Advancing the Science

Mayo Clinic Medical Science Blog – an eclectic collection of research- and research education-related stories: feature stories, mini news bites, learning opportunities, profiles and more from Mayo Clinic.

Items Tagged ‘Center for Individualized Medicine’

January 10, 2019

Gene therapy: potential and pitfalls

By Susan Buckles susanbuckles

Research is advancing gene therapy as a possible treatment or eventual cure for genetic diseases that bedevil modern science. Gene therapy was conceived over 20 years ago, and until recently, remained largely in the research lab. But gene therapy products are now beginning to be approved by the U.S. Food and Drug Administration for clinical […]

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Tags: Center for Individualized Medicine, David Deyle, gene mutation, gene therapy, Saad Kenderian


December 20, 2018

Discovery advances potential individualized treatment for mesothelioma

By Susan Buckles susanbuckles

This article originally ran on the Center for Individualized Medicine blog on November 26, 2018 Large chromosomal rearrangements present in mesothelioma could make it possible to understand which patients are likely respond to immunotherapy,  researchers at the Mayo Clinic Center for Individualized Medicine  have discovered. The research is published in the Journal of Thoracic Oncology. […]

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Tags: Aaron Mansfield, cancer, Center for Individualized Medicine, George Vasmatzis, mesothelioma


December 10, 2018

Novel data-driven approach for precision medicine

By Colette Gallagher colettegallagher

Thousands of patients’ tumors have been sequenced in the past decade, yielding a rich source of data on the changes associated with the cancer development and treatment response. However, there are no validated methods that are used in the clinic to select the best therapy. Today, Mayo Clinic researchers report an omics-guided (comprehensive) drug prioritization […]

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Tags: cancer, Center for Individualized Medicine, Judy Boughey, Krishna Rani Kalari, Liewei Wang, Matthew Goetz, PANOPLY, personalized medicine, pharmacogenomics


November 29, 2018

The right diet for you… or for your gut microbes?

By Sara Tiner saratiner

This article originally appeared on the Center for Individualized Medicine blog on Oct. 10, 2018. The right diet, obesity and gut health are topics patients, clinicians and scientists wrestle with every day. We want to eat a good diet and lose weight or avoid weight gain, so our health span matches our life span. But […]

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Tags: Center for Individualized Medicine, gut health, microbiome, Purna Kashyap


November 15, 2018

Meet Lisa Schimmenti: Searching for drug therapies to treat hearing loss

By Susan Buckles susanbuckles

This article originally appeared on the Center for Individualized Medicine blog on Oct. 4, 2018 Article by Sharon Rosen   Lisa Schimmenti, M.D. has always been fascinated with Helen Keller and all she accomplished, in spite of being blind and deaf from a very young age. As the newly appointed chair of Mayo Clinic’s Department of […]

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Tags: basic science, Center for Individualized Medicine, Lisa Schimmenti, zebrafish


November 6, 2018

Mayo Clinic research combines genetics and psychiatry to seek biomarkers for precise alcohol abuse therapies

By Susan Buckles susanbuckles

This article originally appeared on the Center for Individualized Medicine blog on Oct. 23, 2018. Mayo Clinic research is bringing together knowledge of psychiatry, genetics, metabolomics, pharmacogenomics and artificial intelligence to seek biological markers associated with alcohol use disorder and treatment response. Finding the molecular drivers of alcohol use disorder commonly known as alcoholism, could […]

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Tags: Center for Individualized Medicine, Mark Frye, pharmacogenomics, Richard Weinshilboum


October 24, 2018

Bringing pharmacogenomics to your medical practice

By Susan Buckles susanbuckles

After decades of research, pharmacogenomics is “ready for prime time” so to speak. Mayo clinic is a leader in moving pharmacogenomics into clinical care — with the goal of helping providers identify medications that are compatible with their patients’ genetic profiles. Drugs and Genes: Pharmacogenomics for the Modern Health Care Team 2018 is an opportunity […]

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Tags: cardiology, Center for Individualized Medicine, Fadi Shamoun, pharmacogenomics


October 22, 2018

Personalized screening: finding and treating breast cancer sooner

By Susan Buckles susanbuckles

This article originally appeared on the Center for Individualized Medicine blog on Oct. 15, 2018. Article by Sharon Rosen October is Breast Cancer Awareness Month, a time to reflect on new, individualized approaches to detecting and treating a cancer that affects 1 in 8 American women. Deborah Rhodes, M.D. and her Mayo Clinic colleagues are […]

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Tags: breast cancer, Carrie Hruska, Center for Individualized Medicine, Deborah Rhodes, Mayo Clinic Cancer Center, Michael O'Connor, Myra Wick


October 18, 2018

What is the impact on health care of genome editing?

By Colette Gallagher colettegallagher

Although Mayo Clinic does not use genome editing as part of any treatment in the medical practice, genome editing has promise for treating and even curing previously intractable disorders, such as Duchenne muscular dystrophy. Genome editing, via methods like CRISPR-Cas9 (clustered regularly interspaced short palindromic repeats and CRISPR-associated protein) can be used to facilitate the […]

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Tags: Center for Individualized Medicine, CRISPR, gene therapy, genome, Individualizing Medicine Conference, Megan Allyse


October 1, 2018

How Bread Yeast and Book Damage Help Clarify Epigenetics

By Sara Tiner saratiner

Genes don’t change, but how they are used by the body can.  That shift in use (which is called epigenetics) can mean the difference between illness and health. To better understand how that happens Mayo researchers are examining how genes are activated (used) and copied. With a recent publication in the journal Science, a team […]

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Tags: Center for Individualized Medicine, Chuanhe Yu, DNA, epigenetics


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