Advancing the Science

Mayo Clinic Medical Science Blog – an eclectic collection of research- and research education-related stories: feature stories, mini news bites, learning opportunities, profiles and more from Mayo Clinic.

Items Tagged ‘Center for Regenerative Medicine’

September 22, 2022

A preclinical step toward treating chronic dry mouth

By Susan Buckles Susan Buckles (@susanbuckles)

Mayo Clinic researchers replicated chronic dry mouth from radiation damage in preclinical models, laying the foundation for stem cell research to regenerate salivary tissue after cancer. This discovery uses targeted X-radiation to mimic human injury and establish a lab model for testing cellular therapies for dry mouth. The study is published in Radiation Research. “The […]

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Tags: basic science, Center for Regenerative Medicine, discovery research, dry mouth, head and neck cancer, Jeffrey Janus, medical research, Nagarajan Kannan, otolaryngology, quality of life, radiation therapy, salivary glands


August 30, 2022

Biomanufacturing 101: Understanding a new era of therapeutics

By Susan Buckles Susan Buckles (@susanbuckles)

Advancing discoveries such as cellular therapies from clinical trials to commercial therapy is a cornerstone of Mayo Clinic’s strategic emphasis on biomanufacturing. The long-term vision is to provide new cures for patients with unmet needs. “Biomanufacturing is a type of manufacturing that utilizes sources from the human body — cells, blood, enzymes, tissues, genes or […]

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Tags: biologics, biomanufacturing, CAR-T cell therapy, Center for Regenerative Medicine, Julie Allickson, regnerative biotherapeutics


August 16, 2022

Addressing diversity barriers to regenerative medicine

By Susan Buckles Susan Buckles (@susanbuckles)

With the promise of regenerative medicine comes the risk of widening health care disparities. Sometimes the newest discoveries, such as regenerative interventions, are out of reach for people in diverse ethnic or socioeconomic groups — or they may not understand or trust new options for healing. Mayo Clinic is trying to overcome those barriers by […]

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Tags: biomedical ethics, Center for Regenerative Medicine, clinical trials, diversity, equity and inclusion, Jorge Mallea, Zubin Master


August 2, 2022

Addressing the challenges of chimeric antigen receptor-T cell therapy

By Advancing the Science contributor Advancing the Science contributor (@advancingthescience)

Article by Marla Broadfoot Chimeric antigen receptor-T cell therapy (CAR-T cell therapy) — a type of immunotherapy that reprograms a patient’s T cells to recognize and destroy cancer cells — has revolutionized the treatment of blood cancers. While the technique has successfully sent patients with advanced disease into remission, it is far from perfect. CAR-T […]

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Tags: cancer therapy, CAR-T cell therapy, Center for Regenerative Medicine, Hong Qin, regenerative immunotherapy, Saad Kenderian


July 28, 2022

Bringing regenerative technology of the future to patients today

By Susan Buckles Susan Buckles (@susanbuckles)

“The sky’s the limit,” “possibility” and “potential cure for disease” are aspirational ways Mayo Clinic physicians and scientists described regenerative medicine in a recent virtual presentation at the World Stem Cell Summit 2022. Mayo’s panel discussion showcased how it is advancing regenerative medicine through industry collaborations that accelerate scientific discoveries to early stage clinical trials. […]

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Tags: 3D printing, Abba Zubair, biomanufacturing, Center for Regenerative Medicine, David Lott, Julie Allickson, Saranya Wyles, tissue engineering, World Stem Cell Summit


July 19, 2022

Molecular mapping of the heart to predict disease susceptibility

By Susan Buckles Susan Buckles (@susanbuckles)

Vulnerability to heart disease can be projected before symptoms occur, Mayo Clinic discovered in preclinical research. This proof-of-concept study revealed that heart muscle changes indicate who is vulnerable to disease later in life. These changes can be detected from blood samples through comprehensive protein and metabolite profiling. This exploratory mapping, conducted in the Marriott Family […]

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Tags: Andre Terzic, cardiac regeneration, Center for Regenerative Medicine, heart disease, Kent Arrell, Marriott Family Comprehensive Cardiac Regenerative Program, multiomics, Satsuki Yamada


July 5, 2022

Training the next generation in regenerative medicine

By Susan Buckles Susan Buckles (@susanbuckles)

Mayo Clinic is welcoming a new class of five students into the Regenerative Sciences track within the doctoral program in Mayo Clinic’s Graduate School of Biomedical Sciences, one of the first programs of its kind. Training the next generation of physicians and scientists to research, develop and deliver new biotherapies is critical to advancing the […]

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Tags: Aubrey Berger, Center for Regenerative Medicine, Isobel Scarisbrick, Jimmy Cai, Kyle Knofczynski, Mayo Clinic Graduate School of Biomedical Sciences, Rafaela Simoes Torigoe, regenerative medicine education, Regenerative Sciencs Ph.D. track, Tiana Salomon


June 21, 2022

What’s behind patient requests for stem cells?

By Susan Buckles Susan Buckles (@susanbuckles)

In one of the first studies of its kind, Mayo Clinic analyzed a large group of patients to understand their motivations for seeking stem cell therapies and whether expectations are grounded in science. The findings could help health care professionals cut through misleading claims and better counsel patients. This research by Jennifer Arthurs; Zubin Master, […]

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Tags: biomedical ethics, Center for Regenerative Medicine, clinical research, Jennifer Arthurs, orthopedics, Shane Shapiro, stem cells, Zubin Master


June 7, 2022

Students embrace teaching to advance regenerative medicine

By Susan Buckles Susan Buckles (@susanbuckles)

A group of Mayo Clinic students is going beyond their rigorous research schedules to help up-and-comers and established health care professionals alike learn about the emerging practice of regenerative medicine. As teaching assistants for Mayo Clinic’s Regenerative Medicine and Surgery “selectives,” they are channeling their enthusiasm for this new area of practice into weeklong courses […]

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Tags: Armin Garmany, Center for Regenerative Medicine, Connor Lentz, Eric Grewal, Saranya Wyles


May 23, 2022

Saranya Wyles: Regenerating damaged skin

By Susan Buckles Susan Buckles (@susanbuckles)

When she was just 8 years old, Saranya Wyles, M.D., Ph.D., would recite the stages of wound healing in Latin terms — rubor, tumor, calor, dolor and functio laesa— to her father at the dinner table. Decades later, that ingrained knowledge would be a cornerstone of her regenerative medicine research, education and practice at Mayo […]

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Tags: Center for Regenerative Medicine, dermatology, education, Saranya Wyles, senescent cells, skin regeneration, wound healing, zombie cells


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