Items Tagged ‘Center for Individualized Medicine’
November 24, 2022
The future will be personalized: Accelerating microbiome research
By Advancing the Science contributor 
We’re in the midst of a microbiome research epidemic, according to Purna Kashyap, M.B.B.S., co-associate director of the Microbiome Program in the Mayo Clinic Center for Individualized Medicine. “We started early and are pushing hard,” says Dr. Kashyap. “We’re one of the top accelerators in the field and are well poised to move microbiome research findings to […]
Tags: arthritis, C. diff, cancer, Center for Individualized Medicine, colitis, colorectal cancer, diabetes, endometrial cancer, Francis Farraye, gastroenterology, gut health, gynecology
September 27, 2022
Physician-scientist investigates dual CAR-T cell therapy for multiple myeloma cancer
By Susan Murphy
Leo Sakemura, M.D., Ph.D., a physician-scientist in Mayo Clinic’s Division of Hematology, is working to advance immunotherapy efficacy in multiple myeloma by uncovering treatment resistance mechanisms and developing a more potent immunotherapy approach. His strategy focuses on simultaneously targeting cancer cells and the ecosystem surrounding each tumor, known as the tumor microenvironment. Dr. Sakemura’s previous […]
Tags: cancer genomics, cancer research, CAR-T cell therapy, Center for Individualized Medicine, hematology, immunotherapy, Leo Sakemura, metabolomics, multiple myeloma
September 20, 2022
Mayo Clinic researchers integrate genomics into kidney disease diagnosis, care
Genomic testing results evaluated by a team of Mayo Clinic researchers, coupled with the latest research techniques, provided a definitive diagnosis for 30.7% of families with unexplained chronic kidney disease or stones, as reported in a 2021 study published in Kidney Medicine, a Journal of the National Kidney Foundation. The study obtained the highest diagnostic yield in people with […]
Tags: Center for Individualized Medicine, genomics, kidney disease
September 13, 2022
Mayo Clinic study reveals aging speeds genomic mutations in brain
Somatic mutations naturally occur in cells throughout human development and during aging. However, it has yet to be determined whether the frequency of somatic mutations in the population are a contributing factor to the cause of neuropsychiatric disorders, cancers, and various diseases. Alexej Abyzov, Ph.D., a Mayo Clinic genomics researcher, seeks to gain a better […]
Tags: brain, Center for Individualized Medicine, genomics, neurology
September 7, 2022
Nurse-scientist investigates gut microbiome link to chemotherapy-induced nausea
By Susan Murphy
Komal Singh, Ph.D., a nurse-scientist in Mayo Clinic’s Department of Nursing is investigating individualized strategies to help mitigate symptoms of chemotherapy-induced nausea in patients receiving chemotherapy for breast cancer. Her research focuses on the complex link between nausea-related symptoms and the gut microbiome — a population of bacteria, viruses, and fungi that inhabit the gastrointestinal tract. […]
Tags: Center for Individualized Medicine, chemotherapy, microbiome, multiomics
July 20, 2022
Do environmental exposures contribute to human diseases?
By Susan Murphy
Mayo Clinic researchers put the exposome under the microscope to understand links between lifelong exposures and diseases. An accumulation of environmental chemicals, pollutants, microbes, and particulates may be living inside each of us — acquired from the air we breathe, the food we eat, products we touch, and the water we drink. These sometimes-harmful exposures […]
June 28, 2022
Mayo Clinic patient grateful after genetic test leads to unexpected, early detection of colon cancer
By Susan Murphy
Alejandro Mirazo, 56, never imagined his genetic test results would reveal a hereditary link to cancer, or that his findings would potentially save his life. He had participated in a preemptive DNA research sequencing study for Mayo Clinic’s Center for Individualized Medicine in fall 2021 solely to contribute to medical research. As a Mexican American, he also […]
Tags: Center for Individualized Medicine, colon cancer, genetic testing, genomics, Konstantinos Lazaridis, Niloy "Jewel" Samadder
June 22, 2022
Study indicates gut microbiome, host gene affect gastrointestinal disorders
In a new study published in Nature Microbiology, researchers demonstrated the power of integrating the microbiome and host gene expression data to provide insights into their combined role in gastrointestinal diseases. The microbiome consists of all microbes in the gut including bacteria, fungi, and viruses. This study focused on bacteria. “We identified a common set of […]
June 16, 2022
Native American’s genetic test results at Mayo Clinic reveal surprise lineage to ancient tribe
By Susan Murphy
Mayo Clinic working to advance health equity among Native Americans, Alaska Natives Schyler Martin, a member of the Munsee Band of Mohicans in Minnesota, was surprised and excited when his recent Mayo Clinic genetic test results revealed he has distinctive DNA lineage to an ancient group of Native Americans known as the Beringians. According to […]
Tags: Center for Individualized Medicine, DNA, genetic testing, genomics
May 31, 2022
Mayo research using DNA to catch cancer, other medical conditions earlier
What would happen if a certain percentage of serious medical conditions, including cancer diagnoses, were found significantly earlier by studying the entire genome of patients’ DNA? How would their quality of life improve, and how many fewer cancer deaths would there be each year? That’s what a group of Mayo Clinic scientists and clinicians aim […]
Tags: Bijan Borah, breast cancer, Center for Individualized Medicine, Center for the Science of Health Care Delivery, Centers for Disease Control and Prevention, DNA, genome, genomics, health disparities, hereditary cancer, hereditary diseases, hypercholesterolemia