August 2, 2022
Addressing the challenges of chimeric antigen receptor-T cell therapy
By Advancing the Science contributor
Article by Marla Broadfoot Chimeric antigen receptor-T cell therapy (CAR-T cell therapy) — a type of immunotherapy that reprograms a patient’s T cells to recognize and destroy cancer cells — has revolutionized the treatment of blood cancers. While the technique has successfully sent patients with advanced disease into remission, it is far from perfect. CAR-T […]
Tags: cancer therapy, CAR-T cell therapy, Center for Regenerative Medicine, Hong Qin, regenerative immunotherapy, Saad Kenderian
December 27, 2021
A year of new directions and advancements for regenerative medicine
2021 has been a year of significant innovation across the field of regenerative medicine at Mayo Clinic. Important advancements in preclinical research, as well as new regenerative treatments for patients, further are solidifying Mayo Clinic’s reputation as a world-class leader in regenerative medicine. Regenerative medicine is still a relatively new field of practice, representing a […]
Tags: biomanufacturing, Center for Regenerative Medicine, Janani Reisenauer, Julie Allickson, regenerative medicine, Saad Kenderian
September 2, 2021
Understanding the inner workings of CAR-T therapy
Mayo Clinic researchers have biomanufactured chimeric antigen receptor-T cell therapy (CAR-T cell therapy) in a new way to track the cells’ cancer fighting journey and predict toxic side effects. This Mayo Clinic breakthrough, published in Cancer Immunology Research, also could unravel the mystery of how to unleash CAR-T cell therapy to destroy solid tumors. “This […]
Tags: CAR-T cell therapy, Center for Individualized Medicine, Center for Regenerative Medicine, chimeric antigen receptor therapy, clinical research, clinical trials, hematology, immunotherapy, Kah Whye Peng, Reona Sakemura, Saad Kenderian, Stephen Russell
February 1, 2021
Mayo Clinic Research in the news — 2/1/2021
Mayo Clinic faculty continue to share their expertise across a broad range of medical and health care topics, including women’s health, concussion, disparities in care, and the never abating COVID-19. Mayo Clinic Indicates Age Has Distinct Influences on Sex-Related Outcomes After Heart Attack Pharmacy Times, 1/27/2021 Researchers at the Mayo Clinic have found ways that […]
Tags: Alex Adjei, Ali Duarte Garcia, breast cancer, CAR-T cell therapy, Centers for Disease Control and Prevention, concussion, COVID-19, depression, diabetes, drug discovery, gene mutation, Grzegorz Nowakowski
August 18, 2020
Spotlighting 2020 graduates of Mayo Clinic College of Medicine and Science
Integrating new discoveries into patient care requires a workforce equipped to deliver the latest innovations. That’s why training the workforce of the future is a key objective of Mayo Clinic Education. Every year, Mayo Clinic’s College of Medicine and Science advances new graduates to their next levels of research and/or medical practice to address the […]
Tags: Andre Terzic, Atta Behfar, CAR-T cell therapy, Center for Regenerative Medicine, Karen Hedin, Mayo Clinic Alix School of Medicine, Mayo Clinic College of Medicine and Science, Mayo Clinic Graduate School of Biomedical Sciences, Medical Scientist Training Program, Rosalie Sterner, Saad Kenderian, Sinibaldo Romero Arocha
February 18, 2019
Head to the Lab for the Treatments of Tomorrow
By Sara Tiner
Medical breakthroughs start in the lab with a phase of research called discovery science. It helps to understand how the body functions and how disease begins at the most basic level. That in turn provides insight into how whatever has gone wrong can be fixed. To kick off the medical treatments of tomorrow, the Center […]
Tags: Aleksey Matveyenko, basic science, CAR-T cell therapy, Center for Biomedical Discovery, Christina Pabelick, colon cancer, diabetes, discovery research, Hu Li, Hu Zeng, lupus, Paul Galardy
February 4, 2019
“Only” a medical student, already advancing the science
By Jon Holten
Rosalie Sterner is already impressive, concurrently pursuing her M.D. and Ph.D. degrees through Mayo Clinic College of Medicine and Science. However, recently she made additional waves, as the lone medical student to receive the 2018 Outstanding Abstract Achievement Award from the American Society of Hematology. Sterner received this award and presented her work on development […]
Tags: CAR-T cell therapy, clinical trials, hematology, immunology, Karen Hedin, lymphoma, Rosalie Sterner, Saad Kenderian
January 10, 2019
Gene therapy: potential and pitfalls
Research is advancing gene therapy as a possible treatment or eventual cure for genetic diseases that bedevil modern science. Gene therapy was conceived over 20 years ago, and until recently, remained largely in the research lab. But gene therapy products are now beginning to be approved by the U.S. Food and Drug Administration for clinical […]
Tags: Center for Individualized Medicine, David Deyle, gene mutation, gene therapy, Saad Kenderian
August 23, 2018
Using the body to recognize and attack cancer
This article originally appeared in the Center for Individualized Medicine blog on July 23, 2018 For as long as he can remember, Saad Kenderian, M.B., Ch.B., wanted to be a physician. Nothing could blunt his resolve –not even when improvised explosive devices, bombs and trappings of war put the medical school in his native Baghdad, […]
Tags: cancer, CAR-T cell therapy, Center for Individualized Medicine, gene therapy, immunotherapy, Mayo Clinic Cancer Center, Saad Kenderian