Advancing the Science

Mayo Clinic Medical Science Blog – an eclectic collection of research- and research education-related stories: feature stories, mini news bites, learning opportunities, profiles and more from Mayo Clinic.

Items Tagged ‘pharmacogenomics’

January 22, 2019

Pharmacogenomics: finding the right drug, dose for cancer therapy

By Advancing the Science contributor advancingthescience

By Sharon Rosen Each year, nearly 300,000 patients receive the lifesaving chemotherapy 5-fluorouracil (5-FU) to treat many types of cancer, including colorectal, breast, bowel, skin, pancreatic, and esophageal cancer. While it can be an effective treatment, it doesn’t work for everyone. In fact, up to 30 percent of those who receive the standard dose can […]

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Tags: cancer, Center for Individualized Medicine, individualized medicine, Mayo Clinic Cancer Center, personalized medicine, pharmacogenomics, Robert Diasio


January 17, 2019

RIGHT 10K: Blazing a trail to health care’s future

By Susan Buckles susanbuckles

Article by Barbara Toman This article originally appeared on the Center for Individualized Medicine blog Mayo Clinic’s Center for Individualized Medicine (CIM) is nearing the finish line of the first stage of its unique RIGHT 10K study—an effort that doesn’t involve running shoes but nevertheless is paving the way to prescribing medications matched to a […]

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Tags: Center for Individualized Medicine, Eric Matey, genetics, Jessica Wright, pharmacogenomics, RIGHT 10K study


December 10, 2018

Novel data-driven approach for precision medicine

By Colette Gallagher colettegallagher

Thousands of patients’ tumors have been sequenced in the past decade, yielding a rich source of data on the changes associated with the cancer development and treatment response. However, there are no validated methods that are used in the clinic to select the best therapy. Today, Mayo Clinic researchers report an omics-guided (comprehensive) drug prioritization […]

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Tags: cancer, Center for Individualized Medicine, Judy Boughey, Krishna Rani Kalari, Liewei Wang, Matthew Goetz, PANOPLY, personalized medicine, pharmacogenomics


November 6, 2018

Mayo Clinic research combines genetics and psychiatry to seek biomarkers for precise alcohol abuse therapies

By Susan Buckles susanbuckles

This article originally appeared on the Center for Individualized Medicine blog on Oct. 23, 2018. Mayo Clinic research is bringing together knowledge of psychiatry, genetics, metabolomics, pharmacogenomics and artificial intelligence to seek biological markers associated with alcohol use disorder and treatment response. Finding the molecular drivers of alcohol use disorder commonly known as alcoholism, could […]

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Tags: Center for Individualized Medicine, Mark Frye, pharmacogenomics, Richard Weinshilboum


October 24, 2018

Bringing pharmacogenomics to your medical practice

By Susan Buckles susanbuckles

After decades of research, pharmacogenomics is “ready for prime time” so to speak. Mayo clinic is a leader in moving pharmacogenomics into clinical care — with the goal of helping providers identify medications that are compatible with their patients’ genetic profiles. Drugs and Genes: Pharmacogenomics for the Modern Health Care Team 2018 is an opportunity […]

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Tags: cardiology, Center for Individualized Medicine, Fadi Shamoun, pharmacogenomics


August 14, 2018

Research suggests genetics are key in treating night sweats

By Advancing the Science contributor advancingthescience

This post originally was published on the Center for Individualized Medicine blog on June 25, 2018 Article by Heather Carlson Women going through menopause know all too well the discomfort associated with night sweats. Hormone therapy is often used to prevent night sweats. But finding the right dose of estrogen can be tricky, with some […]

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Tags: Ann Moyer, Center for Individualized Medicine, genomics, menopause, pharmacogenomics, Richard Weinshilboum, Virginia Miller, women's health


May 24, 2018

Mayo’s RIGHT 10K – moving pharmacogenomics into everyday clinical practice

By Susan Buckles susanbuckles

This article originally appeared on the Center for Individualized Medicine blog on March 20, 2018. By Sharon Rosen After nearly half a century of research, Mayo Clinic is a leader in moving pharmacogenomics into clinical practice. This year pharmacogenomics test results for 10,000 Mayo Clinic patients, all participants in the RIGHT 10K study, are being added […]

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Tags: biobank, Center for Individualized Medicine, DNA testing, genetics, Paul Takahashi, pharmacogenomics, Richard Weinshilboum


April 23, 2018

Registration opens for Individualizing Medicine 2018 Conference

By Susan Buckles susanbuckles

This post originally appeared on the Individualized Medicine blog on April 3, 2018. By Sharon Rosen Gene editing, artificial intelligence, pharmacogenomics and a new era of genomic testing to identify and hopefully treat inherited cancer are just a few of the emerging areas of precision medicine that have the potential to transform patient care. These […]

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Tags: Center for Individualized Medicine, genomics, individualized medicine, Individualizing Medicine Conference, microbiome, pharmacogenomics, precision medicine, Timothy Curry


April 10, 2018

New international practice guidelines for using tamoxifen to treat breast cancer

By Colette Gallagher colettegallagher

An international group of clinicians and scientists representing the Clinical Pharmacogenetics Implementation Consortium (CPIC) published the first-ever clinical practice guideline for using CYP2D6 genotype to guide tamoxifen therapy in Clinical Pharmacology and Therapeutics. Tamoxifen is a hormonal agent used for the prevention and treatment of premenopausal and postmenopausal breast cancer that is estrogen receptor positive. CYP2D6 […]

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Tags: breast cancer, Center for Individualized Medicine, genetic testing, Matthew Goetz, Mayo Clinic Cancer Center, pharmacogenomics, precision medicine


March 15, 2018

Pharmacogenomics testing helps children with acid reflux disease find relief

By Susan Buckles susanbuckles

Article by Sharon Rosen This article originally appeared on the Center for Individualized Medicine blog. Many people have occasional acid reflux or heartburn after eating a heavy or spicy meal. But for children and adults with acid reflux disease, also known as gastroesophageal reflux disease (GERD), the symptoms are more frequent and severe. These patients […]

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Tags: Center for Individualized Medicine, genetic testing, Imad Absah, pediatric gastroenterology, pharmacogenomics


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