Items Tagged ‘Center for Individualized Medicine’
January 19, 2022
By Susan Murphy 
Immunotherapy has given some patients a better outcome with mesothelioma, an aggressive cancer in the lining around the lungs that has been linked to asbestos exposure. The individualized therapy can stimulate the body’s immune system to attack cancer cells and prolong life. But it doesn’t always work, and some patients experience significant side effects. Now, Mayo Clinic Center for Individualized Medicine researchers may […]
Tags: Aaron Mansfield, cancer genomics, cancer research, Center for Individualized Medicine, genomics, mesothelioma
January 12, 2022
10 Significant Mayo Clinic Center for Individualized Medicine studies of 2021
By Susan Murphy
It has been an impactful year of genomic and multi-omic research and scientific discoveries in Mayo Clinic’s Center for Individualized Medicine. While much focus in 2021 was centered on advancing the knowledge of COVID-19, Mayo scientists and physicians have also worked to develop individualized treatments, prevention measures and diagnostics for patients with rare and undiagnosed diseases, […]
Tags: artificial intelligence, cancer research, Center for Individualized Medicine, genetic testing, genomics, rare disease
December 28, 2021
By Susan Murphy
A new Mayo Clinic study finds 1 in 6 people with pancreatic cancer harbor inherited genetic mutations. Identifying hereditary gene mutations in pancreatic cancer can help determine individualized treatments and potentially prolong survival, according to new Mayo Clinic Center for Individualized Medicine research. In the study, which was published in Clinical and Translational Gastroenterology, nearly 1 in 6 people diagnosed […]
Tags: Center for Individualized Medicine, genetic testing, genomics, Niloy "Jewel" Samadder, pancreatic cancer
December 9, 2021
By Advancing the Science contributor
When John Giudicessi, M.D., Ph.D., was growing up in Des Moines, Iowa, he fueled his incessant curiosity by taking apart unused items in the family’s basement. He caught frogs and turtles in a backyard creek. He loved figuring out how things worked. His parents encouraged him to ask questions. Dr. Giudicessi says the burgeoning scientist […]
Tags: cardiology, Center for Individualized Medicine, Frank Brozovich, John Giudicessi, medical research, Medical Scientist Training Program, Michael Ackerman, molecular pharmacology and experimental therapeutics, precision medicine, Summer Undergraduate Research Fellowship
November 10, 2021
Mayo researchers link gut microbiome to rheumatoid arthritis prognosis
By Susan Murphy
A significant indicator of whether a patient with rheumatoid arthritis will improve over the course of disease may lie in part in their gut, according to new research from Mayo Clinic’s Center for Individualized Medicine. The study, published in Genome Medicine, found that predicting a patient’s future rheumatoid arthritis prognosis could be possible by zeroing in […]
Tags: arthritis, basic science, Center for Individualized Medicine, genomics, gut health, Jaeyun Sung, John Davis III, medical research, microbiome, rheumatology
October 26, 2021
By Susan Murphy
When Michelle Ewy, 38, received an opportunity at Mayo Clinic to get her DNA tested for genetic mutations related to breast and ovarian cancers, and other cancers and diseases, she jumped at the chance. “I wasn’t thinking much of what the outcome would be because there has not been a prevalence of breast or ovarian […]
Tags: BRCA2, breast cancer, cancer research, Center for Individualized Medicine, genetic counseling, genetic testing, genome, hereditary cancer, Konstantinos Lazaridis, Lynch syndrome, ovarian cancer
September 8, 2021
Genetic variants influence migraine treatment response, according to new Mayo study
By Susan Murphy
Migraines affect nearly 40 million people in the U.S. Yet pinpointing an effective prophylactic medication ― the most commonly prescribed drugs for people diagnosed with migraines ― remains a long and complex process. Patients often cycle through medications for weeks or months until achieving a therapeutic response. Now after years of slow progress in migraine therapies […]
Tags: Center for Individualized Medicine, Fred Cutrer, genetics, migraine, neurology, personalized medicine, pharmacogenomics, Richard Weinshilboum
September 2, 2021
Understanding the inner workings of CAR-T therapy
Mayo Clinic researchers have biomanufactured chimeric antigen receptor-T cell therapy (CAR-T cell therapy) in a new way to track the cells’ cancer fighting journey and predict toxic side effects. This Mayo Clinic breakthrough, published in Cancer Immunology Research, also could unravel the mystery of how to unleash CAR-T cell therapy to destroy solid tumors. “This […]
Tags: CAR-T cell therapy, Center for Individualized Medicine, Center for Regenerative Medicine, chimeric antigen receptor therapy, clinical research, clinical trials, hematology, immunotherapy, Kah Whye Peng, Reona Sakemura, Saad Kenderian, Stephen Russell
September 1, 2021
Uterine microbe found to have disease-causing behavior in endometrial cancer
By Susan Murphy
A tiny microbe thriving in the uterine microbiome — a population of bacteria, viruses, yeasts/fungi in and around the uterus— could be a contributing driver of endometrial cancer, according to a new Mayo Clinic study. “We have found that a microbe that is particularly associated with endometrial cancer is capable of pathogenic behavior, and is stimulated […]
Tags: Center for Individualized Medicine, endometrial cancer, Marina Walther-Antonio, microbiome, women's health
August 25, 2021
Mayo Clinic analysis shows how disease, diet, and genomics interact with gut virome
Mayo Clinic researchers published a comprehensive analysis of the gut virome in Gastroenterology, showing how disease, diet and genomics interact with the gut virome in irritable bowel syndrome. This common disorder affects the intestine and manifests as abdominal pain associated with constipation, diarrhea or both. The gut virome is one component of the microbiome (bacteria, fungi, viruses). […]
Tags: Center for Individualized Medicine, DNA, gastroenterology, genomics, gut health, IBS, irritable bowel syndrome, microbiome, Purna Kashyap