Advancing the Science

Mayo Clinic Medical Science Blog – an eclectic collection of research- and research education-related stories: feature stories, mini news bites, learning opportunities, profiles and more from Mayo Clinic.

Items Tagged ‘genomics’

August 25, 2021 · Leave a Comment

Mayo Clinic analysis shows how disease, diet, and genomics interact with gut virome

By Colette Gallagher Colette Gallagher (@colettegallagher)

Mayo Clinic researchers published a comprehensive analysis of the gut virome in Gastroenterology, showing how disease, diet and genomics interact with the gut virome in irritable bowel syndrome. This common disorder affects the intestine and manifests as abdominal pain associated with constipation, diarrhea or both. The gut virome is one component of the microbiome (bacteria, fungi, viruses). […]

View full entry Comment on this

Tags: Center for Individualized Medicine, DNA, genomics, microbiome, Purna Kashyap


August 4, 2021 · Leave a Comment

Researchers review how sex steroids change gut, vaginal microbiome

By Colette Gallagher Colette Gallagher (@colettegallagher)

It is well-established that the human body’s microbiome ― the bacteria in the gut ― dramatically affects health and disease. However, the role of the gut in women’s health outcomes is largely unknown. Mayo Clinic and Wellesley College researchers focused on how the interactions of steroids on gut and vaginal microbiomes influence women’s health outcomes […]

View full entry Comment on this

Tags: Center for Individualized Medicine, genomics, Marina Walther-Antonio, microbiome


July 21, 2021 · Leave a Comment

Mayo researchers develop algorithm to predict rheumatoid arthritis disease activity

By Susan Murphy Susan Murphy (@susanmurphy)

Researchers within Mayo Clinic’s Center for Individualized Medicine and Division of Rheumatology have developed a first-of-its-kind machine learning algorithm that can predict rheumatoid arthritis disease activity in a patient. The algorithm analyzes biochemical metabolites ― the product of the body’s metabolism ― in blood. “Having fast, reliable and scalable measures for predicting the clinical course of disease […]

View full entry Comment on this

Tags: arthritis, artificial intelligence, autoimmune disorder, biomarkers, Center for Individualized Medicine, clinical research, genomics, Jaeyun Sung, John Davis III, metabolism, metabolomics, rheumatology


July 20, 2021 · Leave a Comment

Newly discovered genetic variants in a single gene cause neurodevelopmental disorder, Mayo study finds

By Susan Murphy Susan Murphy (@susanmurphy)

Rochester, Minn. — Mayo Clinic researchers have discovered that genetic variants in a neuro-associated gene called SPTBN1 are responsible for causing a neurodevelopmental disorder. The study, published in Nature Genetics, is a first step in finding a potential therapeutic strategy for this disorder, and it increases the number of genes known to be associated with conditions that affect […]

View full entry Comment on this

Tags: Center for Individualized Medicine, gene mutation, genetics, genomics, Margot Cousin, neurosciences


July 14, 2021 · Leave a Comment

Mayo Clinic research in the news — 7/12/2021

By Advancing the Science contributor Advancing the Science contributor (@advancingthescience)

Research and expertise from Mayo Clinic have been in the news on topics from marijuana, sleep, disparities, dementia and doses of vaccine. Read more. New York Times, Can Marijuana Make You a Better Athlete?  … “If you look at any test of physical performance, there’s either no data, it’s a wash, or marijuana makes it worse,” […]

View full entry Comment on this

Tags: addiction research, alcoholism, Alejandro Rabinstein, Alyx Porter, Alzheimer's disease, artificial intelligence, autoimmune disorder, Bhanu Kolla, breast cancer, cancer vaccine, cardiology, Center for Individualized Medicine


June 8, 2021 · Leave a Comment

Mayo researchers articulate implications of Omic-Medicine Era – What needs to happen with each stakeholder?

By Colette Gallagher Colette Gallagher (@colettegallagher)

In the near future, genome sequencing, among other biological measures, will be as routine as X-rays and cholesterol testing. The challenge, though, will be accurately interpreting the vast amount of data and effectively using it to guide decisions about health care. In a position statement published in Hepatology, Mayo Clinic researchers layout perspectives of various stakeholders […]

View full entry Comment on this

Tags: Arjun Athreya, artificial intelligence, big data, bioethics, Center for Individualized Medicine, data science, genetic testing, genetics, genomics, Konstantinos Lazaridis, patient experience, population health


June 2, 2021 · Leave a Comment

Researchers develop new technique to study ‘microcancers’ and screen cancer-fighting drugs

By Advancing the Science contributor Advancing the Science contributor (@advancingthescience)

A team from the University of Illinois Urbana-Champaign’s Grainger College of Engineering and Mayo Clinic have developed a new technique for creating “microcancer” cell cultures. It allows researchers to form hundreds of microcancers in a high-throughput format using a small, microfabricated chip, enabling direct measurement of cell health or response to drugs. It also allows […]

View full entry Comment on this

Tags: cancer research, Farhad Kosari, genomics, George Vasmatzis, Panos Anastasiadis, University of Illinois Urbana-Champaign


April 22, 2021 · Leave a Comment

Mayo researchers reveal gene therapy path for treating children with rare, fatal genetic disease

By Susan Murphy Susan Murphy (@susanmurphy)

A gene therapy strategy developed by Mayo Clinic researchers could offer a potential treatment for a rare and fatal genetic disease that often sickens babies in their first days of life. The disease, propionic acidemia, occurs in 1 in 100,000 live births in the U.S. There is no cure. “As soon as the babies start […]

View full entry Comment on this

Tags: Center for Individualized Medicine, gene therapy, genomics, precision medicine, rare disease


April 20, 2021 · Leave a Comment

Mayo researchers use AI to reveal causes of complex diseases

By Susan Murphy Susan Murphy (@susanmurphy)

Researchers within Mayo Clinic’s Center for Individualized Medicine have developed an artificial intelligence (AI) platform that can uncover causal drivers and relationships embedded within complex biomedical data. Nicholas Chia, Ph.D., I. John Kalantari, Ph.D., and Kia Khezeli, Ph.D., recently tested their machine-learning framework, called Causal Relation and Inference Search Platform (CRISP) on multiomic colorectal cancer samples […]

View full entry Comment on this

Tags: artificial intelligence, cancer, Center for Individualized Medicine, colorectal cancer, data science, genomics, I. John Kalantari, Kia Khezeli, microbiome, NASA, Nicholas Chia, rare disease


March 31, 2021 · Leave a Comment

Mayo Clinic researchers explore personalized approach to anti-obesity medications

By Colette Gallagher Colette Gallagher (@colettegallagher)

Individualized medicine initiatives mainly focus on rare diseases or cancer. Little has been attempted to individualize treatment for noncommunicable chronic diseases such as obesity — a chronic, relapsing disease, and a primary cause of Type 2 diabetes, fatty liver disease, cardiovascular disease and cancer. There are many obesity interventions, such as diets, devices, surgery and […]

View full entry Comment on this

Tags: Andres Acosta, Center for Individualized Medicine, genome, genomics, obesity, personalized medicine


Contact Us · Privacy Policy