Advancing the Science

Mayo Clinic Medical Science Blog – an eclectic collection of research- and research education-related stories: feature stories, mini news bites, learning opportunities, profiles and more from Mayo Clinic.

Items Tagged ‘DNA’

September 11, 2019

Targeting therapy to each patient’s unique cancer

By Advancing the Science contributor advancingthescience

Article by Sara Damore As DNA sequencing technology helps bring genetic factors driving disease into focus, researchers have developed new cancer therapies to target a patient’s unique cancer, especially for those who do not respond to standard therapy. Funda Meric-Bernstam, M.D., a physician-scientist at MD Anderson Cancer Center, will speak on Decision Support  for Precision […]

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Tags: Alan Bryce, cancer, Center for Individualized Medicine, CIMCon19, clinical trials, DNA, genomics, hematology, Mayo Clinic Cancer Center, oncology, personalized medicine


June 5, 2019

Mayo Clinic at ASCO 2019

By Elizabeth Zimmermann elizabethzimmermann

Every year the American Society of Clinical Oncology (ASCO) hosts a gathering of cancer researchers and clinicians from around the world to teach and learn from each other, sharing their research and innovations in patient care. ASCO’s mission is “conquering cancer through research education, and promotion of the highest quality patient care” – a theme […]

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Tags: bias, cancer, cancer prevention, CAR-T, clinical trials, colorectal cancer, DNA, genetics, Hao Xie, hematology, Katharine Price, Mayo Clinic Cancer Center


March 28, 2019

When the shoelaces fray: short telomere syndromes

By Advancing the Science contributor advancingthescience

Article by Barbara Toman Unlike gray hair, one of the most significant signs of aging is invisible to the naked eye. Deep inside cells, at the tips of thread-like chromosomes, structures known as telomeres protect chromosomes from deterioration—a bit like the way caps at the ends of shoelaces prevent fraying. Telomeres naturally shorten as people […]

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Tags: Center for Individualized Medicine, DNA, genetics, Mrinal Patnaik, short telomere syndrome


February 12, 2019

Mayo Clinic discovery advances potential individualized treatment for mesothelioma

By Susan Buckles susanbuckles

Large chromosomal rearrangements present in mesothelioma could make it possible to understand which patients are likely respond to immunotherapy,  researchers at the Mayo Clinic Center for Individualized Medicine  have discovered. The research is published in the Journal of Thoracic Oncology. “What we’ve shown so far is that these large complex chromosomal rearrangements are frequent in […]

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Tags: Aaron Mansfield, basic science, cancer, Center for Individualized Medicine, DNA, genomics, George Vasmatzis, immunology, Mayo Clinic Cancer Center, mesothelioma


October 1, 2018

How Bread Yeast and Book Damage Help Clarify Epigenetics

By Sara Tiner saratiner

Genes don’t change, but how they are used by the body can.  That shift in use (which is called epigenetics) can mean the difference between illness and health. To better understand how that happens Mayo researchers are examining how genes are activated (used) and copied. With a recent publication in the journal Science, a team […]

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Tags: basic science, Center for Individualized Medicine, Chuanhe Yu, DNA, epigenetics


August 2, 2018

Research News Roundup-July 2018

By Elizabeth Zimmermann elizabethzimmermann

The Mayo Clinic Research News Roundup includes brief summaries and links to research-related news releases from the past month. It also connects readers to associated resources. Read on for more information from Mayo Clinic Research. Anesthesia, surgery linked to subtle decline in memory and thinking in older adults, Mayo study finds In adults over 70, exposure to general […]

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Tags: aging, Alzheimer's disease, basic science, DNA, genomics, Mayo Clinic Proceedings, Mayo Clinic Study of Aging, neurology, ovarian cancer, precision medicine, Research News Roundup


July 5, 2018

Research News Roundup-June 2018

By Elizabeth Zimmermann elizabethzimmermann

Each month, we publish Mayo Clinic’s Research News Roundup. This article includes brief summaries and links to news releases from the preceding month that discuss some of our latest medical research. It also connects readers to related resources. This month’s Roundup includes a number of findings related pancreatic cancer and other gastrointestinal disorders, as well […]

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Tags: basic science, cancer, Center for Individualized Medicine, constipation, diabetes, DNA, DNA testing, gastroenterology, gene mutation, genetic testing, liver cancer, pancreatic cancer


June 25, 2018

Targeted DNA next-generation sequencing aids the molecular assessment of pancreatic neuroendocrine tumors

By Nicole Brudos Ferrara nicoleferrara

Pancreas neuroendocrine tumors (pNETs) are a collection of rare neoplasms distinct from pancreas ductal adenocarcinoma. Although the molecular profile of pNETs is somewhat unclear, advances in molecular tumor genotyping is one area of research that is advancing the understanding of this disease. In a 2017 article published in Oncotarget, Ferga Gleeson, M.D., M.B., B.Ch., a specialist […]

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Tags: basic science, Center for Individualized Medicine, DNA, Ferga Gleeson, gastroenterology, individualized medicine, pancreatic cancer, precision medicine


April 2, 2018

Mayo scientists discover missing link in DNA damage repair

By bobnellis bobnellis

For years, researchers have known that our genome is protected by a system of detection, evaluation and repair processes that activate any time DNA damage occurs. Upon detection, the damage is assessed, repaired in one way or another, or, if it can’t be repaired the cell is cued to self-destruct. Much of that effort is […]

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Tags: basic science, cancer, DNA, Mayo Clinic Cancer Center, Zhenkun Lou


March 22, 2018

Mayo researchers identify characteristics of colon polyps most likely to progress to cancer

By Nicole Brudos Ferrara nicoleferrara

Researchers at Mayo Clinic are closer to answering the question, why does one colon polyp transform to cancer while another seemingly identical polyp does not? A colon polyp is a small clump of cells that forms on the lining of the colon. While most colon polyps are harmless some can develop into colon cancer, which […]

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Tags: biobank, cancer, colon cancer, DNA, Lisa Boardman, Mayo Clinic Cancer Center


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