Advancing the Science

Mayo Clinic Medical Science Blog – an eclectic collection of research- and research education-related stories: feature stories, mini news bites, learning opportunities, profiles and more from Mayo Clinic.

Items Tagged ‘Center for Individualized Medicine’

September 16, 2020

Mayo Clinic research advances diagnostics to lead COVID-19 pandemic response

By Susan Murphy Susan Murphy

When COVID-19 spread across the U.S. in early March, Mayo Clinic’s Advanced Diagnostic Laboratory (ADL) urgently responded. Lab spaces were transitioned, staff reassigned and funding approvals were fast-tracked. Its goals were to accelerate research, development, translation and implementation of novel tests in order to discover life-saving treatments and diagnostics. “ADL houses a lab structure for […]

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Tags: Ann Moyer, antibodies, Benjamin Kipp, Bobbie Pritt, Center for Individualized Medicine, COVID-19, Department of Laboratory Medicine and Pathology, Dietrich Matern, Elitza Theel, genetics, genomics, John Mills


September 3, 2020

Largest pharmacogenetics clinical trial in cardiology shows potential benefit in individualized approach to anti-platelet therapy

By Advancing the Science contributor Advancing the Science contributor

Heart patients who undergo percutaneous coronary intervention (PCI) or stent placement― nonsurgical procedures to improve blood flow to the heart ― are typically prescribed anti-platelet therapy to avoid blood clots that can lead to a heart attack or stroke. New research from the international TAILOR-PCI trial, the largest pharmacogenetics clinical trial in cardiology, suggests that genetic testing could […]

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Tags: antiplatelet, cardiology, Center for Individualized Medicine, Charanjit Rihal, clinical trials, coronary artery disease, gene varient, genetics, heart disease, Kent Bailey, Michael Farkouh, Naveen Pereira


August 20, 2020

Could population genetic screening improve public health?

By Colette Gallagher Colette Gallagher

Hereditary BRCA-related breast and ovarian cancer, Lynch syndrome and familial hypercholesterolemia are estimated to be relatively prevalent in the general population but poorly found using traditional risk screening. In a typical medical practice, genetic testing for these conditions is based on personal or family history, ethnic background or other demographic characteristics, that may not always […]

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Tags: breast cancer, cancer genomics, Center for Individualized Medicine, genetic testing, genetics, hereditary cancer, hereditary diseases, Lynch syndrome, Matthew Ferber, ovarian cancer, population health


August 4, 2020

Phage therapy shows potential for treating prosthetic joint infections

By Susan Murphy Susan Murphy

Bacteriophages, or phages, may play a significant role in treating complex bacterial infections in prosthetic joints, according to new Mayo Clinic research. The findings suggest phage therapy could provide a potential treatment for managing such infections, including those involving antibiotic-resistant microbes. The research is published in the July 23 issue of Clinical Infectious Diseases (CID). “The treatment for […]

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Tags: antibacterial resistance, bacteriophages, Center for Clinical and Translational Science, Center for Individualized Medicine, collaboration, Gina Suh, infectious disease, phage, prosthesis, research, Robin Patel


May 6, 2020

Noninvasive test may help some patients with melanoma avoid lymph node biopsy

By Advancing the Science contributor Advancing the Science contributor

By Jay Furst A Mayo Clinic-led research team has developed a test for patients who have melanoma, the most serious form of skin cancer, that shows whether they’re at risk of the cancer spreading to other areas of the body. The research, described in the journal JCO Precision Oncology, could allow some patients at low […]

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Tags: Alexander Meves, cancer, Center for Individualized Medicine, Mayo Clinic Cancer Center, melanoma, research, skin cancer, Tina Hieken


April 30, 2020

Mayo researchers’ endometrial cancer discovery could lead to window of opportunity for prevention

By Susan Murphy Susan Murphy

What if a doctor could alert a woman a year or more in advance that she is likely to develop endometrial cancer? Researchers at Mayo Clinic Center for Individualized Medicine have found evidence linking functional modification of certain genes to the emergence of the disease, providing a novel opportunity for intervention and prevention. The new […]

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Tags: Andrea Mariani, biomarkers, cancer, Center for Individualized Medicine, endometrial cancer, epigenetics, gynecology, Marina Walther-Antonio, Mayo Clinic Cancer Center, microbiome, oncology, robotic technology


March 24, 2020

Individualized care for psychiatric disorders — Mayo Clinic Biobank + genetic testing could pave the way

By Susan Murphy Susan Murphy

By Sharon Rosen Patients suffering from depression, anxiety and substance use disorders often search for years to find treatment. Studies have shown that during this time gap, patients’ symptoms worsen, increasing their risk for other chronic illnesses, shortened lifespan and poor quality of life. Mayo Clinic statistical geneticist Joanna Biernacka, Ph.D. and her colleagues are working to […]

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Tags: anxiety, biobank, Center for Individualized Medicine, depression, genetic testing, genetics, Joanna Biernacka, Mark Frye, psychiatry, substance abuse disorder


March 19, 2020

Mentorship program a ‘guiding star’ for astrobiologist-turned-microbiome-researcher

By Caitlin Doran Caitlin Doran

Marina Walther-Antonio, Ph.D., came to Mayo Clinic to help start the Center for Individualized Medicine’s microbiome research program. In her previous job at NASA, she had worked with mathematicians, engineers, geologists, psychologists, and even political scientists to try to detect life in outer space. Mayo recruited her to look for “aliens”—bacteria and other organisms—living in […]

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Tags: Andrea Mariani, Bill Cliby, bioethics, Center for Clinical and Translational Science, Center for Individualized Medicine, cervical cancer, endometrial cancer, health disparities, health equity, Heidi Nelson, human papillomavirus, Jim Maher


March 10, 2020

Patient’s premature aging symptoms tied to shorter DNA strands

By Colette Gallagher Colette Gallagher

At only 27-years-old, Morgan Cook recalls the days when she had an abundant amount of energy. “I would lift weights. I would do cardio. I would – you name it, I would do it. I was a lot more active,” says Cook. “I felt like I was able to do more things with friends. I […]

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Tags: Center for Individualized Medicine, DNA, genetic counseling, genetic testing, genetics, Mrinal Patnaik, rare disease, short telomere syndrome


February 18, 2020

Mayo researchers studying ‘promising’ new approach to treating advanced cancer, 1 patient at a time, 1 tumor at a time

By Susan Murphy Susan Murphy

A collaborative team of Mayo Clinic scientists is studying an innovative strategy for treating advanced cancer, using genomics and human tumor samples as their guide. The novel approach, called Ex Vivo, creates a miniature cancer replica for testing therapies outside a patient’s body, combined with a comprehensive genomic analysis of a patient’s cancer cells. “We […]

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Tags: biomarkers, cancer, cancer genomics, Center for Individualized Medicine, genomics, George Vasmatzis, individualized medicine, Mayo Clinic Cancer Center, Minetta Liu, Panos Anastasiadis, personalized medicine


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