Advancing the Science

Mayo Clinic Medical Science Blog – an eclectic collection of research- and research education-related stories: feature stories, mini news bites, learning opportunities, profiles and more from Mayo Clinic.

Items Tagged ‘pharmacogenomics’

October 14, 2019

BEAUTY Update: Progress in breast cancer research

By Advancing the Science contributor Advancing the Science contributor

By Barbara J. Toman Chemotherapy is a standard breast cancer treatment, used for aggressive biology breast cancer to shrink tumors in the breast and lymph nodes before surgery, assess response and destroy any undetected cancer cells elsewhere in the patient. But some breast tumors don’t respond well to chemotherapy, putting patients at high risk of […]

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Tags: breast cancer, cancer, Center for Individualized Medicine, chemotherapy, clinical trials, genetics, genomics, individualized medicine, Judy Boughey, Liewei Wang, Matthew Goetz, Mayo Clinic Cancer Center


September 4, 2019

Mayo experts provide insights into how genes affect medication response

By Advancing the Science contributor Advancing the Science contributor

By Sharon Rosen Pharmacogenomics – how a person’s genes affect medication response – is touching virtually every area of medical care.  Findings from the Mayo Clinic RIGHT study (Right Drug, Right Dose, Right Time–Using Genomic Data to Individualize Treatment) showed that 99% of participants had at least one genetic variant that may affect their response […]

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Tags: breast cancer, cancer, cancer genomics, Center for Individualized Medicine, Eric Matey, Lauren Cornell, mental health, Michael Shuh, neurology, opioids, pharmacogenomics, pharmacy


January 22, 2019

Pharmacogenomics: finding the right drug, dose for cancer therapy

By Advancing the Science contributor Advancing the Science contributor

By Sharon Rosen Each year, nearly 300,000 patients receive the lifesaving chemotherapy 5-fluorouracil (5-FU) to treat many types of cancer, including colorectal, breast, bowel, skin, pancreatic, and esophageal cancer. While it can be an effective treatment, it doesn’t work for everyone. In fact, up to 30 percent of those who receive the standard dose can […]

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Tags: cancer, Center for Individualized Medicine, individualized medicine, Mayo Clinic Cancer Center, personalized medicine, pharmacogenomics, Robert Diasio


January 17, 2019

RIGHT 10K: Blazing a trail to health care’s future

By Susan Buckles Susan Buckles

Article by Barbara Toman This article originally appeared on the Center for Individualized Medicine blog Mayo Clinic’s Center for Individualized Medicine (CIM) is nearing the finish line of the first stage of its unique RIGHT 10K study—an effort that doesn’t involve running shoes but nevertheless is paving the way to prescribing medications matched to a […]

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Tags: Center for Individualized Medicine, Eric Matey, genetics, Jessica Wright, pharmacogenomics, RIGHT 10K study


December 10, 2018

Novel data-driven approach for precision medicine

By Colette Gallagher Colette Gallagher

Thousands of patients’ tumors have been sequenced in the past decade, yielding a rich source of data on the changes associated with the cancer development and treatment response. However, there are no validated methods that are used in the clinic to select the best therapy. Today, Mayo Clinic researchers report an omics-guided (comprehensive) drug prioritization […]

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Tags: cancer, Center for Individualized Medicine, Judy Boughey, Krishna Rani Kalari, Liewei Wang, Matthew Goetz, personalized medicine, pharmacogenomics


November 6, 2018

Mayo Clinic research combines genetics and psychiatry to seek biomarkers for precise alcohol abuse therapies

By Susan Buckles Susan Buckles

This article originally appeared on the Center for Individualized Medicine blog on Oct. 23, 2018. Mayo Clinic research is bringing together knowledge of psychiatry, genetics, metabolomics, pharmacogenomics and artificial intelligence to seek biological markers associated with alcohol use disorder and treatment response. Finding the molecular drivers of alcohol use disorder commonly known as alcoholism, could […]

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Tags: Center for Individualized Medicine, Mark Frye, pharmacogenomics, Richard Weinshilboum


October 24, 2018

Bringing pharmacogenomics to your medical practice

By Susan Buckles Susan Buckles

After decades of research, pharmacogenomics is “ready for prime time” so to speak. Mayo clinic is a leader in moving pharmacogenomics into clinical care — with the goal of helping providers identify medications that are compatible with their patients’ genetic profiles. Drugs and Genes: Pharmacogenomics for the Modern Health Care Team 2018 is an opportunity […]

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Tags: cardiology, Center for Individualized Medicine, Fadi Shamoun, pharmacogenomics


August 14, 2018

Research suggests genetics are key in treating night sweats

By Advancing the Science contributor Advancing the Science contributor

This post originally was published on the Center for Individualized Medicine blog on June 25, 2018 Article by Heather Carlson Women going through menopause know all too well the discomfort associated with night sweats. Hormone therapy is often used to prevent night sweats. But finding the right dose of estrogen can be tricky, with some […]

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Tags: Ann Moyer, Center for Individualized Medicine, genomics, menopause, pharmacogenomics, Richard Weinshilboum, Virginia Miller, women's health


May 24, 2018

Mayo’s RIGHT 10K – moving pharmacogenomics into everyday clinical practice

By Susan Buckles Susan Buckles

This article originally appeared on the Center for Individualized Medicine blog on March 20, 2018. By Sharon Rosen After nearly half a century of research, Mayo Clinic is a leader in moving pharmacogenomics into clinical practice. This year pharmacogenomics test results for 10,000 Mayo Clinic patients, all participants in the RIGHT 10K study, are being added […]

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Tags: biobank, Center for Individualized Medicine, DNA testing, genetics, Paul Takahashi, pharmacogenomics, Richard Weinshilboum


April 23, 2018

Registration opens for Individualizing Medicine 2018 Conference

By Susan Buckles Susan Buckles

This post originally appeared on the Individualized Medicine blog on April 3, 2018. By Sharon Rosen Gene editing, artificial intelligence, pharmacogenomics and a new era of genomic testing to identify and hopefully treat inherited cancer are just a few of the emerging areas of precision medicine that have the potential to transform patient care. These […]

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Tags: Center for Individualized Medicine, genomics, individualized medicine, Individualizing Medicine Conference, microbiome, pharmacogenomics, precision medicine, Timothy Curry


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