Items Tagged ‘Center for Individualized Medicine’
September 8, 2021 · Leave a Comment
Genetic variants influence migraine treatment response, according to new Mayo study
By Susan Murphy 
Migraines affect nearly 40 million people in the U.S. Yet pinpointing an effective prophylactic medication ― the most commonly prescribed drugs for people diagnosed with migraines ― remains a long and complex process. Patients often cycle through medications for weeks or months until achieving a therapeutic response. Now after years of slow progress in migraine therapies […]
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Tags: Center for Individualized Medicine, genetics, migraine, pharmacogenomics
September 2, 2021 · Leave a Comment
Understanding the inner workings of CAR-T therapy
Mayo Clinic researchers have biomanufactured chimeric antigen receptor-T cell therapy (CAR-T cell therapy) in a new way to track the cells’ cancer fighting journey and predict toxic side effects. This Mayo Clinic breakthrough, published in Cancer Immunology Research, also could unravel the mystery of how to unleash CAR-T cell therapy to destroy solid tumors. “This […]
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Tags: CAR-T, Center for Individualized Medicine, Center for Regenerative Medicine, chimeric antigen receptor therapy, clinical research, clinical trials, hematology, immunotherapy, Kah Whye Peng, Reona Sakemura, Saad Kenderian, Stephen Russell
September 1, 2021 · Leave a Comment
Uterine microbe found to have disease-causing behavior in endometrial cancer
By Susan Murphy
A tiny microbe thriving in the uterine microbiome — a population of bacteria, viruses, yeasts/fungi in and around the uterus— could be a contributing driver of endometrial cancer, according to a new Mayo Clinic study. “We have found that a microbe that is particularly associated with endometrial cancer is capable of pathogenic behavior, and is stimulated […]
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Tags: Center for Individualized Medicine, endometrial cancer, Marina Walther-Antonio, microbiome, women's health
August 25, 2021 · Leave a Comment
Mayo Clinic analysis shows how disease, diet, and genomics interact with gut virome
Mayo Clinic researchers published a comprehensive analysis of the gut virome in Gastroenterology, showing how disease, diet and genomics interact with the gut virome in irritable bowel syndrome. This common disorder affects the intestine and manifests as abdominal pain associated with constipation, diarrhea or both. The gut virome is one component of the microbiome (bacteria, fungi, viruses). […]
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Tags: Center for Individualized Medicine, DNA, genomics, microbiome, Purna Kashyap
August 4, 2021 · Leave a Comment
Researchers review how sex steroids change gut, vaginal microbiome
It is well-established that the human body’s microbiome ― the bacteria in the gut ― dramatically affects health and disease. However, the role of the gut in women’s health outcomes is largely unknown. Mayo Clinic and Wellesley College researchers focused on how the interactions of steroids on gut and vaginal microbiomes influence women’s health outcomes […]
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Tags: Center for Individualized Medicine, genomics, Marina Walther-Antonio, microbiome
July 21, 2021 · Leave a Comment
Mayo researchers develop algorithm to predict rheumatoid arthritis disease activity
By Susan Murphy
Researchers within Mayo Clinic’s Center for Individualized Medicine and Division of Rheumatology have developed a first-of-its-kind machine learning algorithm that can predict rheumatoid arthritis disease activity in a patient. The algorithm analyzes biochemical metabolites ― the product of the body’s metabolism ― in blood. “Having fast, reliable and scalable measures for predicting the clinical course of disease […]
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Tags: arthritis, artificial intelligence, autoimmune disorder, biomarkers, Center for Individualized Medicine, clinical research, genomics, Jaeyun Sung, John Davis III, metabolism, metabolomics, rheumatology
July 20, 2021 · Leave a Comment
By Susan Murphy
Rochester, Minn. — Mayo Clinic researchers have discovered that genetic variants in a neuro-associated gene called SPTBN1 are responsible for causing a neurodevelopmental disorder. The study, published in Nature Genetics, is a first step in finding a potential therapeutic strategy for this disorder, and it increases the number of genes known to be associated with conditions that affect […]
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Tags: Center for Individualized Medicine, gene mutation, genetics, genomics, Margot Cousin, neurosciences
July 14, 2021 · Leave a Comment
Mayo Clinic research in the news — 7/12/2021
By Advancing the Science contributor
Research and expertise from Mayo Clinic have been in the news on topics from marijuana, sleep, disparities, dementia and doses of vaccine. Read more. New York Times, Can Marijuana Make You a Better Athlete? … “If you look at any test of physical performance, there’s either no data, it’s a wash, or marijuana makes it worse,” […]
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Tags: addiction research, alcoholism, Alejandro Rabinstein, Alyx Porter, Alzheimer's disease, artificial intelligence, autoimmune disorder, Bhanu Kolla, breast cancer, cancer vaccine, cardiology, Center for Individualized Medicine
July 14, 2021 · Leave a Comment
New Mayo study validates melanoma test to help some patients avoid surgical biopsy
By Susan Murphy
More than 100,00 people in the U.S. are expected to be diagnosed with melanoma this year — double the number of cases compared to 30 years ago, according to the American Academy of Dermatology Association. “Melanoma accounts for only about 2% of skin cancers, but it causes a majority of skin cancer deaths,” says Alexander Meves, M.D., a Mayo […]
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Tags: Alexander Meves, cancer, cancer genomics, Center for Individualized Medicine, melanoma, precision medicine
July 7, 2021 · Leave a Comment
Mayo researchers study genetic basis of high cholesterol in adults
In a new study published in NPJ Genomic Medicine, Mayo Clinic researchers found that genetic testing may help identify patients with high cholesterol, or hypercholesterolemia. It also may have implications for the clinical management of patients diagnosed with high cholesterol due to a genetic disorder, or familial hypercholesterolemia. “In our study, we found more than 50% of the […]
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Tags: Center for Individualized Medicine, cholesterol, genetic testing, hypercholesterolemia, Iftikhar Kullo, precision medicine