Advancing the Science

Mayo Clinic Medical Science Blog – an eclectic collection of research- and research education-related stories: feature stories, mini news bites, learning opportunities, profiles and more from Mayo Clinic.

Items Tagged ‘clinical trials’

January 2, 2019

Toward clinical trials for one type of ALS

By Kate Ledger k8ledger

When a team of Mayo Clinic researchers discovered in 2011 the genetic repeat mutation known as c9orf72, the finding shed new light on amyotrophic lateral sclerosis (ALS). The mutation, which occurs as a short sequence of code repeated hundreds to thousands of times in the gene, is now known to appear in 40 percent of […]

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Tags: ALS, amyotrophic lateral sclerosis, Björn Oskarsson, clinical trials, Dennis Dickson, Kevin Boylan, Leonard Petrucelli, Lou Gehrig's disease, neurology, neurosciences, Rosa Rademakers, Tania Gendron


December 13, 2018

The sky’s the limit

By Advancing the Science contributor advancingthescience

In 2011, Jared Ausnehmer left his local hospital carrying the weight of an oxygen tank and the worry of what might come next. At age 21, he’d already defied the odds for those born with hypoplastic left heart syndrome, a birth defect in which the left side of the heart is underdeveloped or nonexistent. With […]

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Tags: Andre Terzic, cardiology, Center for Regenerative Medicine, clinical trials, HLHS, hypoplastic left heart syndrome


November 5, 2018

Early-phase Cancer Clinical Trials (Phase I) Available at Mayo Clinic

By Nicole Brudos Ferrara nicoleferrara

The Early Cancer Therapeutics Group at Mayo Clinic offers patients whose cancers haven’t responded to standard chemotherapy or other treatments the opportunity to join an early-phase clinical trial of a potential new treatment. Early-phase clinical trials (phase I) determine safe dosage levels and safe methods of treatment delivery. A phase I clinical trial might be […]

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Tags: cancer, clinical trials, Mayo Clinic Cancer Center


September 11, 2018

Meet Katrina Croghan, Clinical Research Coordinator

By Advancing the Science contributor advancingthescience

Katrina Croghan is clinical research coordinator for Mayo Clinic Cancer Center, assigned to the division of Hematology in Rochester, Minnesota. She began her career in ecology and animal science, but while en route to a related Ph.D., ended up as a supplemental research coordinator because of her knowledge of writing protocols and conducting research. She says: “For a short […]

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Tags: clinical trials, hematology, Katrina Croghan


August 6, 2018

Regenerative medicine in novel fetal therapy program

By Jennifer Schutz jenniferschutz

A life-saving procedure improves fetal lung health and reduces post-natal complications Specialists at Mayo Clinic are pioneering a life-saving procedure as part of a clinical trial for babies with congenital diaphragmatic hernia (CDH). When a baby’s lungs are not adequately developed at birth, severe complications and even death can result. Waiting for the baby to be […]

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Tags: Center for Regenerative Medicine, clinical trials, Denise Klinker, maternal and fetal medicine, Mayo Clinic Proceedings, regenerative medicine, Regenerative Medicine Minnesota, Rodrigo Ruano


July 25, 2018

Advances in lung cancer immunotherapy and management of immune-mediated adverse events

By Advancing the Science contributor advancingthescience

Over the last few years, immunotherapy using immune checkpoint inhibitors targeting programmed cell death receptor 1 (PD-1) or programmed cell death receptor ligand 1 (PD-L1) has revolutionized the therapeutic approach to advanced-stage non-small cell lung cancer and numerous other malignancies. Monotherapy, using the anti-PD-1 antibody pembrolizumab, is now Food and Drug Administration (FDA) approved for […]

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Tags: clinical trials, immunotherapy, lung cancer, Mayo Clinic Cancer Center, measles virus


July 9, 2018

Offering underserved groups access to cutting-edge research

By Kris Schanilec kschanilec

For many patients, clinical trials offer a chance to benefit from promising new treatments that are not available in the doctor’s office. Yet not all people have the same access to these opportunities. Groups such as racial minorities, older individuals, and those with low income are less likely than others to participate in clinical trials, […]

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Tags: biobank, blood cancer, Carmen Radecki Breitkopf, clinical trials, community engagement, Gerardo Colon-Otero, health disparities, hematology, HPV, lymphoma


June 14, 2018

Bridging the gap: Introducing the health care of tomorrow

By Jennifer Schutz jenniferschutz

Forward-thinking leadership, unparalleled expertise and a commitment to solving unmet patient needs allow Mayo Clinic to bridge the gap between the delivery of traditional health care today and the rapid advancement of revolutionary care in the near future. Increasing Translational Capabilities Traditionally, it could take years for physician-scientists to develop the essential expertise to create […]

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Tags: Center for Regenerative Medicine, clinical trials, Mayo Clinic Graduate School of Biomedical Sciences, regenerative medicine, research education, stem cells


June 13, 2018

Following grant renewal, CCaTS abuzz with activity

By Caitlin Doran caityrosey

In October 2017, the National Institutes of Health (NIH) renewed Mayo Clinic’s Clinical and Translational Science Award from the National Center for Advancing Translational Sciences—an award totaling $48.8 million over five years. This renewal allows Mayo Clinic to continue pursuing its long-term goals in clinical and translational science, while also setting new short term objectives. […]

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Tags: Adil Bharucha, Amanda Leightner, Andrew Badley, Center for Clinical and Translational Science, clinical trials, David Warner, education, Stephen Ekker, Sundeep Khosla, zebrafish


June 12, 2018

New collaboration to develop and test decisions for AFib patients

By Elizabeth Zimmermann elizabethzimmermann

The Patient-Centered Outcomes Research Institute (PCORI) and American Heart Association (AHA) announced today that it is establishing  AHA-PCORI Decision-making and Choices to Inform Dialogue and Empower AFib patients (DECIDE) Center. The DECIDE Center will be a collaboration between the University of Utah (where it will be based) and Mayo Clinic. The team has three projects: Identify […]

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Tags: Center for the Science of Health Care Delivery, clinical trials, education, PCORI, Peter Noseworthy


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