Advancing the Science

Mayo Clinic Medical Science Blog – an eclectic collection of research- and research education-related stories: feature stories, mini news bites, learning opportunities, profiles and more from Mayo Clinic.

Items Tagged ‘discovery research’

May 20, 2021 · Leave a Comment

Diagnostic test — Matthew Binnicker, Ph.D., reflects on a lab in a pressure cooker

By Advancing the Science contributor Advancing the Science contributor (@advancingthescience)

Matthew Binnicker, Ph.D., director of the Clinical Virology Laboratory in the Division of Clinical Microbiology at Mayo Clinic in Rochester, has been involved in his fair share of viral outbreaks. He led a team that worked to develop a test for the Zika virus outbreak in 2016. He was involved in planning for patients during […]

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Tags: basic science, biomedical research, collaboration, COVID-19, Department of Laboratory Medicine and Pathology, discovery research, Matthew Binnicker, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic Laboratories, virology


February 12, 2021 · Leave a Comment

Body fat investigation provides insights for ‘obesity paradox’

By Elizabeth Zimmermann Elizabeth Zimmermann (@elizabethzimmermann)

The Obesity Paradox Excerpted from a 2009 Mayo Clinic Proceedings article, The Obesity Paradox: Perception vs Knowledge. “Data from several epidemiological studies, including the Framingham Heart Study, have found a positive relationship between obesity and mortality, in particular cardiovascular mortality. However, several cross-sectional, retrospective database studies … have found an inverse correlation between body mass […]

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Tags: animal model, basic science, biomedical research, discovery research, gastroenterology, molecular biology, obesity, pancreatitis, Vijay Singh


January 27, 2021 · Leave a Comment

Mitochondria vs. Alzheimer’s

By Advancing the Science contributor Advancing the Science contributor (@advancingthescience)

Targeting mitochondria is a promising therapeutic strategy, study shows “Mitochondria are the powerhouses of the cell.” Many a young science student has heard that truism. “Mitochondria are extremely important because they ensure that we have energy supply for cells to conduct functions,” says Mayo Clinic researcher Eugenia Trushina, Ph.D. “Otherwise, we would all be dead […]

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Tags: Alzheimer's disease, animal model, basic science, clinical trials, discovery research, drug discovery, Eugenia Trushina, Kogod Center on Aging, Minnesota Partnership, mitochondria, National Cancer Institute, National Institutes of Health


January 5, 2021 · Leave a Comment

Looking back on 2020: A successful year of research at Mayo Clinic in Florida

By Advancing the Science contributor Advancing the Science contributor (@advancingthescience)

At Mayo Clinic, Research and Education provide the basis for all we are able to do for patients today. Furthermore, they enable practice transformation as we seek to meet future patient needs. From new capabilities in cell therapy and immunotherapy, to advances in neurodegenerative diseases and studies of the virus that causes COVID-19, research at Mayo Clinic continued […]

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Tags: Alzheimer's disease, Ben Pollock, biomanufacturing, biomarkers, biostatistics, brain, cancer, CAR-T, carbon ion therapy, Center for Regenerative Medicine, chemotherapy, clinical research


September 17, 2020 · Leave a Comment

Could regenerative medicine hold a key to understanding Alzheimer’s disease?

By Susan Buckles Susan Buckles (@susanbuckles)

September is World Alzheimer’s Month, a time to raise awareness of research to unlock scientific mysteries around a disease that robs people of their memory, independence and ultimately their ability to think and reason. Focused on disease causes and cures, the Center for Regenerative Medicine is driving innovation as a collaborative partner in Mayo Clinic’s […]

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Tags: Alzheimer's disease, basic science, Center for Regenerative Medicine, dementia, discovery research, Guojun Bu, Melissa Murray, neurology, neurosciences, stem cells


August 7, 2020 · Leave a Comment

Research News Roundup — July 2020

By Elizabeth Zimmermann Elizabeth Zimmermann (@elizabethzimmermann)

It sometimes seems that summer has flown by without any significant achievements, and only incremental evidence building in the topic of the moment. COVID-19 has had a major dampening effect on social interaction, one doesn’t need to be a researcher to figure that out. However, biomedical and health care delivery research have not paused for […]

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Tags: antibodies, bacteriophages, basic science, blood clots, CAR-T, COVID-19, discovery research, immunity, non-Hodgkin lymphoma, phage, prosthesis, Research News Roundup


August 6, 2020 · Leave a Comment

Calcium Signaling in Microglia: Implications for Brain Diseases?

By Sara Tiner Sara Tiner (@saratiner)

Calcium helps nerves and muscles “fire,” signaling cells to do something like contract a muscle or release a neurotransmitter in the brain. But in one type of brain cell, microglia, this calcium signaling seemed absent. Researchers have long wondered why microglia don’t seem to rely on calcium signaling and now, with a recent publication in […]

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Tags: animal model, Anthony Umpierre, basic science, cell signaling, discovery research, Gregory Worrell, Long-Jun Wu, neurology, neurosciences, Yanlu Ying


June 23, 2020 · Leave a Comment

Harnessing the body’s ability to heal

By Susan Buckles Susan Buckles (@susanbuckles)

Researchers at Mayo Clinic are studying ways to engineer human-like tissue to bolster the body’s ability to heal itself. Scientists in the Regenerative Medicine Biomaterials and Biomolecules Lab have engineered biomaterials that could regenerate tissue capable of restoring injured nerves and bones. They’ve discovered that biomaterials derived from polymers are biodegradable. When used along with […]

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Tags: biomedical engineering, bone regeneration, Center for Regenerative Medicine, discovery research, Lichun Lu, neuroregeneration, tissue engineering, Xifeng Liu


April 23, 2020 · Leave a Comment

Antimalarials, COVID-19, cardiac arrest

By Elizabeth Zimmermann Elizabeth Zimmermann (@elizabethzimmermann)

Over the last few weeks, chloroquine and hydroxychloroquine have become household words. These antiparasitic drugs normally prescribed for malaria were introduced early in the rush to find potential treatments for COVID-19. As time goes on, the public discussion has centered on who should get these particular drugs and when. Meanwhile many doctors and medical researchers […]

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Tags: basic science, COVID-19, discovery research, Michael Ackerman


April 16, 2020 · Leave a Comment

Mayo Clinic research discovers how stem cells repair damage from heart attacks

By Susan Buckles Susan Buckles (@susanbuckles)

Mayo Clinic researchers have uncovered stem cell-activated mechanisms of healing after a heart attack. Stem cells restored cardiac muscle back to its condition before the heart attack, in turn providing a blueprint of how stem cells may work. The study, published in NPJ Regenerative Medicine, finds that human cardiopoietic cells zero in on damaged proteins to reverse […]

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Tags: Andre Terzic, basic science, cardiac regeneration, cardiovascular disease, Center for Regenerative Medicine, discovery research, heart attack, heart failure, Kent Arrell, mesenchymal stem cells, stem cells


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