Advancing the Science

Mayo Clinic Medical Science Blog – an eclectic collection of research- and research education-related stories: feature stories, mini news bites, learning opportunities, profiles and more from Mayo Clinic.

Items Tagged ‘Center for Individualized Medicine’

October 12, 2020

States apart, two brothers’ medical mysteries solved through genetic testing

By Susan Murphy Susan Murphy

When El Paso, Texas, resident Leticia “Letty” Gutierrez met her husband David, she knew he was one in a million. The two have been married for 28 years and built a life together with three kids. Letty, a high school English teacher, says she was especially attracted to David for his wit. But a sudden […]

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Tags: ALS, amyotrophic lateral sclerosis, Center for Individualized Medicine, dementia, gene mutation, gene varient, genetic testing, hereditary diseases, medical research, Radhika Dhamija


October 6, 2020

Mayo scientists develop mathematical index to distinguish healthy microbiome from diseased

By Susan Murphy Susan Murphy

What causes some people to develop chronic diseases such as rheumatoid arthritis, cancer and metabolic syndrome while others stay healthy? A major clue could be found in their gut microbiome — the trillions of microbes living inside the digestive system that regulate various bodily functions. To utilize the huge population of tiny organisms as a […]

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Tags: Center for Individualized Medicine, genomics, gut health, Jaeyun Sung, microbiome, multiple chronic conditions


September 30, 2020

Mayo Clinic researcher finds potential target to control rare genetic disease that strikes in teen years

By Susan Murphy Susan Murphy

Patients with a rare genetic disease called familial adenomatous polyposis, (FAP), often face debilitating challenges. Typically striking in the early teenage years, FAP is characterized by hundreds to thousands of tiny polyps forming in the colon and rectum and leading to a nearly 100% percent likelihood that they will get colon cancer without a life-altering surgery […]

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Tags: cancer screening, Center for Individualized Medicine, clinical trials, colon cancer, colon polyp, colorectal cancer, gene mutation, genetic testing, hereditary diseases, Niloy "Jewel" Samadder, rare disease


September 23, 2020

Mayo researcher finds potential microbial pathway to treat IBS symptoms, lessen abdominal pain

By Susan Murphy Susan Murphy

Mayo Clinic researchers have found new evidence linking the millions of bacteria residing in our digestive systems, known as the microbiome, to a network of factors that drive irritable bowel syndrome (IBS). The findings, published in the Sept. 10, 2020, issue of Cell, raise the possibility of targeting the newly discovered microbial pathways to improve debilitating symptoms […]

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Tags: Center for Individualized Medicine, gastroenterology, gut health, irritable bowel syndrome, microbiome, Purna Kashyap


September 16, 2020

Mayo Clinic research advances diagnostics to lead COVID-19 pandemic response

By Susan Murphy Susan Murphy

When COVID-19 spread across the U.S. in early March, Mayo Clinic’s Advanced Diagnostic Laboratory (ADL) urgently responded. Lab spaces were transitioned, staff reassigned and funding approvals were fast-tracked. Its goals were to accelerate research, development, translation and implementation of novel tests in order to discover life-saving treatments and diagnostics. “ADL houses a lab structure for […]

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Tags: Ann Moyer, antibodies, Benjamin Kipp, Bobbie Pritt, Center for Individualized Medicine, COVID-19, Department of Laboratory Medicine and Pathology, Dietrich Matern, Elitza Theel, genetics, genomics, John Mills


September 3, 2020

Largest pharmacogenetics clinical trial in cardiology shows potential benefit in individualized approach to anti-platelet therapy

By Advancing the Science contributor Advancing the Science contributor

Heart patients who undergo percutaneous coronary intervention (PCI) or stent placement― nonsurgical procedures to improve blood flow to the heart ― are typically prescribed anti-platelet therapy to avoid blood clots that can lead to a heart attack or stroke. New research from the international TAILOR-PCI trial, the largest pharmacogenetics clinical trial in cardiology, suggests that genetic testing could […]

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Tags: antiplatelet, cardiology, Center for Individualized Medicine, Charanjit Rihal, clinical trials, coronary artery disease, gene varient, genetics, heart disease, Kent Bailey, Michael Farkouh, Naveen Pereira


August 20, 2020

Could population genetic screening improve public health?

By Colette Gallagher Colette Gallagher

Hereditary BRCA-related breast and ovarian cancer, Lynch syndrome and familial hypercholesterolemia are estimated to be relatively prevalent in the general population but poorly found using traditional risk screening. In a typical medical practice, genetic testing for these conditions is based on personal or family history, ethnic background or other demographic characteristics, that may not always […]

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Tags: breast cancer, cancer genomics, Center for Individualized Medicine, genetic testing, genetics, hereditary cancer, hereditary diseases, Lynch syndrome, Matthew Ferber, ovarian cancer, population health


August 4, 2020

Phage therapy shows potential for treating prosthetic joint infections

By Susan Murphy Susan Murphy

Bacteriophages, or phages, may play a significant role in treating complex bacterial infections in prosthetic joints, according to new Mayo Clinic research. The findings suggest phage therapy could provide a potential treatment for managing such infections, including those involving antibiotic-resistant microbes. The research is published in the July 23 issue of Clinical Infectious Diseases (CID). “The treatment for […]

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Tags: antibacterial resistance, bacteriophages, Center for Clinical and Translational Science, Center for Individualized Medicine, collaboration, Gina Suh, infectious disease, phage, prosthesis, research, Robin Patel


May 6, 2020

Noninvasive test may help some patients with melanoma avoid lymph node biopsy

By Advancing the Science contributor Advancing the Science contributor

By Jay Furst A Mayo Clinic-led research team has developed a test for patients who have melanoma, the most serious form of skin cancer, that shows whether they’re at risk of the cancer spreading to other areas of the body. The research, described in the journal JCO Precision Oncology, could allow some patients at low […]

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Tags: Alexander Meves, cancer, Center for Individualized Medicine, Mayo Clinic Cancer Center, melanoma, research, skin cancer, Tina Hieken


April 30, 2020

Mayo researchers’ endometrial cancer discovery could lead to window of opportunity for prevention

By Susan Murphy Susan Murphy

What if a doctor could alert a woman a year or more in advance that she is likely to develop endometrial cancer? Researchers at Mayo Clinic Center for Individualized Medicine have found evidence linking functional modification of certain genes to the emergence of the disease, providing a novel opportunity for intervention and prevention. The new […]

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Tags: Andrea Mariani, biomarkers, cancer, Center for Individualized Medicine, endometrial cancer, epigenetics, gynecology, Marina Walther-Antonio, Mayo Clinic Cancer Center, microbiome, oncology, robotic technology


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