Items Tagged ‘CAR-T cell therapy’
September 27, 2022
Physician-scientist investigates dual CAR-T cell therapy for multiple myeloma cancer
By Susan Murphy 
Leo Sakemura, M.D., Ph.D., a physician-scientist in Mayo Clinic’s Division of Hematology, is working to advance immunotherapy efficacy in multiple myeloma by uncovering treatment resistance mechanisms and developing a more potent immunotherapy approach. His strategy focuses on simultaneously targeting cancer cells and the ecosystem surrounding each tumor, known as the tumor microenvironment. Dr. Sakemura’s previous […]
Tags: cancer genomics, cancer research, CAR-T cell therapy, Center for Individualized Medicine, hematology, immunotherapy, Leo Sakemura, metabolomics, multiple myeloma
August 30, 2022
Biomanufacturing 101: Understanding a new era of therapeutics
Advancing discoveries such as cellular therapies from clinical trials to commercial therapy is a cornerstone of Mayo Clinic’s strategic emphasis on biomanufacturing. The long-term vision is to provide new cures for patients with unmet needs. “Biomanufacturing is a type of manufacturing that utilizes sources from the human body — cells, blood, enzymes, tissues, genes or […]
Tags: biologics, biomanufacturing, CAR-T cell therapy, Center for Regenerative Medicine, Julie Allickson, regnerative biotherapeutics
August 2, 2022
Addressing the challenges of chimeric antigen receptor-T cell therapy
By Advancing the Science contributor
Article by Marla Broadfoot Chimeric antigen receptor-T cell therapy (CAR-T cell therapy) — a type of immunotherapy that reprograms a patient’s T cells to recognize and destroy cancer cells — has revolutionized the treatment of blood cancers. While the technique has successfully sent patients with advanced disease into remission, it is far from perfect. CAR-T […]
Tags: cancer therapy, CAR-T cell therapy, Center for Regenerative Medicine, Hong Qin, regenerative immunotherapy, Saad Kenderian
June 15, 2022
Research News Roundup — May 2022
By Advancing the Science contributor
In May, researchers from Mayo Clinic reported gains in understanding of the benefit of AI-enabled ECGs, including from wearable devices. They made strides towards more effective treatment of non-Hodgkin lymphoma and nonmetastatic gastroesophageal cancer. And in news many people can use, investigators report on the results of a survey linked to the Mayo Clinic Diet. […]
Tags: AFib, artificial intelligence, atrial fibrillation, CAR-T cell therapy, Center for the Science of Health Care Delivery, clinical trials, cognitive impairment, EKG, electrocardiogram, esophageal cancer, gastric cancer, gastroesophageal cancer
May 3, 2022
Research News Roundup — April 2022
By Advancing the Science contributor
At Mayo Clinic, biomedical, clinical and health care delivery research are ongoing. The evidence gathered by Mayo researchers, and other scientists, is used to ensure that patients receive the highest quality of care and achieve the best possible outcomes. Advancing the Science’s Research News Roundup excerpts research-related news releases published in the last month. Read […]
Tags: biomarkers, brain, cancer, cancer prevention, CAR-T cell therapy, Center for Individualized Medicine, clinical trials, colorectal cancer, dementia, diversity, health equity, kidney transplant
April 11, 2022
Unleashing the body’s ability to heal
“We are the patient’s last, best hope,” has been the motto of the Immune, Progenitor and Cell Therapeutics lab, also known as the IMPACT lab, at Mayo Clinic. This lab specializes in clinical and investigative use of cells as living drugs within the body to fight disease and initiate healing when standard therapies don’t work. […]
Tags: Allan Dietz, CAR-T cell therapy, cellular therapy, Center for Regenerative Medicine, clinical trials, Dennis Gastineau, Franklyn Prendergast, mesenchymal stem cells, perianal fistula, Stanimar Vuk-Pavlovic
February 28, 2022
Preparing to deliver next-generation therapeutics
Mayo Clinic is among the academic medical centers on the cusp of biomanufacturing next-generation cell and gene therapies that offer hope of new cures for rare and complex diseases. Biomanufacturing this new era of biologic medicines is much different than manufacturing pharmaceuticals from complex molecules. It requires highly specialized lab infrastructure, new processes and new […]
Tags: Allan Dietz, biomedical engineering, CAR-T cell therapy, Center for Regenerative Medicine, clinical trials, Michael Gustafson, personalized medicine
February 15, 2022
Advancing a new era of regenerative medicine
Allegorically speaking, if Mayo Clinic were a garden and regenerative technologies were fruits and vegetables, William Faubion Jr., M.D., sees himself as a gardener tending to the teams responsible for these new healing therapies. Dr. Faubion, who is the newly named associate medical director for Mayo Clinic’s Center for Regenerative Medicine, wants to advance discoveries […]
Tags: Allan Dietz, biomedical engineering, CAR-T cell therapy, Center for Regenerative Medicine, Crohn's disease, Eric Dozois, gastroenterology, immune system, inflammatory bowel disease, perianal fistula, regenerative medicine research, surgery
September 2, 2021
Understanding the inner workings of CAR-T therapy
Mayo Clinic researchers have biomanufactured chimeric antigen receptor-T cell therapy (CAR-T cell therapy) in a new way to track the cells’ cancer fighting journey and predict toxic side effects. This Mayo Clinic breakthrough, published in Cancer Immunology Research, also could unravel the mystery of how to unleash CAR-T cell therapy to destroy solid tumors. “This […]
Tags: CAR-T cell therapy, Center for Individualized Medicine, Center for Regenerative Medicine, chimeric antigen receptor therapy, clinical research, clinical trials, hematology, immunotherapy, Kah Whye Peng, Reona Sakemura, Saad Kenderian, Stephen Russell
February 22, 2021
Mayo Clinic Research in the news — 2/22/2021
Over the last week, Mayo Clinic researchers and expertise have been cited in wide range of news stories, from the ever present COVID-19 to telehealth, participation in cancer clinical trials, creatine supplements, artificial intelligence and more. Read on for headlines, excerpts and links. Telehealth research & key resources: Research findings American Medical Association, 2/19/2021 Telehealth […]
Tags: Andrew Jagim, angioplasty, artificial intelligence, Bernard Gersh, blood pressure, Brian Pickering, cancer, CAR-T cell therapy, cardiology, cardiovascular medicine, clinical trials, COVID-19