how to unleash CAR-T cell therapy to destroy solid tumors. “This […]

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Tags: CAR-T cell therapy, Center for Individualized Medicine, Center for Regenerative Medicine, chimeric antigen receptor therapy, clinical research, clinical trials, hematology, immunotherapy, Kah Whye Peng, Reona Sakemura, Saad Kenderian, Stephen Russell


February 22, 2021

Mayo Clinic Research in the news — 2/22/2021

By Elizabeth Zimmermann Elizabeth Zimmermann (@elizabethzimmermann)

Over the last week, Mayo Clinic researchers and expertise have been cited in wide range of news stories, from the ever present COVID-19 to telehealth, participation in cancer clinical trials, creatine supplements, artificial intelligence and more. Read on for headlines, excerpts and links. Telehealth research & key resources: Research findings American Medical Association, 2/19/2021 Telehealth […]

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Tags: Andrew Jagim, angioplasty, artificial intelligence, Bernard Gersh, blood pressure, Brian Pickering, cancer, CAR-T cell therapy, cardiology, cardiovascular medicine, clinical trials, COVID-19


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