Items Tagged ‘neurosciences’
July 20, 2021
By Susan Murphy 
Rochester, Minn. — Mayo Clinic researchers have discovered that genetic variants in a neuro-associated gene called SPTBN1 are responsible for causing a neurodevelopmental disorder. The study, published in Nature Genetics, is a first step in finding a potential therapeutic strategy for this disorder, and it increases the number of genes known to be associated with conditions that affect […]
Tags: Center for Individualized Medicine, gene mutation, genetics, genomics, Margot Cousin, neurosciences
February 4, 2021
Dr. Ikezu pushes to find answers for Alzheimer’s disease
By Advancing the Science contributor
Tsuneya Ikezu, M.D., Ph.D., is a Mayo Clinic molecular neuroscientist who originally hails from Japan. Dr. Ikezu’s science career has led him across the globe to work at Mayo Clinic in Florida. His lab will be located temporarily in the Griffin Building. His research focuses on Alzheimer’s disease and related dementia. Dr. Ikezu recently sat […]
Tags: Alzheimer's disease, neurodegenerative disease, neurosciences, Tsuneya Ikezu
January 5, 2021
Looking back on 2020: A successful year of research at Mayo Clinic in Florida
By Advancing the Science contributor
At Mayo Clinic, Research and Education provide the basis for all we are able to do for patients today. Furthermore, they enable practice transformation as we seek to meet future patient needs. From new capabilities in cell therapy and immunotherapy, to advances in neurodegenerative diseases and studies of the virus that causes COVID-19, research at Mayo Clinic continued […]
Tags: Alzheimer's disease, Ben Pollock, biomanufacturing, biomarkers, biostatistics, brain, cancer, CAR-T cell therapy, carbon ion therapy, Center for Regenerative Medicine, chemotherapy, clinical research
November 24, 2020
3D brain models advance Alzheimer’s disease research at Mayo Clinic
A 3D model of brain organoids — “a minibrain in a dish” — mimics human brain structure and provides a new scientific strategy for exploring the pathology of Alzheimer’s disease, Mayo Clinic research discovered. The study, which was published in Nature Communications, finds that the minibrain — an induced pluripotent stem cell-derived cerebral organoid 3D […]
Tags: Alzheimer's disease, Center for Regenerative Medicine, Guojun Bu, medical research, neurosciences
November 10, 2020
Advancing neuroscience at Mayo Clinic in Florida: Dr. Sandro Da Mesquita
By Advancing the Science contributor
What is your background? I am a biochemist by training and performed all of my graduate studies in Portugal, at the School of Medicine of the University of Minho, located in a northern Portuguese city called Braga. It was in grad school that I started to develop a particular taste for neuroscience and cellular and […]
Tags: ALS, Alzheimer's disease, amyotrophic lateral sclerosis, brain, cognitive impairment, dementia, immune system, lymphatic system, neuroimmunology, neurosciences, research education, Sandro Da Mequita
September 17, 2020
Could regenerative medicine hold a key to understanding Alzheimer’s disease?
September is World Alzheimer’s Month, a time to raise awareness of research to unlock scientific mysteries around a disease that robs people of their memory, independence and ultimately their ability to think and reason. Focused on disease causes and cures, the Center for Regenerative Medicine is driving innovation as a collaborative partner in Mayo Clinic’s […]
Tags: Alzheimer's disease, basic science, Center for Regenerative Medicine, dementia, discovery research, Guojun Bu, Melissa Murray, neurology, neurosciences, stem cells
August 6, 2020
Calcium Signaling in Microglia: Implications for Brain Diseases?
By Sara Tiner 
Calcium helps nerves and muscles “fire,” signaling cells to do something like contract a muscle or release a neurotransmitter in the brain. But in one type of brain cell, microglia, this calcium signaling seemed absent. Researchers have long wondered why microglia don’t seem to rely on calcium signaling and now, with a recent publication in […]
Tags: animal model, Anthony Umpierre, basic science, cell signaling, discovery research, Gregory Worrell, Long-Jun Wu, neurology, neurosciences, Yanlu Ying
April 21, 2020
Celebration of student research
By Advancing the Science contributor
Mayo Clinic Graduate School of Biomedical Sciences held its annual Student Research Symposium in September, with poster sessions, oral presentations, a keynote speaker, a Three-Minute Thesis (3MT) competition and Teacher of the Year awards. “The Alumni Association and Mayo Clinic Graduate School of Biomedical Sciences co-sponsored symposium and Teacher of the Year awards are the […]
Tags: biomedical engineering, Center for Clinical and Translational Science, Emma Goddery, general internal medicine, immunology, Lewis Roberts, Martin Fernandez-Zapico, Mayo Clinic Graduate School of Biomedical Sciences, molecular pharmacology and experimental therapeutics, neurosciences, oncology, Stephen Ekker
January 2, 2019
Toward clinical trials for one type of ALS
By Kate Ledger
When a team of Mayo Clinic researchers discovered in 2011 the genetic repeat mutation known as c9orf72, the finding shed new light on amyotrophic lateral sclerosis (ALS). The mutation, which occurs as a short sequence of code repeated hundreds to thousands of times in the gene, is now known to appear in 40 percent of […]
Tags: ALS, amyotrophic lateral sclerosis, Björn Oskarsson, clinical trials, Dennis Dickson, Kevin Boylan, Leonard Petrucelli, Lou Gehrig's disease, neurology, neurosciences, Rosa Rademakers, Tania Gendron
October 30, 2018
Neuroscience powerhouses at Mayo Clinic in Florida
By Advancing the Science contributor
Rosa Rademakers, Ph.D., and Nilufer Ertekin-Taner, M.D., Ph.D., collaborate on Alzheimer’s disease-related research in the Department of Neuroscience at Mayo Clinic in Florida. Dr. Ertekin-Taner’s lab, which focuses on late-onset Alzheimer’s disease, generates large data sets of gene expression and multilevel genomics data that are shared with Dr. Rademakers’ lab, which focuses, in part, on […]
Tags: Alzheimer's disease, medical research, neurosciences, Nilufer Ertekin-Taner, Rosa Rademakers