Items Tagged ‘metabolomics’
September 27, 2022
Physician-scientist investigates dual CAR-T cell therapy for multiple myeloma cancer
By Susan Murphy 
Leo Sakemura, M.D., Ph.D., a physician-scientist in Mayo Clinic’s Division of Hematology, is working to advance immunotherapy efficacy in multiple myeloma by uncovering treatment resistance mechanisms and developing a more potent immunotherapy approach. His strategy focuses on simultaneously targeting cancer cells and the ecosystem surrounding each tumor, known as the tumor microenvironment. Dr. Sakemura’s previous […]
Tags: cancer genomics, cancer research, CAR-T cell therapy, Center for Individualized Medicine, hematology, immunotherapy, Leo Sakemura, metabolomics, multiple myeloma
July 21, 2021
Mayo researchers develop algorithm to predict rheumatoid arthritis disease activity
By Susan Murphy
Researchers within Mayo Clinic’s Center for Individualized Medicine and Division of Rheumatology have developed a first-of-its-kind machine learning algorithm that can predict rheumatoid arthritis disease activity in a patient. The algorithm analyzes biochemical metabolites ― the product of the body’s metabolism ― in blood. “Having fast, reliable and scalable measures for predicting the clinical course of disease […]
Tags: arthritis, artificial intelligence, autoimmune disorder, biomarkers, Center for Individualized Medicine, clinical research, genomics, Jaeyun Sung, John Davis III, metabolism, metabolomics, rheumatology
January 12, 2021
Physicians have new guidelines for managing rare genetic, metabolic disorders
By Susan Murphy
Physicians now have a blueprint for diagnosing and managing two specific rare inherited metabolic diseases within a group of nearly 150 congenital disorders of glycosylation. These diseases can cause serious and sometimes fatal malfunctions of several organs at or before birth, as well as chronic debilitating symptoms in adults. The consensus guidelines were published in […]
Tags: Center for Individualized Medicine, clinical research, Eva Morava-Kozicz, genetics, genomics, hereditary diseases, metabolomics, rare disease
January 30, 2020
A breakthrough in distinguishing benign adrenal tumors from cancerous ones
By Advancing the Science contributor
By Christoph Bahn Approximately 80 million CT scans are performed in the United States every year. Adrenal tumors are found incidentally in about 5% of these scans. Most of these tumors will turn out to be benign, but a small fraction will be adrenal cortical carcinoma, a type of cancer with high mortality and frequent recurrence; even for […]
Tags: adrenal tumors, biomarkers, biopsy, cancer, clinical research, CT, endocrine cancer, endocrinology, epidemiology, hormones, Irina Bancos, Mayo Clinic Laboratories
October 10, 2018
Mayo lab scientists collaborate to paint a better picture of patient health
On September 24, 2018, the National Institutes of Health (NIH) awarded Mayo Clinic funding to serve as the new Metabolomics Research Core for the Undiagnosed Diseases Network. In this article, we explore the role of metabolomics in medicine at Mayo Clinic, both in research and in patient care. And we celebrate the role that Mayo Clinic […]
Tags: Devin Oglesbee, genetics, genomics, Ian Lanza, Mayo Clinic Laboratories, metabolomics