Items Tagged ‘discovery research’
September 22, 2022
A preclinical step toward treating chronic dry mouth
Mayo Clinic researchers replicated chronic dry mouth from radiation damage in preclinical models, laying the foundation for stem cell research to regenerate salivary tissue after cancer. This discovery uses targeted X-radiation to mimic human injury and establish a lab model for testing cellular therapies for dry mouth. The study is published in Radiation Research. “The […]
Tags: basic science, Center for Regenerative Medicine, discovery research, dry mouth, head and neck cancer, Jeffrey Janus, medical research, Nagarajan Kannan, otolaryngology, quality of life, radiation therapy, salivary glands
April 4, 2022
Research News Roundup — March 2022
By Advancing the Science contributor 
March news reports are often focused on college basketball, daylight savings time and Mardi Gras. This year, Ukraine and the its people are top of mind for many, providing a sobering counterpoint. Behind the scenes, research has continued at Mayo Clinic, and several findings were released in March that help build the evidence and point […]
Tags: aging, Alzheimer's disease, animal model, artificial intelligence, biomarkers, chemotherapy, collaboration, COVID-19, depression, discovery research, drug discovery, genomics
September 28, 2021
By Advancing the Science contributor
Andrew Limper, M.D., was the first named associate dean of Practice Transformation, in the Mayo Clinic Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery. During his tenure with the center, and through his leadership, Mayo Clinic streamlined practice transformative research and discovery efforts across the institution into a single, […]
Tags: Andrew Limper, artificial intelligence, basic science, Ben Pollock, biostatistics, cardiology, Center for Clinical and Translational Science, Center for the Science of Health Care Delivery, clinical trials, Curt Storlie, discovery research, electrocardiogram
May 20, 2021
Diagnostic test — Matthew Binnicker, Ph.D., reflects on a lab in a pressure cooker
By Advancing the Science contributor
Matthew Binnicker, Ph.D., director of the Clinical Virology Laboratory in the Division of Clinical Microbiology at Mayo Clinic in Rochester, has been involved in his fair share of viral outbreaks. He led a team that worked to develop a test for the Zika virus outbreak in 2016. He was involved in planning for patients during […]
Tags: basic science, biomedical research, collaboration, COVID-19, Department of Laboratory Medicine and Pathology, discovery research, Matthew Binnicker, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic Laboratories, virology
February 12, 2021
Body fat investigation provides insights for ‘obesity paradox’
The Obesity Paradox Excerpted from a 2009 Mayo Clinic Proceedings article, The Obesity Paradox: Perception vs Knowledge. “Data from several epidemiological studies, including the Framingham Heart Study, have found a positive relationship between obesity and mortality, in particular cardiovascular mortality. However, several cross-sectional, retrospective database studies … have found an inverse correlation between body mass […]
Tags: animal model, basic science, biomedical research, discovery research, gastroenterology, molecular biology, obesity, pancreatitis, Vijay Singh, visceral fat
January 27, 2021
By Advancing the Science contributor
Targeting mitochondria is a promising therapeutic strategy, study shows “Mitochondria are the powerhouses of the cell.” Many a young science student has heard that truism. “Mitochondria are extremely important because they ensure that we have energy supply for cells to conduct functions,” says Mayo Clinic researcher Eugenia Trushina, Ph.D. “Otherwise, we would all be dead […]
Tags: Alzheimer's disease, animal model, basic science, clinical trials, discovery research, drug discovery, Eugenia Trushina, Kogod Center on Aging, Minnesota Partnership, mitochondria, National Cancer Institute, National Institutes of Health
January 5, 2021
Looking back on 2020: A successful year of research at Mayo Clinic in Florida
By Advancing the Science contributor
At Mayo Clinic, Research and Education provide the basis for all we are able to do for patients today. Furthermore, they enable practice transformation as we seek to meet future patient needs. From new capabilities in cell therapy and immunotherapy, to advances in neurodegenerative diseases and studies of the virus that causes COVID-19, research at Mayo Clinic continued […]
Tags: Alzheimer's disease, Ben Pollock, biomanufacturing, biomarkers, biostatistics, brain, cancer, CAR-T cell therapy, carbon ion therapy, Center for Regenerative Medicine, chemotherapy, clinical research
September 17, 2020
Could regenerative medicine hold a key to understanding Alzheimer’s disease?
September is World Alzheimer’s Month, a time to raise awareness of research to unlock scientific mysteries around a disease that robs people of their memory, independence and ultimately their ability to think and reason. Focused on disease causes and cures, the Center for Regenerative Medicine is driving innovation as a collaborative partner in Mayo Clinic’s […]
Tags: Alzheimer's disease, basic science, Center for Regenerative Medicine, dementia, discovery research, Guojun Bu, Melissa Murray, neurology, neurosciences, stem cells
August 7, 2020
Research News Roundup — July 2020
It sometimes seems that summer has flown by without any significant achievements, and only incremental evidence building in the topic of the moment. COVID-19 has had a major dampening effect on social interaction, one doesn’t need to be a researcher to figure that out. However, biomedical and health care delivery research have not paused for […]
Tags: antibodies, bacteriophages, basic science, blood clots, CAR-T cell therapy, COVID-19, discovery research, immunity, non-Hodgkin lymphoma, phage, prosthesis, Research News Roundup
August 6, 2020
Calcium Signaling in Microglia: Implications for Brain Diseases?
By Sara Tiner 
Calcium helps nerves and muscles “fire,” signaling cells to do something like contract a muscle or release a neurotransmitter in the brain. But in one type of brain cell, microglia, this calcium signaling seemed absent. Researchers have long wondered why microglia don’t seem to rely on calcium signaling and now, with a recent publication in […]
Tags: animal model, Anthony Umpierre, basic science, cell signaling, discovery research, Gregory Worrell, Long-Jun Wu, neurology, neurosciences, Yanlu Ying